Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200114528> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W4200114528 abstract "Difficult to test substances, such as poorly soluble, mildly irritating, or Unknown or Variable Composition Complex reaction products or Biological Materials (UVCBs), producing weak or borderline results in the Local Lymph Node Assay (LLNA), face additional challenges in KE-based in in vitro assays that ultimately necessitates data integration in a weight of evidence (WOE) approach to inform skin sensitization potential. Here we present several case studies using a WOE approach with difficult to test substances and highlight the utility of Toxicological Prioritization Index (ToxPi) as a comparative data visualization and integration tool to compare biological activity as it relates to skin sensitization. The four case study test substances represent two poorly soluble substances, tetrakis (2-ethylbutyl) orthosilicate and decyl palmitate, and two UVCB substances, alkylated anisole and hydrazinecarboximidamide, 2-[(2-hydroxyphenyl)methylene]-, reaction products with 2 undecanone. Data from in vivo and in vitro assays representing multiple key events within the skin sensitization adverse outcome pathway (protein binding, keratinocyte/dendritic cell activation and t-cell proliferation) were gathered from publicly available sources or specifically generated. Incorporating the data on our case study test substances as well as on chemicals of a known sensitization class (sensitizer, irritating non-sensitizer, and non-sensitizer) into ToxPi revealed biological activity profiles which could be grouped using unsupervised hierarchical clustering to inform skin sensitization potential. Using this method, the biological activity profiles for three of the case study test substances concluded to have a lack of skin sensitization potential by traditional WOE were most consistent with non-sensitizing chemicals, whereas the prediction was not as definitive for a positive case study test substance. Visualizing the WOE using bioactivity profiles can provide further support for individual chemical WOE predictions in certain circumstances but is unlikely to replace WOE as a stand-alone prediction due to limitations of the method such as the impact of missing data points." @default.
- W4200114528 created "2021-12-31" @default.
- W4200114528 creator A5038092041 @default.
- W4200114528 creator A5057477347 @default.
- W4200114528 creator A5063885734 @default.
- W4200114528 creator A5067786023 @default.
- W4200114528 date "2021-11-23" @default.
- W4200114528 modified "2023-09-27" @default.
- W4200114528 title "Challenges in integrating skin sensitization data for assessment of difficult to test substances" @default.
- W4200114528 doi "https://doi.org/10.31219/osf.io/purz6" @default.
- W4200114528 hasPublicationYear "2021" @default.
- W4200114528 type Work @default.
- W4200114528 citedByCount "0" @default.
- W4200114528 crossrefType "posted-content" @default.
- W4200114528 hasAuthorship W4200114528A5038092041 @default.
- W4200114528 hasAuthorship W4200114528A5057477347 @default.
- W4200114528 hasAuthorship W4200114528A5063885734 @default.
- W4200114528 hasAuthorship W4200114528A5067786023 @default.
- W4200114528 hasBestOaLocation W42001145281 @default.
- W4200114528 hasConcept C185592680 @default.
- W4200114528 hasConcept C203014093 @default.
- W4200114528 hasConcept C2776217527 @default.
- W4200114528 hasConcept C2780614586 @default.
- W4200114528 hasConcept C3018346242 @default.
- W4200114528 hasConcept C33070731 @default.
- W4200114528 hasConcept C86803240 @default.
- W4200114528 hasConcept C98274493 @default.
- W4200114528 hasConceptScore W4200114528C185592680 @default.
- W4200114528 hasConceptScore W4200114528C203014093 @default.
- W4200114528 hasConceptScore W4200114528C2776217527 @default.
- W4200114528 hasConceptScore W4200114528C2780614586 @default.
- W4200114528 hasConceptScore W4200114528C3018346242 @default.
- W4200114528 hasConceptScore W4200114528C33070731 @default.
- W4200114528 hasConceptScore W4200114528C86803240 @default.
- W4200114528 hasConceptScore W4200114528C98274493 @default.
- W4200114528 hasLocation W42001145281 @default.
- W4200114528 hasOpenAccess W4200114528 @default.
- W4200114528 hasPrimaryLocation W42001145281 @default.
- W4200114528 hasRelatedWork W2034475424 @default.
- W4200114528 hasRelatedWork W2101239849 @default.
- W4200114528 hasRelatedWork W2810914985 @default.
- W4200114528 hasRelatedWork W2947033007 @default.
- W4200114528 hasRelatedWork W2949693725 @default.
- W4200114528 hasRelatedWork W2959547489 @default.
- W4200114528 hasRelatedWork W4210910465 @default.
- W4200114528 hasRelatedWork W4220812658 @default.
- W4200114528 hasRelatedWork W4248223904 @default.
- W4200114528 hasRelatedWork W83380756 @default.
- W4200114528 isParatext "false" @default.
- W4200114528 isRetracted "false" @default.
- W4200114528 workType "article" @default.