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- W4200103150 endingPage "177" @default.
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- W4200103150 abstract "The prevalence of diabetes mellitus throughout the world has increased dramatically over the recent past, and is projected to affect 629 million people by 2045. Advanced understanding of pathophysiology of diabetes has facilitated development of various antidiabetic agents which target specific metabolic pathways. However, one of the major concerns associated with diabetes relates to a corresponding epidemic of devastating macrovascular and microvascular complications, which result in increased mortality and overall reduction in the life quality of patients. Although our understanding of the complexities of diabetic micro complications (nephropathy, neuropathy, and retinopathy) has substantially increased over the past decade, the distinctive mechanisms underlying these complications in type 1 and type 2 diabetes remain unknown. While many facets of diabetic microvascular complications are still not fully understood, animal models of disease have played an important role in the understanding etiology, disease progression, identification of drug targets, and evaluation of new drugs in vivo. Currently, a number of animal models are being utilized for the development of diabetes and its microvascular complications, but not a single model mimics all features of pathophysiology and natural history of diabetes and its microvascular complications similar to that of the human conditions. Hence, proper selection of animal model, which mimic the clinical pathophysiology, is vital to understand the entire pathophysiological mechanisms and develop new therapeutics. This review summarizes the putative mechanisms involved in the development of diabetic microvascular complications and widely used animal models with reference to utility and limitations of these models for the study of these complications." @default.
- W4200103150 created "2021-12-31" @default.
- W4200103150 creator A5001516293 @default.
- W4200103150 creator A5035875919 @default.
- W4200103150 creator A5056067436 @default.
- W4200103150 date "2022-01-01" @default.
- W4200103150 modified "2023-10-16" @default.
- W4200103150 title "Selection of experimental models mimicking human pathophysiology for diabetic microvascular complications" @default.
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