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- W4200069709 endingPage "146" @default.
- W4200069709 startingPage "123" @default.
- W4200069709 abstract "Discovered over four decades ago, transforming growth factor β (TGFβ) is a potent pleiotropic cytokine that has context-dependent effects on most cell types. It acts as a tumor suppressor in some cancers and/or supports tumor progression and metastasis through its effects on the tumor stroma and immune microenvironment. In TGFβ-responsive tumors it can promote invasion and metastasis through epithelial-mesenchymal transformation, the appearance of cancer stem cell features, and resistance to many drug classes, including checkpoint blockade immunotherapies. Here we consider the biological activities of TGFβ action on different cells of relevance toward improving immunotherapy outcomes for patients, with a focus on the adaptive immune system. We discuss recent advances in the development of drugs that target the TGFβ signaling pathway in a tumor-specific or cell type–specific manner to improve the therapeutic window between response rates and adverse effects." @default.
- W4200069709 created "2021-12-31" @default.
- W4200069709 creator A5001187903 @default.
- W4200069709 creator A5072166823 @default.
- W4200069709 creator A5073440429 @default.
- W4200069709 date "2022-04-11" @default.
- W4200069709 modified "2023-10-17" @default.
- W4200069709 title "TGFβ: Signaling Blockade for Cancer Immunotherapy" @default.
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