Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200098108> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4200098108 abstract "ABSTRACT Agonists are classified by the strength at which they bind to their target sites (affinity) and their ability to activate receptors once bound to those sites (efficacy). Efficiency is a third fundamental agonist property that is a measure of the correlation between affinity and efficacy. Efficiency is the percent of agonist binding energy that is converted into energy for receptor activation (‘gating’). In the muscle nicotinic acetylcholine receptor, agonists belong to families having discrete efficiencies of 54%, 51%, 42% or 35%. Efficiency depends on the size and composition of both the agonist and binding site, and can be estimated from, and used to interpret, concentration-response curves. A correlation between affinity and efficacy indicates that the agonist’s energy changes that take place within binding and gating processes are linked. Efficiency suggests that receptors turn on and off by progressing through a sequence of energy-linked domain rearrangements, as in a zipper." @default.
- W4200098108 created "2021-12-31" @default.
- W4200098108 creator A5064835126 @default.
- W4200098108 date "2021-12-20" @default.
- W4200098108 modified "2023-09-23" @default.
- W4200098108 title "Agonists to ions: Efficiency suggests ‘zipper’ mechanism for nicotinic receptor activation" @default.
- W4200098108 cites W1632324362 @default.
- W4200098108 cites W1950332654 @default.
- W4200098108 cites W1972994417 @default.
- W4200098108 cites W1977242895 @default.
- W4200098108 cites W2003744323 @default.
- W4200098108 cites W2005061578 @default.
- W4200098108 cites W2006067323 @default.
- W4200098108 cites W2032733145 @default.
- W4200098108 cites W2041205020 @default.
- W4200098108 cites W2043433589 @default.
- W4200098108 cites W2050347178 @default.
- W4200098108 cites W2056312592 @default.
- W4200098108 cites W2065626695 @default.
- W4200098108 cites W2080637877 @default.
- W4200098108 cites W2083375544 @default.
- W4200098108 cites W2087600888 @default.
- W4200098108 cites W2097262535 @default.
- W4200098108 cites W2135163309 @default.
- W4200098108 cites W2137421873 @default.
- W4200098108 cites W2158602973 @default.
- W4200098108 cites W2170713277 @default.
- W4200098108 cites W2170963483 @default.
- W4200098108 cites W2560121071 @default.
- W4200098108 cites W2765858904 @default.
- W4200098108 cites W2908533002 @default.
- W4200098108 cites W2909964242 @default.
- W4200098108 cites W2933443469 @default.
- W4200098108 cites W3015294141 @default.
- W4200098108 cites W3126984074 @default.
- W4200098108 cites W3130641007 @default.
- W4200098108 cites W3205569807 @default.
- W4200098108 cites W3214142599 @default.
- W4200098108 doi "https://doi.org/10.1101/2021.12.18.473297" @default.
- W4200098108 hasPublicationYear "2021" @default.
- W4200098108 type Work @default.
- W4200098108 citedByCount "0" @default.
- W4200098108 crossrefType "posted-content" @default.
- W4200098108 hasAuthorship W4200098108A5064835126 @default.
- W4200098108 hasBestOaLocation W42000981081 @default.
- W4200098108 hasConcept C105782903 @default.
- W4200098108 hasConcept C107824862 @default.
- W4200098108 hasConcept C11413529 @default.
- W4200098108 hasConcept C12554922 @default.
- W4200098108 hasConcept C170493617 @default.
- W4200098108 hasConcept C185592680 @default.
- W4200098108 hasConcept C188987157 @default.
- W4200098108 hasConcept C194544171 @default.
- W4200098108 hasConcept C2778938600 @default.
- W4200098108 hasConcept C33923547 @default.
- W4200098108 hasConcept C55493867 @default.
- W4200098108 hasConcept C58732023 @default.
- W4200098108 hasConcept C86803240 @default.
- W4200098108 hasConceptScore W4200098108C105782903 @default.
- W4200098108 hasConceptScore W4200098108C107824862 @default.
- W4200098108 hasConceptScore W4200098108C11413529 @default.
- W4200098108 hasConceptScore W4200098108C12554922 @default.
- W4200098108 hasConceptScore W4200098108C170493617 @default.
- W4200098108 hasConceptScore W4200098108C185592680 @default.
- W4200098108 hasConceptScore W4200098108C188987157 @default.
- W4200098108 hasConceptScore W4200098108C194544171 @default.
- W4200098108 hasConceptScore W4200098108C2778938600 @default.
- W4200098108 hasConceptScore W4200098108C33923547 @default.
- W4200098108 hasConceptScore W4200098108C55493867 @default.
- W4200098108 hasConceptScore W4200098108C58732023 @default.
- W4200098108 hasConceptScore W4200098108C86803240 @default.
- W4200098108 hasLocation W42000981081 @default.
- W4200098108 hasOpenAccess W4200098108 @default.
- W4200098108 hasPrimaryLocation W42000981081 @default.
- W4200098108 hasRelatedWork W1999125786 @default.
- W4200098108 hasRelatedWork W1999868125 @default.
- W4200098108 hasRelatedWork W2025874457 @default.
- W4200098108 hasRelatedWork W2070107288 @default.
- W4200098108 hasRelatedWork W2117767839 @default.
- W4200098108 hasRelatedWork W2138375529 @default.
- W4200098108 hasRelatedWork W2146952421 @default.
- W4200098108 hasRelatedWork W2155524601 @default.
- W4200098108 hasRelatedWork W2168988224 @default.
- W4200098108 hasRelatedWork W4200098108 @default.
- W4200098108 isParatext "false" @default.
- W4200098108 isRetracted "false" @default.
- W4200098108 workType "article" @default.