Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200086619> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4200086619 endingPage "305" @default.
- W4200086619 startingPage "305" @default.
- W4200086619 abstract "Abstract To explore racial disparities in the interaction between Hashimoto thyroiditis (HT), Graves disease (GD), and Alzheimer’s disease (AD)we used age-adjusted rates for Medicare beneficiaries aged 65+. We investigated race/ethnicity/gender-specific trends of age-adjusted prevalence of HT and GD over 1991-2017 and used the Cox proportional hazards model with propensity score matching to explore the associations between AD and these thyroid disorders. The total age-adjusted prevalence of GD was increasing over the study period reaching a maximum of 0.35% in 2014 followed by a gradual decline. Except for relatively high prevalence rates in Native American Males, no statistically significant sex/race-related differences were identified. GD was found to be associated with an increased risk of AD onset [HR: 1.129; CI: 1.050-1.215]. The mechanism of interaction between thyroiditis and AD could follow several alternative pathways. The primary mechanism involves changes in blood vessel function, mostly arterial wall stiffness, which leads to increased pulse wave velocity and consequently to the higher amplitude of oscillation of the peripheral microcapillary system in the brain leading to cerebral leukoaraiosis and damage in kidney tissue. This, in turn, leads to kidney diseases (themselves associated with AD/ADRD), increased for HT and decreased for GD LDL cholesterol levels and an increased for HT and decreased for GD total/HDL cholesterol ratio, which has an important role in increased common carotid intima-media thickness (CIMT) in hypothyroid patients and is linked to arteriosclerosis. Additionally, both, endothelial dysfunction and arterial stiffness are risk factors for coronary or artery disease and consequently increase risks for AD/ADRD." @default.
- W4200086619 created "2021-12-31" @default.
- W4200086619 creator A5049441585 @default.
- W4200086619 creator A5053766862 @default.
- W4200086619 creator A5072036865 @default.
- W4200086619 date "2021-12-01" @default.
- W4200086619 modified "2023-10-18" @default.
- W4200086619 title "Links of Autoimmune Thyroid Disorders to Alzheimer’s Disease for Medicare Beneficiaries Ages 65+" @default.
- W4200086619 doi "https://doi.org/10.1093/geroni/igab046.1181" @default.
- W4200086619 hasPublicationYear "2021" @default.
- W4200086619 type Work @default.
- W4200086619 citedByCount "0" @default.
- W4200086619 crossrefType "journal-article" @default.
- W4200086619 hasAuthorship W4200086619A5049441585 @default.
- W4200086619 hasAuthorship W4200086619A5053766862 @default.
- W4200086619 hasAuthorship W4200086619A5072036865 @default.
- W4200086619 hasBestOaLocation W42000866191 @default.
- W4200086619 hasConcept C126322002 @default.
- W4200086619 hasConcept C134018914 @default.
- W4200086619 hasConcept C159641895 @default.
- W4200086619 hasConcept C164705383 @default.
- W4200086619 hasConcept C2775850156 @default.
- W4200086619 hasConcept C2778319312 @default.
- W4200086619 hasConcept C2778696486 @default.
- W4200086619 hasConcept C2779134260 @default.
- W4200086619 hasConcept C526584372 @default.
- W4200086619 hasConcept C71924100 @default.
- W4200086619 hasConcept C84393581 @default.
- W4200086619 hasConceptScore W4200086619C126322002 @default.
- W4200086619 hasConceptScore W4200086619C134018914 @default.
- W4200086619 hasConceptScore W4200086619C159641895 @default.
- W4200086619 hasConceptScore W4200086619C164705383 @default.
- W4200086619 hasConceptScore W4200086619C2775850156 @default.
- W4200086619 hasConceptScore W4200086619C2778319312 @default.
- W4200086619 hasConceptScore W4200086619C2778696486 @default.
- W4200086619 hasConceptScore W4200086619C2779134260 @default.
- W4200086619 hasConceptScore W4200086619C526584372 @default.
- W4200086619 hasConceptScore W4200086619C71924100 @default.
- W4200086619 hasConceptScore W4200086619C84393581 @default.
- W4200086619 hasIssue "Supplement_1" @default.
- W4200086619 hasLocation W42000866191 @default.
- W4200086619 hasLocation W42000866192 @default.
- W4200086619 hasOpenAccess W4200086619 @default.
- W4200086619 hasPrimaryLocation W42000866191 @default.
- W4200086619 hasRelatedWork W1981968121 @default.
- W4200086619 hasRelatedWork W2011960454 @default.
- W4200086619 hasRelatedWork W2021841321 @default.
- W4200086619 hasRelatedWork W2060603500 @default.
- W4200086619 hasRelatedWork W2070295037 @default.
- W4200086619 hasRelatedWork W2088569338 @default.
- W4200086619 hasRelatedWork W2155312245 @default.
- W4200086619 hasRelatedWork W2163236351 @default.
- W4200086619 hasRelatedWork W2411536504 @default.
- W4200086619 hasRelatedWork W2748952813 @default.
- W4200086619 hasVolume "5" @default.
- W4200086619 isParatext "false" @default.
- W4200086619 isRetracted "false" @default.
- W4200086619 workType "article" @default.