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- W4200096797 abstract "Spinal cord injury (SCI) is a life-threatening condition that leads to permanent disability with partial or complete loss of motor, sensory, and autonomic functions. SCI is usually caused by initial mechanical insult, followed by a cascade of several neuroinflammation and structural changes. For ameliorating the neuroinflammatory cascades, MSC has been regarded as a therapeutic agent. The animal SCI research has demonstrated that MSC can be a valuable therapeutic agent with several growth factors and cytokines that may induce anti-inflammatory and regenerative effects. However, the therapeutic efficacy of MSCs in animal SCI models is inconsistent, and the optimal method of MSCs remains debatable. Moreover, there are several limitations to developing these therapeutic agents for humans. Therefore, identifying novel agents for regenerative medicine is necessary. Extracellular vesicles are a novel source for regenerative medicine; they possess nucleic acids, functional proteins, and bioactive lipids and perform various functions, including damaged tissue repair, immune response regulation, and reduction of inflammation. MSC-derived exosomes have advantages over MSCs, including small dimensions, low immunogenicity, and no need for additional procedures for culture expansion or delivery. Certain studies have demonstrated that MSC-derived extracellular vesicles (EVs), including exosomes, exhibit outstanding chondroprotective and anti-inflammatory effects. Therefore, we reviewed the principles and patho-mechanisms and summarized the research outcomes of MSCs and MSC-derived EVs for SCI, reported to date." @default.
- W4200096797 created "2021-12-31" @default.
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- W4200096797 date "2021-12-20" @default.
- W4200096797 modified "2023-10-03" @default.
- W4200096797 title "Therapeutic Potential of Mesenchymal Stem Cells (MSCs) and MSC-Derived Extracellular Vesicles for the Treatment of Spinal Cord Injury" @default.
- W4200096797 cites W144423133 @default.
- W4200096797 cites W1490526869 @default.
- W4200096797 cites W1491255615 @default.
- W4200096797 cites W1500809101 @default.
- W4200096797 cites W1516460285 @default.
- W4200096797 cites W1591473290 @default.
- W4200096797 cites W1600024584 @default.
- W4200096797 cites W1621337337 @default.
- W4200096797 cites W1621991227 @default.
- W4200096797 cites W1631348406 @default.
- W4200096797 cites W1702865473 @default.
- W4200096797 cites W1716053759 @default.
- W4200096797 cites W1806641500 @default.
- W4200096797 cites W1835345305 @default.
- W4200096797 cites W1839853984 @default.
- W4200096797 cites W1904685232 @default.
- W4200096797 cites W1962605277 @default.
- W4200096797 cites W1964108710 @default.
- W4200096797 cites W1966388375 @default.
- W4200096797 cites W1966778303 @default.
- W4200096797 cites W1967270924 @default.
- W4200096797 cites W1972658883 @default.
- W4200096797 cites W1972746349 @default.
- W4200096797 cites W1975614567 @default.
- W4200096797 cites W1975822477 @default.
- W4200096797 cites W1979043688 @default.
- W4200096797 cites W1981287437 @default.
- W4200096797 cites W1982561969 @default.
- W4200096797 cites W1982598770 @default.
- W4200096797 cites W1986005801 @default.
- W4200096797 cites W1988375959 @default.
- W4200096797 cites W1990366000 @default.
- W4200096797 cites W1990597414 @default.
- W4200096797 cites W1991024347 @default.
- W4200096797 cites W1992414522 @default.
- W4200096797 cites W1993726571 @default.
- W4200096797 cites W1994645662 @default.
- W4200096797 cites W1996251887 @default.
- W4200096797 cites W1998164796 @default.
- W4200096797 cites W2004504096 @default.
- W4200096797 cites W2005001826 @default.
- W4200096797 cites W2006986081 @default.
- W4200096797 cites W2007148556 @default.
- W4200096797 cites W2007293466 @default.
- W4200096797 cites W2011708851 @default.
- W4200096797 cites W2020073243 @default.
- W4200096797 cites W2021634519 @default.
- W4200096797 cites W2023476837 @default.
- W4200096797 cites W2025291066 @default.
- W4200096797 cites W2025371271 @default.
- W4200096797 cites W2025797605 @default.
- W4200096797 cites W2031211371 @default.
- W4200096797 cites W2033335157 @default.
- W4200096797 cites W2034031487 @default.
- W4200096797 cites W2038224079 @default.
- W4200096797 cites W2038467210 @default.
- W4200096797 cites W2039533211 @default.
- W4200096797 cites W2041773411 @default.
- W4200096797 cites W2043726983 @default.
- W4200096797 cites W2045574035 @default.
- W4200096797 cites W2046525806 @default.
- W4200096797 cites W2046569869 @default.
- W4200096797 cites W2047443712 @default.
- W4200096797 cites W2053685961 @default.
- W4200096797 cites W2054633821 @default.
- W4200096797 cites W2055521188 @default.
- W4200096797 cites W2059895668 @default.
- W4200096797 cites W2060074949 @default.
- W4200096797 cites W2060578350 @default.
- W4200096797 cites W2061987394 @default.
- W4200096797 cites W2065025152 @default.
- W4200096797 cites W2069329007 @default.
- W4200096797 cites W2070829702 @default.
- W4200096797 cites W2071992113 @default.
- W4200096797 cites W2074661552 @default.
- W4200096797 cites W2074834108 @default.
- W4200096797 cites W2075806802 @default.
- W4200096797 cites W2076184989 @default.
- W4200096797 cites W2076731990 @default.
- W4200096797 cites W2082711170 @default.
- W4200096797 cites W2083948684 @default.