Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200113450> ?p ?o ?g. }
- W4200113450 endingPage "148" @default.
- W4200113450 startingPage "142" @default.
- W4200113450 abstract ": Osteoporosis represents a major public health burden especially considering the aging population worldwide. Treatment modalities for osteoporosis are classified into two categories based on the effect on bone remodelling: anabolic drugs and antiresorptive drugs. Anabolic drugs are preferred as it stimulates new bone formation. Currently, PTH (1-34) is the only peptide-based drug approved as an anabolic agent for the treatment of osteoporosis by both USFDA as well as EMA. However, its non-specific delivery results in prolonged kidney exposure, causing hypercalcemia. Nanotechnology-based drug delivery systems functionalized by conjugating it with homing moieties, such as peptides, offer an advantage of targeted delivery with reduced off-target effects. Here, we propose an innovative and targeted nanovesicle approach to efficiently deliver PTH (1-34) to the bone surface using peptides as a homing moiety. The proposed innovative delivery approach will augment the specific interaction between the drug and bone surface without producing side effects. This will reduce the off-target effects of PTH (1-34), and at the same time, it will also improve the outcome of anabolic therapy. Therefore, we postulate that the proposed innovative drug delivery approach for PTH (1-34) will establish as a promising therapy for osteoporotic patients, specifically in postmenopausal women who are at greater risk of bone fracture." @default.
- W4200113450 created "2021-12-31" @default.
- W4200113450 creator A5006125872 @default.
- W4200113450 creator A5070755475 @default.
- W4200113450 creator A5086789236 @default.
- W4200113450 date "2021-09-01" @default.
- W4200113450 modified "2023-09-27" @default.
- W4200113450 title "Peptide Functionalised Nanocarriers for Bone Specific Delivery of PTH (1-34) in Osteoporosis" @default.
- W4200113450 cites W1495319102 @default.
- W4200113450 cites W1795935625 @default.
- W4200113450 cites W1984408823 @default.
- W4200113450 cites W1984991429 @default.
- W4200113450 cites W1998464768 @default.
- W4200113450 cites W2006804772 @default.
- W4200113450 cites W2030490375 @default.
- W4200113450 cites W2041830938 @default.
- W4200113450 cites W2043007466 @default.
- W4200113450 cites W2044068701 @default.
- W4200113450 cites W2045068208 @default.
- W4200113450 cites W2053699840 @default.
- W4200113450 cites W2063185156 @default.
- W4200113450 cites W2063752793 @default.
- W4200113450 cites W2078958422 @default.
- W4200113450 cites W2086035454 @default.
- W4200113450 cites W2086863316 @default.
- W4200113450 cites W2090423134 @default.
- W4200113450 cites W2090909834 @default.
- W4200113450 cites W2092654589 @default.
- W4200113450 cites W2099028287 @default.
- W4200113450 cites W2137279952 @default.
- W4200113450 cites W2140524010 @default.
- W4200113450 cites W2146732527 @default.
- W4200113450 cites W2148340482 @default.
- W4200113450 cites W2158780196 @default.
- W4200113450 cites W2285090680 @default.
- W4200113450 cites W2379874806 @default.
- W4200113450 cites W2527840829 @default.
- W4200113450 cites W2587417535 @default.
- W4200113450 cites W2610501391 @default.
- W4200113450 cites W2732630371 @default.
- W4200113450 cites W2744710801 @default.
- W4200113450 cites W2773120698 @default.
- W4200113450 cites W2887352219 @default.
- W4200113450 cites W2896289132 @default.
- W4200113450 cites W2906678538 @default.
- W4200113450 cites W2913968625 @default.
- W4200113450 cites W3097231047 @default.
- W4200113450 cites W3130458559 @default.
- W4200113450 cites W4211221406 @default.
- W4200113450 doi "https://doi.org/10.2174/2468187312666211220112324" @default.
- W4200113450 hasPublicationYear "2021" @default.
- W4200113450 type Work @default.
- W4200113450 citedByCount "11" @default.
- W4200113450 countsByYear W42001134502022 @default.
- W4200113450 countsByYear W42001134502023 @default.
- W4200113450 crossrefType "journal-article" @default.
- W4200113450 hasAuthorship W4200113450A5006125872 @default.
- W4200113450 hasAuthorship W4200113450A5070755475 @default.
- W4200113450 hasAuthorship W4200113450A5086789236 @default.
- W4200113450 hasConcept C1008401 @default.
- W4200113450 hasConcept C126322002 @default.
- W4200113450 hasConcept C126511603 @default.
- W4200113450 hasConcept C151872237 @default.
- W4200113450 hasConcept C171250308 @default.
- W4200113450 hasConcept C18150654 @default.
- W4200113450 hasConcept C18903297 @default.
- W4200113450 hasConcept C192562407 @default.
- W4200113450 hasConcept C2776541429 @default.
- W4200113450 hasConcept C2779820397 @default.
- W4200113450 hasConcept C2780035454 @default.
- W4200113450 hasConcept C2910186798 @default.
- W4200113450 hasConcept C71924100 @default.
- W4200113450 hasConcept C86803240 @default.
- W4200113450 hasConcept C98274493 @default.
- W4200113450 hasConceptScore W4200113450C1008401 @default.
- W4200113450 hasConceptScore W4200113450C126322002 @default.
- W4200113450 hasConceptScore W4200113450C126511603 @default.
- W4200113450 hasConceptScore W4200113450C151872237 @default.
- W4200113450 hasConceptScore W4200113450C171250308 @default.
- W4200113450 hasConceptScore W4200113450C18150654 @default.
- W4200113450 hasConceptScore W4200113450C18903297 @default.
- W4200113450 hasConceptScore W4200113450C192562407 @default.
- W4200113450 hasConceptScore W4200113450C2776541429 @default.
- W4200113450 hasConceptScore W4200113450C2779820397 @default.
- W4200113450 hasConceptScore W4200113450C2780035454 @default.
- W4200113450 hasConceptScore W4200113450C2910186798 @default.
- W4200113450 hasConceptScore W4200113450C71924100 @default.
- W4200113450 hasConceptScore W4200113450C86803240 @default.
- W4200113450 hasConceptScore W4200113450C98274493 @default.
- W4200113450 hasIssue "3" @default.
- W4200113450 hasLocation W42001134501 @default.
- W4200113450 hasOpenAccess W4200113450 @default.
- W4200113450 hasPrimaryLocation W42001134501 @default.
- W4200113450 hasRelatedWork W1912498426 @default.
- W4200113450 hasRelatedWork W2088806382 @default.
- W4200113450 hasRelatedWork W2332533961 @default.
- W4200113450 hasRelatedWork W3194583456 @default.
- W4200113450 hasRelatedWork W4200113450 @default.