FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200112912> ?p ?o ?g. }

• W4200112912 endingPage "475" @default.
• W4200112912 startingPage "465" @default.
• W4200112912 abstract "Canine histiocytic proliferative disorders include reactive diseases (histiocytosis) and neoplastic diseases (histiocytic sarcoma [HS]), however discrimination is challenging due to their overlapping pathological features. In the present study, novel cell lines and xenograft mouse models of systemic histiocytosis (SyH) and disseminated HS were established, and examined together with cell lines previously established from localized HS and Langerhans cell histiocytosis (LCH). The chromosomal numbers of the SyH and HS cell lines were abnormal, and their population doubling time and morphological features were comparable. Immunophenotypically, SyH and HS cells were CD204+/E-cadherin+ in vitro and in vivo, like their original tissues. Western blot analysis for E-cadherin revealed an immunopositive band of full-length E-cadherin (120 kDa) in cultured cells of localized HS and LCH but not in disseminated HS and SyH; expression level was weaker in localized HS than in LCH. An immunopositive band of fragmented E-cadherin (45 kDa) was detected in cell lines of disseminated HS and SyH. These results suggest that cultured SyH cells have features that are similar to disseminated HS, including chromosomal aberration, high proliferation activity, weak cell adhesion, and expression of fragmented E-cadherin. Fragmentation of the E-cadherin cell adhesion molecule may be associated with the loss of cell adhesion and increased abilities of invasion and migration of neoplastic cells. The established cell lines and xenograft mouse models will aid in understanding the pathogenesis and developing novel treatments of canine histiocytic proliferative disorders." @default.
• W4200112912 created "2021-12-31" @default.
• W4200112912 creator A5004893002 @default.
• W4200112912 creator A5034430202 @default.
• W4200112912 creator A5035318801 @default.
• W4200112912 creator A5036422444 @default.
• W4200112912 creator A5038084347 @default.
• W4200112912 creator A5055544018 @default.
• W4200112912 creator A5065111139 @default.
• W4200112912 creator A5086535576 @default.
• W4200112912 date "2022-02-08" @default.
• W4200112912 modified "2023-10-02" @default.
• W4200112912 title "Establishment and characterisation of cell lines and xenograft mouse models of canine systemic histiocytosis and disseminated histiocytic sarcoma" @default.
• W4200112912 cites W1624109424 @default.
• W4200112912 cites W1975442047 @default.
• W4200112912 cites W1988624151 @default.
• W4200112912 cites W1989454836 @default.
• W4200112912 cites W1989556210 @default.
• W4200112912 cites W1995899370 @default.
• W4200112912 cites W2008732891 @default.
• W4200112912 cites W2014457499 @default.
• W4200112912 cites W2018439279 @default.
• W4200112912 cites W2022380333 @default.
• W4200112912 cites W2028155962 @default.
• W4200112912 cites W2030947813 @default.
• W4200112912 cites W2036111494 @default.
• W4200112912 cites W2040721753 @default.
• W4200112912 cites W2046529770 @default.
• W4200112912 cites W2053601970 @default.
• W4200112912 cites W2055764506 @default.
• W4200112912 cites W2067825854 @default.
• W4200112912 cites W2079822769 @default.
• W4200112912 cites W2086084523 @default.
• W4200112912 cites W2088764241 @default.
• W4200112912 cites W2092055986 @default.
• W4200112912 cites W2097055773 @default.
• W4200112912 cites W2106316471 @default.
• W4200112912 cites W2110444317 @default.
• W4200112912 cites W2110476762 @default.
• W4200112912 cites W2110871409 @default.
• W4200112912 cites W2125970092 @default.
• W4200112912 cites W2131341361 @default.
• W4200112912 cites W2143902697 @default.
• W4200112912 cites W2153824822 @default.
• W4200112912 cites W2161129289 @default.
• W4200112912 cites W2162691677 @default.
• W4200112912 cites W2166134395 @default.
• W4200112912 cites W2587230422 @default.
• W4200112912 cites W2734453873 @default.
• W4200112912 cites W2755907513 @default.
• W4200112912 cites W2767040033 @default.
• W4200112912 cites W2770896312 @default.
• W4200112912 cites W2886548594 @default.
• W4200112912 cites W2922011152 @default.
• W4200112912 cites W2942118433 @default.
• W4200112912 cites W3083347461 @default.
• W4200112912 doi "https://doi.org/10.1111/vco.12792" @default.
• W4200112912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34907644" @default.
• W4200112912 hasPublicationYear "2022" @default.
• W4200112912 type Work @default.
• W4200112912 citedByCount "0" @default.
• W4200112912 crossrefType "journal-article" @default.
• W4200112912 hasAuthorship W4200112912A5004893002 @default.
• W4200112912 hasAuthorship W4200112912A5034430202 @default.
• W4200112912 hasAuthorship W4200112912A5035318801 @default.
• W4200112912 hasAuthorship W4200112912A5036422444 @default.
• W4200112912 hasAuthorship W4200112912A5038084347 @default.
• W4200112912 hasAuthorship W4200112912A5055544018 @default.
• W4200112912 hasAuthorship W4200112912A5065111139 @default.
• W4200112912 hasAuthorship W4200112912A5086535576 @default.
• W4200112912 hasConcept C142724271 @default.
• W4200112912 hasConcept C1491633281 @default.
• W4200112912 hasConcept C149402561 @default.
• W4200112912 hasConcept C203014093 @default.
• W4200112912 hasConcept C2776310896 @default.
• W4200112912 hasConcept C2777484599 @default.
• W4200112912 hasConcept C2777578932 @default.
• W4200112912 hasConcept C2778256501 @default.
• W4200112912 hasConcept C2779134260 @default.
• W4200112912 hasConcept C2780174970 @default.
• W4200112912 hasConcept C43100952 @default.
• W4200112912 hasConcept C502942594 @default.
• W4200112912 hasConcept C54355233 @default.
• W4200112912 hasConcept C71924100 @default.
• W4200112912 hasConcept C81885089 @default.
• W4200112912 hasConcept C86803240 @default.
• W4200112912 hasConceptScore W4200112912C142724271 @default.
• W4200112912 hasConceptScore W4200112912C1491633281 @default.
• W4200112912 hasConceptScore W4200112912C149402561 @default.
• W4200112912 hasConceptScore W4200112912C203014093 @default.
• W4200112912 hasConceptScore W4200112912C2776310896 @default.
• W4200112912 hasConceptScore W4200112912C2777484599 @default.
• W4200112912 hasConceptScore W4200112912C2777578932 @default.
• W4200112912 hasConceptScore W4200112912C2778256501 @default.
• W4200112912 hasConceptScore W4200112912C2779134260 @default.
• W4200112912 hasConceptScore W4200112912C2780174970 @default.
• W4200112912 hasConceptScore W4200112912C43100952 @default.
• W4200112912 hasConceptScore W4200112912C502942594 @default.

• next