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- W4200074319 endingPage "50" @default.
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- W4200074319 abstract "Chronic hepatitis C virus (HCV) infection is associated with naïve CD4+ T cell lymphopenia and long-standing/persistent elevation of cellular and soluble immune activation parameters, the latter heightened in the setting of HIV co-infection. The underlying mechanisms are not completely understood. However, we recently reported that accelerated peripheral cell death may contribute to naïve CD4+ T cell loss and that mechanistic relationships between monocyte activation, T cell activation, and soluble inflammatory mediators may also contribute. Chronic HCV infection can be cured by direct-acting anti-viral (DAA) therapy, and success is defined as sustained virological response (SVR, undetectable HCV RNA (ribonucleic acid) at 12 weeks after DAA treatment completion). However, there is no general consensus on the short-term and long-term immunological outcomes of DAA therapy. Here, we consolidate previous reports on the partial normalization of naïve CD4+ lymphopenia and T cell immune activation and the apparent irreversibility of monocyte activation following DAA therapy in HCV infected and HCV/HIV co-infected individuals. Further, advanced age and cirrhosis are associated with delayed or abrogation of immune reconstitution after DAA therapy, an indication that non-viral factors also likely contribute to host immune dysregulation in HCV infection." @default.
- W4200074319 created "2021-12-31" @default.
- W4200074319 creator A5004051430 @default.
- W4200074319 creator A5023763279 @default.
- W4200074319 creator A5028704012 @default.
- W4200074319 creator A5072468112 @default.
- W4200074319 date "2021-12-29" @default.
- W4200074319 modified "2023-10-18" @default.
- W4200074319 title "Variable Normalization of Naïve CD4+ Lymphopenia and Markers of Monocyte and T Cell Activation over the Course of Direct-Acting Anti-Viral Treatment of Chronic Hepatitis C Virus Infection" @default.
- W4200074319 cites W1482873758 @default.
- W4200074319 cites W1580217007 @default.
- W4200074319 cites W162603234 @default.
- W4200074319 cites W1652988747 @default.
- W4200074319 cites W1881390415 @default.
- W4200074319 cites W1934824553 @default.
- W4200074319 cites W1968134248 @default.
- W4200074319 cites W1970925500 @default.
- W4200074319 cites W1971783790 @default.
- W4200074319 cites W1974312247 @default.
- W4200074319 cites W1975032088 @default.
- W4200074319 cites W1975222853 @default.
- W4200074319 cites W1975712964 @default.
- W4200074319 cites W1976779944 @default.
- W4200074319 cites W1988446661 @default.
- W4200074319 cites W2003107797 @default.
- W4200074319 cites W2007157548 @default.
- W4200074319 cites W2009519656 @default.
- W4200074319 cites W2013134494 @default.
- W4200074319 cites W2015433805 @default.
- W4200074319 cites W2016162846 @default.
- W4200074319 cites W2016729225 @default.
- W4200074319 cites W2037555606 @default.
- W4200074319 cites W2039674728 @default.
- W4200074319 cites W2040750039 @default.
- W4200074319 cites W2043344627 @default.
- W4200074319 cites W2056157521 @default.
- W4200074319 cites W2059239713 @default.
- W4200074319 cites W2059382917 @default.
- W4200074319 cites W2063414191 @default.
- W4200074319 cites W2070299455 @default.
- W4200074319 cites W2077918337 @default.
- W4200074319 cites W2082402714 @default.
- W4200074319 cites W2084038115 @default.
- W4200074319 cites W2091600198 @default.
- W4200074319 cites W2091687755 @default.
- W4200074319 cites W2092490027 @default.
- W4200074319 cites W2100990844 @default.
- W4200074319 cites W2102145741 @default.
- W4200074319 cites W2102330096 @default.
- W4200074319 cites W2104010560 @default.
- W4200074319 cites W2105203257 @default.
- W4200074319 cites W2106036005 @default.
- W4200074319 cites W2108599860 @default.
- W4200074319 cites W2131109099 @default.
- W4200074319 cites W2166625995 @default.
- W4200074319 cites W2266553947 @default.
- W4200074319 cites W2277396963 @default.
- W4200074319 cites W2300402771 @default.
- W4200074319 cites W2315484453 @default.
- W4200074319 cites W2334018897 @default.
- W4200074319 cites W2344290362 @default.
- W4200074319 cites W2412188052 @default.
- W4200074319 cites W2424017304 @default.
- W4200074319 cites W2512153951 @default.
- W4200074319 cites W2668148880 @default.
- W4200074319 cites W2769174008 @default.
- W4200074319 cites W2771738980 @default.
- W4200074319 cites W2775503072 @default.
- W4200074319 cites W2811349264 @default.
- W4200074319 cites W2891199039 @default.
- W4200074319 cites W2900195724 @default.
- W4200074319 cites W2903384096 @default.
- W4200074319 cites W2911416346 @default.
- W4200074319 cites W2972212509 @default.
- W4200074319 cites W3013365335 @default.
- W4200074319 cites W3015315374 @default.
- W4200074319 cites W3023016118 @default.
- W4200074319 cites W3025822722 @default.
- W4200074319 cites W3128215963 @default.
- W4200074319 cites W3129503124 @default.
- W4200074319 cites W3150218751 @default.
- W4200074319 cites W3156316183 @default.
- W4200074319 cites W3189438345 @default.
- W4200074319 cites W3196330791 @default.
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- W4200074319 doi "https://doi.org/10.3390/v14010050" @default.
- W4200074319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35062255" @default.
- W4200074319 hasPublicationYear "2021" @default.
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