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• W4200057710 abstract "ABSTRACT The mechanism of rotatory catalysis in ATP-hydrolyzing molecular motors remain an unresolved puzzle in biological energy transfer. Notwith standing the wealth of available biochemical and structural information inferred from years of experiments, knowledge on how the coupling between the chemical and mechanical steps within motors enforces directional rotatory movements remains fragmentary. Even more contentious is to pinpoint the rate-limiting step of a multi-step rotation process. Here, using Vacuolar or V 1 -type hexameric ATPase as an exemplary rotational motor, we present a model of the complete 4-step conformational cycle involved in rotatory catalysis. First, using X-ray crystallography a new intermediate or ‘dwell’ is identified, which enables the release of an inorganic phosphate (or P i ) after ATP hydrolysis. Using molecular dynamics simulations, this new dwell is placed in a sequence with three other crystal structures to derive a putative cyclic rotation path. Free-energy simulations are employed to estimate the rate of the hexameric protein transformations, and delineate allosteric effects that allow new reactant ATP entry only after hydrolysis product exit. An analysis of transfer entropy brings to light how the sidechain-level interactions transcend into larger-scale reorganizations, highlighting the role of the ubiquitous arginine-finger residues in coupling chemical and mechanical information. Inspection of all known rates encompassing the 4-step rotation mechanism implicates overcoming of the ADP interactions with V 1 -ATPase to be the rate-limiting step of motor action." @default.
• W4200057710 created "2021-12-31" @default.
• W4200057710 creator A5016176700 @default.
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• W4200057710 date "2021-12-09" @default.
• W4200057710 modified "2023-09-27" @default.
• W4200057710 title "Revealing a hidden intermediate of rotatory catalysis with X-ray crystallography and Molecular simulations" @default.
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• W4200057710 doi "https://doi.org/10.1101/2021.12.07.471682" @default.
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