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- W4200102773 endingPage "186" @default.
- W4200102773 startingPage "176" @default.
- W4200102773 abstract "The number of atomic-resolution structures of disease-associated amyloids has greatly increased in recent years. These structures have confirmed not only the polymorphic nature of amyloids but also the association of specific polymorphs to particular proteinopathies. These observations are strengthening the view that amyloid polymorphism is a marker for specific pathological subtypes (e.g. in tauopathies or synucleinopathies). The nature of this association and how it relates to the selective cellular vulnerability of amyloid nucleation, propagation and toxicity are still unclear. Here, we provide an overview of the mechanistic insights provided by recent patient-derived amyloid structures. We discuss the framework organisation of amyloid polymorphism and how heterotypic amyloid interactions with the physiological environment could modify the solubility and assembly of amyloidogenic proteins. We conclude by hypothesising how such interactions could contribute to selective cellular vulnerability." @default.
- W4200102773 created "2021-12-31" @default.
- W4200102773 creator A5008256216 @default.
- W4200102773 creator A5031589452 @default.
- W4200102773 creator A5060221835 @default.
- W4200102773 date "2022-02-01" @default.
- W4200102773 modified "2023-09-29" @default.
- W4200102773 title "Heterotypic amyloid interactions: Clues to polymorphic bias and selective cellular vulnerability?" @default.
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