FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200103008> ?p ?o ?g. }

• W4200103008 abstract "Intramuscular fat (i.m.) is an adipose tissue that is deposited between muscle bundles. An important type of post-transcriptional regulatory factor, miRNAs, has been observed as an important regulator that can regulate gene expression and cell differentiation through specific binding with target genes, which is the pivotal way determining intramuscular fat deposition. Thus, this study intends to use RT-PCR, cell culture, liposome transfection, real-time fluorescent quantitative PCR (qPCR), dual luciferase reporter systems, and other biological methods clarifying the possible mechanisms on goat intramuscular preadipocyte differentiation that is regulated by miR-214-5p. Ultimately, our results showed that the expression level of miR-214-5p peaked at 48 h after the goat intramuscular preadipocytes were induced for adipogenesis. Furthermore, after inhibition of the expression of miR-214-5p, the accumulation of lipid droplets and adipocyte differentiation in goat intramuscular adipocytes were promoted by the way of up-regulation of the expression level of lipoprotein lipase (LPL) (p < 0.05) and peroxisome proliferator-activated receptor gamma (PPARγ) (p < 0.01) but inhibited the expression of hormone-sensitive lipase (HSL) (p < 0.01). Subsequently, our study confirmed that Krüppel-like factor 12 (KLF12) was the target gene of miR-214-5p. Inhibition of the expression of KLF12 promoted adipocyte differentiation and lipid accumulation by upregulation of the expression of LPL and CCAAT/enhancer binding protein (C/EBPα) (p < 0.01). Overall, these results indicated that miR-214-5p and its target gene KLF12 were negative regulators in progression of goat preadipocyte differentiation. Our research results provided an experimental basis for finally revealing the mechanism of miR-214-5p in adipocytes." @default.
• W4200103008 created "2021-12-31" @default.
• W4200103008 creator A5002601186 @default.
• W4200103008 creator A5003866201 @default.
• W4200103008 creator A5017938965 @default.
• W4200103008 creator A5042591556 @default.
• W4200103008 creator A5044067189 @default.
• W4200103008 creator A5091610124 @default.
• W4200103008 date "2021-12-22" @default.
• W4200103008 modified "2023-10-17" @default.
• W4200103008 title "miR-214-5p Regulating Differentiation of Intramuscular Preadipocytes in Goats via Targeting KLF12" @default.
• W4200103008 cites W1970120507 @default.
• W4200103008 cites W1994370611 @default.
• W4200103008 cites W2016701686 @default.
• W4200103008 cites W2032215506 @default.
• W4200103008 cites W2038069256 @default.
• W4200103008 cites W2052609811 @default.
• W4200103008 cites W2053003053 @default.
• W4200103008 cites W2067187286 @default.
• W4200103008 cites W2089647450 @default.
• W4200103008 cites W2094722560 @default.
• W4200103008 cites W2097511872 @default.
• W4200103008 cites W2100414311 @default.
• W4200103008 cites W2128731054 @default.
• W4200103008 cites W2133613657 @default.
• W4200103008 cites W2138344908 @default.
• W4200103008 cites W2139326439 @default.
• W4200103008 cites W2169970290 @default.
• W4200103008 cites W2171139781 @default.
• W4200103008 cites W2284659436 @default.
• W4200103008 cites W2306895977 @default.
• W4200103008 cites W2336804014 @default.
• W4200103008 cites W2611752142 @default.
• W4200103008 cites W2615353723 @default.
• W4200103008 cites W2790118830 @default.
• W4200103008 cites W282221905 @default.
• W4200103008 cites W2883446651 @default.
• W4200103008 cites W2892484964 @default.
• W4200103008 cites W2895135832 @default.
• W4200103008 cites W2959373541 @default.
• W4200103008 cites W2966445705 @default.
• W4200103008 cites W2974005012 @default.
• W4200103008 cites W2982216706 @default.
• W4200103008 cites W2998163040 @default.
• W4200103008 cites W3011584092 @default.
• W4200103008 cites W3021475604 @default.
• W4200103008 cites W3093174760 @default.
• W4200103008 cites W4211237789 @default.
• W4200103008 doi "https://doi.org/10.3389/fgene.2021.748629" @default.
• W4200103008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35003206" @default.
• W4200103008 hasPublicationYear "2021" @default.
• W4200103008 type Work @default.
• W4200103008 citedByCount "5" @default.
• W4200103008 countsByYear W42001030082022 @default.
• W4200103008 countsByYear W42001030082023 @default.
• W4200103008 crossrefType "journal-article" @default.
• W4200103008 hasAuthorship W4200103008A5002601186 @default.
• W4200103008 hasAuthorship W4200103008A5003866201 @default.
• W4200103008 hasAuthorship W4200103008A5017938965 @default.
• W4200103008 hasAuthorship W4200103008A5042591556 @default.
• W4200103008 hasAuthorship W4200103008A5044067189 @default.
• W4200103008 hasAuthorship W4200103008A5091610124 @default.
• W4200103008 hasBestOaLocation W42001030081 @default.
• W4200103008 hasConcept C104317684 @default.
• W4200103008 hasConcept C111335760 @default.
• W4200103008 hasConcept C122927707 @default.
• W4200103008 hasConcept C127561419 @default.
• W4200103008 hasConcept C134018914 @default.
• W4200103008 hasConcept C148738053 @default.
• W4200103008 hasConcept C150194340 @default.
• W4200103008 hasConcept C161733203 @default.
• W4200103008 hasConcept C171089720 @default.
• W4200103008 hasConcept C185592680 @default.
• W4200103008 hasConcept C25095133 @default.
• W4200103008 hasConcept C2776175234 @default.
• W4200103008 hasConcept C2776635132 @default.
• W4200103008 hasConcept C54009773 @default.
• W4200103008 hasConcept C55493867 @default.
• W4200103008 hasConcept C86803240 @default.
• W4200103008 hasConcept C94879076 @default.
• W4200103008 hasConcept C95444343 @default.
• W4200103008 hasConceptScore W4200103008C104317684 @default.
• W4200103008 hasConceptScore W4200103008C111335760 @default.
• W4200103008 hasConceptScore W4200103008C122927707 @default.
• W4200103008 hasConceptScore W4200103008C127561419 @default.
• W4200103008 hasConceptScore W4200103008C134018914 @default.
• W4200103008 hasConceptScore W4200103008C148738053 @default.
• W4200103008 hasConceptScore W4200103008C150194340 @default.
• W4200103008 hasConceptScore W4200103008C161733203 @default.
• W4200103008 hasConceptScore W4200103008C171089720 @default.
• W4200103008 hasConceptScore W4200103008C185592680 @default.
• W4200103008 hasConceptScore W4200103008C25095133 @default.
• W4200103008 hasConceptScore W4200103008C2776175234 @default.
• W4200103008 hasConceptScore W4200103008C2776635132 @default.
• W4200103008 hasConceptScore W4200103008C54009773 @default.
• W4200103008 hasConceptScore W4200103008C55493867 @default.
• W4200103008 hasConceptScore W4200103008C86803240 @default.
• W4200103008 hasConceptScore W4200103008C94879076 @default.
• W4200103008 hasConceptScore W4200103008C95444343 @default.
• W4200103008 hasLocation W42001030081 @default.

• next