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- W4200106534 abstract "Antimicrobial chemotherapy can fail to eradicate the pathogen, even in the absence of antimicrobial resistance. Persisting pathogens can subsequently cause relapsing diseases. In vitro studies suggest various mechanisms of antibiotic persistence, but their in vivo relevance remains unclear because of the difficulty of studying scarce pathogen survivors in complex host tissues. Here, we localized and characterized rare surviving Salmonella in mouse spleen using high-resolution whole-organ tomography. Chemotherapy cleared >99.5% of the Salmonella but was inefficient against a small Salmonella subset in the white pulp. Previous models could not explain these findings: drug exposure was adequate, Salmonella continued to replicate, and host stresses induced only limited Salmonella drug tolerance. Instead, antimicrobial clearance required support of Salmonella-killing neutrophils and monocytes, and the density of such cells was lower in the white pulp than in other spleen compartments containing higher Salmonella loads. Neutrophil densities declined further during treatment in response to receding Salmonella loads, resulting in insufficient support for Salmonella clearance from the white pulp and eradication failure. However, adjunctive therapies sustaining inflammatory support enabled effective clearance. These results identify uneven Salmonella tissue colonization and spatiotemporal inflammation dynamics as main causes of Salmonella persistence and establish a powerful approach to investigate scarce but impactful pathogen subsets in complex host environments." @default.
- W4200106534 created "2021-12-31" @default.
- W4200106534 creator A5011526532 @default.
- W4200106534 creator A5014519681 @default.
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- W4200106534 creator A5043932340 @default.
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- W4200106534 creator A5072362581 @default.
- W4200106534 date "2021-12-15" @default.
- W4200106534 modified "2023-10-06" @default.
- W4200106534 title "Tissue compartmentalization enables <i>Salmonella</i> persistence during chemotherapy" @default.
- W4200106534 cites W1414898727 @default.
- W4200106534 cites W1568314805 @default.
- W4200106534 cites W1591854344 @default.
- W4200106534 cites W1593354790 @default.
- W4200106534 cites W1641628118 @default.
- W4200106534 cites W1911025719 @default.
- W4200106534 cites W1952346449 @default.
- W4200106534 cites W1973852640 @default.
- W4200106534 cites W1973910115 @default.
- W4200106534 cites W1974053222 @default.
- W4200106534 cites W1981678962 @default.
- W4200106534 cites W1983076976 @default.
- W4200106534 cites W1989549652 @default.
- W4200106534 cites W1991860284 @default.
- W4200106534 cites W1993310127 @default.
- W4200106534 cites W1993314700 @default.
- W4200106534 cites W1994812540 @default.
- W4200106534 cites W1995104906 @default.
- W4200106534 cites W2002168329 @default.
- W4200106534 cites W2004753123 @default.
- W4200106534 cites W2006734531 @default.
- W4200106534 cites W2009275634 @default.
- W4200106534 cites W2014466662 @default.
- W4200106534 cites W2018038850 @default.
- W4200106534 cites W2018349181 @default.
- W4200106534 cites W2019147598 @default.
- W4200106534 cites W2026283215 @default.
- W4200106534 cites W2026827111 @default.
- W4200106534 cites W2028103501 @default.
- W4200106534 cites W2032893012 @default.
- W4200106534 cites W2034408518 @default.
- W4200106534 cites W2039045853 @default.
- W4200106534 cites W2042048278 @default.
- W4200106534 cites W2044917835 @default.
- W4200106534 cites W2048991954 @default.
- W4200106534 cites W2054261500 @default.
- W4200106534 cites W2054870083 @default.
- W4200106534 cites W2058725387 @default.
- W4200106534 cites W2066724209 @default.
- W4200106534 cites W2067130929 @default.
- W4200106534 cites W2068301725 @default.
- W4200106534 cites W2070745850 @default.
- W4200106534 cites W2075756658 @default.
- W4200106534 cites W2075917440 @default.
- W4200106534 cites W2077922242 @default.
- W4200106534 cites W2085698705 @default.
- W4200106534 cites W2096959582 @default.
- W4200106534 cites W2098992986 @default.
- W4200106534 cites W2101366952 @default.
- W4200106534 cites W2103723759 @default.
- W4200106534 cites W2106100723 @default.
- W4200106534 cites W2110760619 @default.
- W4200106534 cites W2114629994 @default.
- W4200106534 cites W2114877749 @default.
- W4200106534 cites W2118307170 @default.
- W4200106534 cites W2118904810 @default.
- W4200106534 cites W2123095717 @default.
- W4200106534 cites W2123106908 @default.
- W4200106534 cites W2123152720 @default.
- W4200106534 cites W2126552247 @default.
- W4200106534 cites W2131867987 @default.
- W4200106534 cites W2133505559 @default.
- W4200106534 cites W2146544162 @default.
- W4200106534 cites W2147264575 @default.
- W4200106534 cites W2158084007 @default.
- W4200106534 cites W2159838688 @default.
- W4200106534 cites W2160319303 @default.
- W4200106534 cites W2165250323 @default.
- W4200106534 cites W2166299253 @default.
- W4200106534 cites W2167425482 @default.
- W4200106534 cites W2180357773 @default.
- W4200106534 cites W2277513779 @default.
- W4200106534 cites W2285753024 @default.
- W4200106534 cites W2408801380 @default.
- W4200106534 cites W2412315328 @default.
- W4200106534 cites W2413162567 @default.
- W4200106534 cites W2414753072 @default.
- W4200106534 cites W2498679748 @default.
- W4200106534 cites W2510407367 @default.
- W4200106534 cites W2515497383 @default.
- W4200106534 cites W2532005031 @default.
- W4200106534 cites W2578718144 @default.
- W4200106534 cites W2584925611 @default.
- W4200106534 cites W2586386056 @default.
- W4200106534 cites W2591498398 @default.
- W4200106534 cites W2592110806 @default.
- W4200106534 cites W2607462092 @default.
- W4200106534 cites W2617852583 @default.