Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200089999> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4200089999 abstract "Abstract Background: Corticosteroid resistance pulmonary fibrosis is a major health problem. This study aimed to determine the effectiveness of nintedanib on corticosteroid resistance pulmonary fibrosis induced by bleomycin in mice. Methods: The mice were divided into five groups 12 mice each. control group, BLM group received single dose of bleomycin (BLM), BLM+MP group received BLM and methylprednisolone (MP), BLM+NIN group received BLM and nintedanib(NIN) and BLM + NIN + MP group. The lung tissues were obtained for biochemical analysis, gene expression and histopathological examination on day 7 and day 28. Results: after 7 days, both NIN groups showed a significant decrease in the levels of interleukin-2, interleukin-4, interferon-gamma, lung tumor necrosis factor-alpha, Malondialdehyde and lung water content with a significant increase in the Glutathione level in lung tissues compared to MP group. After 28 days, both NIN groups showed a significant reduction in hydroxyproline, and Trans-forming Growth Factor beta lung tissues contents compared to MP group, and they showed a positive effect on the expression of β 3 &β6 integrins compared to the negative effect of MP group. Histopathologically, both NIN groups showed significant improvement compared to MP group by H&E and Masson’s trichrome stains. Immunohistochemical staining revealed negative BCL-2 expression in the cytoplasm of bronchiolar epithelium in both NIN groups after 7 and 28 days of treatment. Lung tissue morphometric studies showed significant improvement of pathological changes induced by BLM in both NIN groups. Conclusion: Altogether, our data indicates that nintedanib overcame corticosteroid resistance pulmonary fibrosis induced by bleomycin." @default.
- W4200089999 created "2021-12-31" @default.
- W4200089999 creator A5034387560 @default.
- W4200089999 creator A5035036089 @default.
- W4200089999 creator A5074792340 @default.
- W4200089999 date "2021-09-13" @default.
- W4200089999 modified "2023-09-27" @default.
- W4200089999 title "Nintedanib reduces corticosteroid resistance pulmonary fibrosis induced by bleomycin in mice by increasing the expression of β3 & β6 integrins" @default.
- W4200089999 doi "https://doi.org/10.21203/rs.3.rs-898520/v1" @default.
- W4200089999 hasPublicationYear "2021" @default.
- W4200089999 type Work @default.
- W4200089999 citedByCount "0" @default.
- W4200089999 crossrefType "posted-content" @default.
- W4200089999 hasAuthorship W4200089999A5034387560 @default.
- W4200089999 hasAuthorship W4200089999A5035036089 @default.
- W4200089999 hasAuthorship W4200089999A5074792340 @default.
- W4200089999 hasBestOaLocation W42000899991 @default.
- W4200089999 hasConcept C126322002 @default.
- W4200089999 hasConcept C134018914 @default.
- W4200089999 hasConcept C142724271 @default.
- W4200089999 hasConcept C204232928 @default.
- W4200089999 hasConcept C2776151105 @default.
- W4200089999 hasConcept C2776232574 @default.
- W4200089999 hasConcept C2776694085 @default.
- W4200089999 hasConcept C2776804153 @default.
- W4200089999 hasConcept C2777714996 @default.
- W4200089999 hasConcept C2778401633 @default.
- W4200089999 hasConcept C2779797417 @default.
- W4200089999 hasConcept C2780559512 @default.
- W4200089999 hasConcept C2781244666 @default.
- W4200089999 hasConcept C71924100 @default.
- W4200089999 hasConceptScore W4200089999C126322002 @default.
- W4200089999 hasConceptScore W4200089999C134018914 @default.
- W4200089999 hasConceptScore W4200089999C142724271 @default.
- W4200089999 hasConceptScore W4200089999C204232928 @default.
- W4200089999 hasConceptScore W4200089999C2776151105 @default.
- W4200089999 hasConceptScore W4200089999C2776232574 @default.
- W4200089999 hasConceptScore W4200089999C2776694085 @default.
- W4200089999 hasConceptScore W4200089999C2776804153 @default.
- W4200089999 hasConceptScore W4200089999C2777714996 @default.
- W4200089999 hasConceptScore W4200089999C2778401633 @default.
- W4200089999 hasConceptScore W4200089999C2779797417 @default.
- W4200089999 hasConceptScore W4200089999C2780559512 @default.
- W4200089999 hasConceptScore W4200089999C2781244666 @default.
- W4200089999 hasConceptScore W4200089999C71924100 @default.
- W4200089999 hasLocation W42000899991 @default.
- W4200089999 hasLocation W42000899992 @default.
- W4200089999 hasOpenAccess W4200089999 @default.
- W4200089999 hasPrimaryLocation W42000899991 @default.
- W4200089999 hasRelatedWork W1932847320 @default.
- W4200089999 hasRelatedWork W1968348717 @default.
- W4200089999 hasRelatedWork W2004456215 @default.
- W4200089999 hasRelatedWork W2137957356 @default.
- W4200089999 hasRelatedWork W2165311863 @default.
- W4200089999 hasRelatedWork W2171894286 @default.
- W4200089999 hasRelatedWork W2279004992 @default.
- W4200089999 hasRelatedWork W2610901668 @default.
- W4200089999 hasRelatedWork W3032476802 @default.
- W4200089999 hasRelatedWork W3159249807 @default.
- W4200089999 isParatext "false" @default.
- W4200089999 isRetracted "false" @default.
- W4200089999 workType "article" @default.