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- W4200081993 abstract "We previously demonstrated that the non-calcemic pregnacalciferol (pD) analog 17,20S (OH)2pD suppressed TGF-β1-induced type I collagen production in cultured normal human dermal fibroblasts. In the present studies, we examined fibroblasts cultured from the lesional skin of patients with systemic sclerosis (scleroderma (SSc)) and assessed the effects of 17,20S(OH)2pD on fibrosis-related mediators. Dermal fibroblast lines were established from skin biopsies from patients with SSc and healthy controls. Fibroblasts were cultured with either 17,20S(OH)2pD or 1,25(OH)2D3 (positive control) with/without TGF-β1 stimulation and extracted for protein and/or mRNA for collagen synthesis and mediators of fibrosis (MMP-1, TIMP-1, PAI-1, BMP-7, PGES, GLI1, and GLI2). 1 7,20S(OH)2pD (similar to 1,25(OH)2D3) significantly suppressed net total collagen production in TGF-β1-stimulated normal donor fibroblast cultures and in cultures of SSc dermal fibroblasts. 17,20S(OH)2pD (similar to 1,25(OH)2D3) also increased MMP-1, BMP-7, and PGES and decreased TIMP-1 and PAI1 expression in SSc fibroblasts. Although 17,20S(OH)2pD had no effect on Gli1 or Gli2 in SSc fibroblasts, it increased Gli2 expression when cultured with TGF-β1 in normal fibroblasts. These studies demonstrated that 17,20S(OH)2pD modulates mediators of fibrosis to favor the reduction of fibrosis and may offer new noncalcemic secosteroidal therapeutic approaches for treating SSc and fibrosis." @default.
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- W4200081993 date "2021-12-29" @default.
- W4200081993 modified "2023-09-26" @default.
- W4200081993 title "Modulation by 17,20S(OH)2pD of Fibrosis-Related Mediators in Dermal Fibroblast Lines from Healthy Donors and from Patients with Systemic Sclerosis" @default.
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- W4200081993 cites W1972743589 @default.
- W4200081993 cites W1974879451 @default.
- W4200081993 cites W1978537670 @default.
- W4200081993 cites W1978837598 @default.
- W4200081993 cites W1985583116 @default.
- W4200081993 cites W1986400854 @default.
- W4200081993 cites W1987860480 @default.
- W4200081993 cites W1993155768 @default.
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- W4200081993 cites W1995721099 @default.
- W4200081993 cites W1996480023 @default.
- W4200081993 cites W2009462327 @default.
- W4200081993 cites W2013530991 @default.
- W4200081993 cites W2027278752 @default.
- W4200081993 cites W2031746740 @default.
- W4200081993 cites W2038379915 @default.
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- W4200081993 cites W2060463997 @default.
- W4200081993 cites W2061423598 @default.
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- W4200081993 doi "https://doi.org/10.3390/ijms23010367" @default.
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