FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200100823> ?p ?o ?g. }

• W4200100823 endingPage "2076" @default.
• W4200100823 startingPage "2076" @default.
• W4200100823 abstract "During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis. The aqueous drug formulation subsequently spreads over the inner vial wall, while a cold gas flow is used for cooling and freezing the product. In this work, a mechanistic model was developed describing the energy transfer during each phase of spin freezing in order to predict the vial and product temperature change over time. The uncertainty in the model input parameters was included via uncertainty analysis, while global sensitivity analysis was used to assign the uncertainty in the model output to the different sources of uncertainty in the model input. The model was verified, and the prediction interval corresponded to the vial temperature profiles obtained from experimental data, within the limits of the uncertainty interval. The uncertainty in the model prediction was mainly explained (>96% of uncertainty) by the uncertainty in the heat transfer coefficient, the gas temperature measurement, and the equilibrium temperature. The developed model was also applied in order to set and control a desired vial temperature profile during spin freezing. Applying this model in-line to a continuous freeze-drying process may alleviate some of the disadvantages related to batch freeze-drying, where control over the freezing step is generally poor." @default.
• W4200100823 created "2021-12-31" @default.
• W4200100823 creator A5016447297 @default.
• W4200100823 creator A5016590344 @default.
• W4200100823 creator A5020618509 @default.
• W4200100823 creator A5026051259 @default.
• W4200100823 creator A5030362122 @default.
• W4200100823 creator A5037516083 @default.
• W4200100823 creator A5044677428 @default.
• W4200100823 creator A5054644537 @default.
• W4200100823 creator A5070992881 @default.
• W4200100823 creator A5090876590 @default.
• W4200100823 date "2021-12-03" @default.
• W4200100823 modified "2023-09-26" @default.
• W4200100823 title "Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying" @default.
• W4200100823 cites W1574935467 @default.
• W4200100823 cites W1972596775 @default.
• W4200100823 cites W1977066869 @default.
• W4200100823 cites W1980211543 @default.
• W4200100823 cites W1981449423 @default.
• W4200100823 cites W1987205432 @default.
• W4200100823 cites W1990861883 @default.
• W4200100823 cites W1991468104 @default.
• W4200100823 cites W2000378779 @default.
• W4200100823 cites W2018214909 @default.
• W4200100823 cites W2025960550 @default.
• W4200100823 cites W2028883025 @default.
• W4200100823 cites W2034204131 @default.
• W4200100823 cites W2036563892 @default.
• W4200100823 cites W2040812195 @default.
• W4200100823 cites W2054956418 @default.
• W4200100823 cites W2061774732 @default.
• W4200100823 cites W2074061140 @default.
• W4200100823 cites W2089894742 @default.
• W4200100823 cites W2130816910 @default.
• W4200100823 cites W2198074726 @default.
• W4200100823 cites W2300565961 @default.
• W4200100823 cites W2728861461 @default.
• W4200100823 cites W2760567406 @default.
• W4200100823 cites W2774231645 @default.
• W4200100823 cites W2790005528 @default.
• W4200100823 cites W2793552456 @default.
• W4200100823 cites W2897266547 @default.
• W4200100823 cites W2902512852 @default.
• W4200100823 cites W2918637572 @default.
• W4200100823 cites W2999677244 @default.
• W4200100823 cites W3025002453 @default.
• W4200100823 cites W3110149129 @default.
• W4200100823 cites W3150184806 @default.
• W4200100823 cites W3157272663 @default.
• W4200100823 cites W345263468 @default.
• W4200100823 cites W4251356425 @default.
• W4200100823 cites W4253184129 @default.
• W4200100823 doi "https://doi.org/10.3390/pharmaceutics13122076" @default.
• W4200100823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34959357" @default.
• W4200100823 hasPublicationYear "2021" @default.
• W4200100823 type Work @default.
• W4200100823 citedByCount "5" @default.
• W4200100823 countsByYear W42001008232022 @default.
• W4200100823 countsByYear W42001008232023 @default.
• W4200100823 crossrefType "journal-article" @default.
• W4200100823 hasAuthorship W4200100823A5016447297 @default.
• W4200100823 hasAuthorship W4200100823A5016590344 @default.
• W4200100823 hasAuthorship W4200100823A5020618509 @default.
• W4200100823 hasAuthorship W4200100823A5026051259 @default.
• W4200100823 hasAuthorship W4200100823A5030362122 @default.
• W4200100823 hasAuthorship W4200100823A5037516083 @default.
• W4200100823 hasAuthorship W4200100823A5044677428 @default.
• W4200100823 hasAuthorship W4200100823A5054644537 @default.
• W4200100823 hasAuthorship W4200100823A5070992881 @default.
• W4200100823 hasAuthorship W4200100823A5090876590 @default.
• W4200100823 hasBestOaLocation W42001008231 @default.
• W4200100823 hasConcept C121332964 @default.
• W4200100823 hasConcept C127413603 @default.
• W4200100823 hasConcept C177803969 @default.
• W4200100823 hasConcept C185592680 @default.
• W4200100823 hasConcept C18762648 @default.
• W4200100823 hasConcept C192562407 @default.
• W4200100823 hasConcept C21200559 @default.
• W4200100823 hasConcept C21880701 @default.
• W4200100823 hasConcept C24326235 @default.
• W4200100823 hasConcept C41008148 @default.
• W4200100823 hasConcept C43617362 @default.
• W4200100823 hasConcept C44154836 @default.
• W4200100823 hasConcept C50517652 @default.
• W4200100823 hasConcept C536315585 @default.
• W4200100823 hasConcept C57879066 @default.
• W4200100823 hasConcept C84199377 @default.
• W4200100823 hasConcept C97355855 @default.
• W4200100823 hasConceptScore W4200100823C121332964 @default.
• W4200100823 hasConceptScore W4200100823C127413603 @default.
• W4200100823 hasConceptScore W4200100823C177803969 @default.
• W4200100823 hasConceptScore W4200100823C185592680 @default.
• W4200100823 hasConceptScore W4200100823C18762648 @default.
• W4200100823 hasConceptScore W4200100823C192562407 @default.
• W4200100823 hasConceptScore W4200100823C21200559 @default.
• W4200100823 hasConceptScore W4200100823C21880701 @default.
• W4200100823 hasConceptScore W4200100823C24326235 @default.

• next