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• W4200109401 endingPage "526" @default.
• W4200109401 startingPage "514" @default.
• W4200109401 abstract "Transcription factors (TFs) regulate gene expression by binding to DNA sequences and modulating transcriptional activity through their effector domains. Despite the central role of effector domains in TF function, there is a current lack of a comprehensive resource and characterization of effector domains. Here, we provide a catalog of 924 effector domains across 594 human TFs. Using this catalog, we characterized the amino acid composition of effector domains, their conservation across species and across the human population, and their roles in human diseases. Furthermore, we provide a classification system for effector domains that constitutes a valuable resource and a blueprint for future experimental studies of TF effector domain function." @default.
• W4200109401 created "2021-12-31" @default.
• W4200109401 creator A5012308311 @default.
• W4200109401 creator A5025220879 @default.
• W4200109401 creator A5026316236 @default.
• W4200109401 creator A5033159424 @default.
• W4200109401 creator A5058067277 @default.
• W4200109401 creator A5062718875 @default.
• W4200109401 creator A5087917956 @default.
• W4200109401 creator A5089216319 @default.
• W4200109401 date "2022-02-01" @default.
• W4200109401 modified "2023-10-18" @default.
• W4200109401 title "Compendium of human transcription factor effector domains" @default.
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