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• W4200073955 abstract "Background: The role of purinergic P2X7 receptor (P2X7R) is of interest due to its involvement in inflammation and mediating immune cell responses. P2X7R is particularly implicated in the development of inflammatory bowel disease (IBD). However, the extent of the actions of P2X7R in the gastrointestinal (GI) system under physiological and pathophysiological conditions remains to be elucidated. This systematic review aimed to identify, summarize and evaluate the evidence for a critical role of P2X7R in the GI system. Methods: We searched PubMed, Embase and Scopus with search terms pertained to P2X7R in the GI system in disease or physiological state, including P2X7 or P2X7 receptor or purinergic signaling in combination with any of the terms intestine or colon or gut or gastrointestinal, pathology or inflammation or disease or disorder, and physiology or expression. Titles and abstracts were screened for potentially eligible full texts, and animal and human studies published in English were included in this study. Data were extracted from papers meeting inclusion criteria. Meta-analysis was not feasible given the study diversity. Results: There were 48 papers included in this review. We identified 14 experimental colitis models, three sepsis models and one ischemia-reperfusion injury model. Among them, 11 studies examined P2X7R in GI infections, six studies on immune cell regulation, four studies on GI inflammation, two studies on GI malignancies, three studies involving intestinal injury due to various causes, two studies on ATP-activated P2X7R in the GI system and two studies on metabolic regulation. Conclusion: Evidence supports P2X7R mediating inflammation and immune cell responses in GI inflammation, infections and injury due to IBD and other challenges to the intestinal wall. P2X7R inhibition by gene knockout or by application of P2X7R antagonists can reduce tissue damage by suppressing inflammation. P2X7R is also implicated in GI malignancies and glucose and lipid homeostasis. P2X7R blockade, however, did not always lead to beneficial outcomes in the various pathological models of study." @default.
• W4200073955 created "2021-12-31" @default.
• W4200073955 creator A5049264813 @default.
• W4200073955 creator A5062392359 @default.
• W4200073955 creator A5066716873 @default.
• W4200073955 date "2021-12-20" @default.
• W4200073955 modified "2023-10-15" @default.
• W4200073955 title "Understanding the Role of Purinergic P2X7 Receptors in the Gastrointestinal System: A Systematic Review" @default.
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• W4200073955 cites W1559956046 @default.
• W4200073955 cites W1640099532 @default.
• W4200073955 cites W1922702151 @default.
• W4200073955 cites W1969485182 @default.
• W4200073955 cites W1996252358 @default.
• W4200073955 cites W1998827702 @default.
• W4200073955 cites W2014379411 @default.
• W4200073955 cites W2021323827 @default.
• W4200073955 cites W2022548397 @default.
• W4200073955 cites W2023945291 @default.
• W4200073955 cites W2025904016 @default.
• W4200073955 cites W2036572641 @default.
• W4200073955 cites W2036949982 @default.
• W4200073955 cites W2043647235 @default.
• W4200073955 cites W2045576152 @default.
• W4200073955 cites W2052616377 @default.
• W4200073955 cites W2055692928 @default.
• W4200073955 cites W2075897532 @default.
• W4200073955 cites W2081177829 @default.
• W4200073955 cites W2085167407 @default.
• W4200073955 cites W2089597910 @default.
• W4200073955 cites W2099376515 @default.
• W4200073955 cites W2118063004 @default.
• W4200073955 cites W2120390711 @default.
• W4200073955 cites W2140489687 @default.
• W4200073955 cites W2141778013 @default.
• W4200073955 cites W2148085458 @default.
• W4200073955 cites W2149371927 @default.
• W4200073955 cites W2156346381 @default.
• W4200073955 cites W2168269445 @default.
• W4200073955 cites W2170170900 @default.
• W4200073955 cites W2222487181 @default.
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• W4200073955 cites W2474206346 @default.
• W4200073955 cites W2507352079 @default.
• W4200073955 cites W2566682428 @default.
• W4200073955 cites W2592313443 @default.
• W4200073955 cites W2594070031 @default.
• W4200073955 cites W2595845301 @default.
• W4200073955 cites W2615856274 @default.
• W4200073955 cites W2617311130 @default.
• W4200073955 cites W2705132003 @default.
• W4200073955 cites W2730462092 @default.
• W4200073955 cites W2732436497 @default.
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• W4200073955 cites W2765489847 @default.
• W4200073955 cites W2781647206 @default.
• W4200073955 cites W2790502136 @default.
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• W4200073955 cites W2912336439 @default.
• W4200073955 cites W2913377662 @default.
• W4200073955 cites W2939562813 @default.
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• W4200073955 cites W2954535162 @default.
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• W4200073955 cites W3136804309 @default.
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• W4200073955 doi "https://doi.org/10.3389/fphar.2021.786579" @default.
• W4200073955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34987401" @default.
• W4200073955 hasPublicationYear "2021" @default.
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