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- W4200103490 endingPage "6108" @default.
- W4200103490 startingPage "6108" @default.
- W4200103490 abstract "MicroRNAs (miRNAs) are linear single-stranded non-coding RNAs oligonucleotides, widely distributed in cells, playing a key role as regulators of gene expression at post-transcriptional level. Circular RNAs (circRNAs) are single-stranded RNA oligonucleotides forming a covalently closed continuous loop, which confers them a high structural stability and which may code for proteins or act as gene regulators. Abnormal levels or dysregulation of miRNA or circRNA are linked to several cancerous pathologies, so that they are receiving a large attention as diagnostic and prognostic tools. Some miRNAs and circRNAs are strongly involved in the regulatory networks of the transcription factor p53, which plays a pivotal role as tumor suppressor. Overexpression of miRNAs and/or circRNAs, as registered in a number of cancers, is associated to a concomitant inhibition of the p53 onco-suppressive function. Among other mechanisms, it was recently suggested that a functional inhibition of p53 could arise from a direct interaction between p53 and oncogenic miRNAs or circRNAs; a mechanism that might be reminiscent of the p53 inhibition by some E3 ubiquitin ligase such as MDM2 and COP1. Such evidence might deserve important implications for restoring the p53 anticancer functionality, and pave the way to intriguing perspectives for novel therapeutic strategies. In the present paper, the experimental evidence of the interaction between p53 and miRNAs and/or circRNAs is reviewed and discussed in connection with the development of new anticancer approaches." @default.
- W4200103490 created "2021-12-31" @default.
- W4200103490 creator A5036589086 @default.
- W4200103490 creator A5039099214 @default.
- W4200103490 date "2021-12-03" @default.
- W4200103490 modified "2023-10-16" @default.
- W4200103490 title "Direct Interaction of miRNA and circRNA with the Oncosuppressor p53: An Intriguing Perspective in Cancer Research" @default.
- W4200103490 cites W144423133 @default.
- W4200103490 cites W1557444671 @default.
- W4200103490 cites W1650797637 @default.
- W4200103490 cites W1926568554 @default.
- W4200103490 cites W1937707692 @default.
- W4200103490 cites W1973821009 @default.
- W4200103490 cites W1976261939 @default.
- W4200103490 cites W1976295398 @default.
- W4200103490 cites W2008605553 @default.
- W4200103490 cites W2012174750 @default.
- W4200103490 cites W2013721931 @default.
- W4200103490 cites W2014946489 @default.
- W4200103490 cites W2017919052 @default.
- W4200103490 cites W2025722611 @default.
- W4200103490 cites W2028374237 @default.
- W4200103490 cites W2030133817 @default.
- W4200103490 cites W2033383787 @default.
- W4200103490 cites W2033667966 @default.
- W4200103490 cites W2034305079 @default.
- W4200103490 cites W2037312364 @default.
- W4200103490 cites W2058615001 @default.
- W4200103490 cites W2058835062 @default.
- W4200103490 cites W2058947924 @default.
- W4200103490 cites W2059185804 @default.
- W4200103490 cites W2060972565 @default.
- W4200103490 cites W2064165694 @default.
- W4200103490 cites W2077064224 @default.
- W4200103490 cites W2084475063 @default.
- W4200103490 cites W2094607113 @default.
- W4200103490 cites W2096276671 @default.
- W4200103490 cites W2097616194 @default.
- W4200103490 cites W2099907467 @default.
- W4200103490 cites W2112396116 @default.
- W4200103490 cites W2113039629 @default.
- W4200103490 cites W2117391818 @default.
- W4200103490 cites W2125813323 @default.
- W4200103490 cites W2133959309 @default.
- W4200103490 cites W2134536196 @default.
- W4200103490 cites W2134747634 @default.
- W4200103490 cites W2137847014 @default.
- W4200103490 cites W2138068224 @default.
- W4200103490 cites W2139002825 @default.
- W4200103490 cites W2141549067 @default.
- W4200103490 cites W2147806662 @default.
- W4200103490 cites W2154241726 @default.
- W4200103490 cites W2156299289 @default.
- W4200103490 cites W2162674813 @default.
- W4200103490 cites W2173135538 @default.
- W4200103490 cites W2250540144 @default.
- W4200103490 cites W2298001438 @default.
- W4200103490 cites W2301864188 @default.
- W4200103490 cites W2341291028 @default.
- W4200103490 cites W2345249791 @default.
- W4200103490 cites W2400474752 @default.
- W4200103490 cites W2418616859 @default.
- W4200103490 cites W2511152819 @default.
- W4200103490 cites W2516126594 @default.
- W4200103490 cites W2518630307 @default.
- W4200103490 cites W2531297636 @default.
- W4200103490 cites W2557141539 @default.
- W4200103490 cites W2598674107 @default.
- W4200103490 cites W2605139631 @default.
- W4200103490 cites W2615136515 @default.
- W4200103490 cites W2624817122 @default.
- W4200103490 cites W2729904891 @default.
- W4200103490 cites W2736520162 @default.
- W4200103490 cites W2744268790 @default.
- W4200103490 cites W2756148299 @default.
- W4200103490 cites W2767326431 @default.
- W4200103490 cites W2770981154 @default.
- W4200103490 cites W2781732354 @default.
- W4200103490 cites W2804601578 @default.
- W4200103490 cites W2804645484 @default.
- W4200103490 cites W2810062789 @default.
- W4200103490 cites W282221905 @default.
- W4200103490 cites W2892630678 @default.
- W4200103490 cites W2903723297 @default.
- W4200103490 cites W2904049988 @default.
- W4200103490 cites W2912017471 @default.
- W4200103490 cites W2912953395 @default.
- W4200103490 cites W2913417482 @default.
- W4200103490 cites W2914026182 @default.
- W4200103490 cites W2919470997 @default.
- W4200103490 cites W2920207301 @default.
- W4200103490 cites W2949592765 @default.
- W4200103490 cites W2988290061 @default.
- W4200103490 cites W2988695675 @default.
- W4200103490 cites W3006026466 @default.
- W4200103490 cites W3008121881 @default.
- W4200103490 cites W3010881000 @default.
- W4200103490 cites W3020855961 @default.