FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200115131> ?p ?o ?g. }

• W4200115131 endingPage "285" @default.
• W4200115131 startingPage "269" @default.
• W4200115131 abstract "Lung cancer is one of the most common causes of cancer-associated mortality worldwide. Upregulation of kinesin family member 15 (KIF15) expression has been observed in non-small cell lung cancer (NSCLC), and high expression levels of KIF15 are associated with a poor prognosis in patients with NSCLC. However, to the best of our knowledge, the mechanisms by which KIF15 regulates apoptosis, migration and invasion in NSCLC remain unclear.Cell Counting Kit-8, flow cytometry and Transwell assays were performed to determine the proliferation, apoptosis and invasion of NSCLC cells, respectively. In addition, western blotting was used to detect the levels of phosphorylated (p-)c-Raf, p-ERK and p-MEK in NSCLC cells.Downregulation of KIF15 expression markedly inhibited the proliferation, migration and invasion of NSCLC cells through mediation of MMP2 and MMP9. In addition, downregulation of KIF15 markedly induced apoptosis and cell cycle arrest in NSCLC cells through regulation of active caspase 3, p27 Kip1 and cyclin D1. Furthermore, KIF15 knockdown notably decreased the levels of activating transcription factor 2, p-c-Raf, p-ERK and p-MEK in A549 and NCI-H460 cells. Finally, KIF15 knockdown notably inhibited the tumor growth of NSCLC in vivo.In conclusion, the present study indicated that downregulation of KIF15 expression was able to inhibit the tumorigenesis of NSCLC by inactivating Raf/MEK/ERK signaling. These findings may help improve the diagnosis and treatment of NSCLC." @default.
• W4200115131 created "2021-12-31" @default.
• W4200115131 creator A5000030352 @default.
• W4200115131 creator A5011877804 @default.
• W4200115131 creator A5014859545 @default.
• W4200115131 creator A5016894561 @default.
• W4200115131 creator A5023519598 @default.
• W4200115131 creator A5049686066 @default.
• W4200115131 creator A5080058462 @default.
• W4200115131 date "2022-03-01" @default.
• W4200115131 modified "2023-09-28" @default.
• W4200115131 title "Downregulation of KIF15 inhibits the tumorigenesis of non-small-cell lung cancer via inactivating Raf/MEK/ERK signaling." @default.
• W4200115131 cites W1966680971 @default.
• W4200115131 cites W1972068350 @default.
• W4200115131 cites W2008046168 @default.
• W4200115131 cites W2042906030 @default.
• W4200115131 cites W2081940894 @default.
• W4200115131 cites W2094009347 @default.
• W4200115131 cites W2095031931 @default.
• W4200115131 cites W2107277218 @default.
• W4200115131 cites W2113067498 @default.
• W4200115131 cites W2152429112 @default.
• W4200115131 cites W2166227344 @default.
• W4200115131 cites W2230320310 @default.
• W4200115131 cites W2405784970 @default.
• W4200115131 cites W2515418207 @default.
• W4200115131 cites W2587125658 @default.
• W4200115131 cites W2591751612 @default.
• W4200115131 cites W2607129810 @default.
• W4200115131 cites W2624496214 @default.
• W4200115131 cites W2748992739 @default.
• W4200115131 cites W2752625590 @default.
• W4200115131 cites W2768068181 @default.
• W4200115131 cites W2773200589 @default.
• W4200115131 cites W2793731902 @default.
• W4200115131 cites W2896818550 @default.
• W4200115131 cites W2901854750 @default.
• W4200115131 cites W2906940574 @default.
• W4200115131 cites W2908337758 @default.
• W4200115131 cites W2915154871 @default.
• W4200115131 cites W2916394440 @default.
• W4200115131 cites W2922139167 @default.
• W4200115131 cites W2955176617 @default.
• W4200115131 cites W2955347655 @default.
• W4200115131 cites W2962062722 @default.
• W4200115131 cites W2980335776 @default.
• W4200115131 cites W3000124456 @default.
• W4200115131 cites W3006930497 @default.
• W4200115131 cites W3008111271 @default.
• W4200115131 cites W3014217474 @default.
• W4200115131 cites W3015105073 @default.
• W4200115131 cites W3018592955 @default.
• W4200115131 cites W3019137889 @default.
• W4200115131 cites W3019810379 @default.
• W4200115131 cites W3021050361 @default.
• W4200115131 cites W3035781992 @default.
• W4200115131 cites W3043921850 @default.
• W4200115131 cites W3120246130 @default.
• W4200115131 cites W3122648990 @default.
• W4200115131 cites W3128482627 @default.
• W4200115131 cites W3132457317 @default.
• W4200115131 cites W3135468693 @default.
• W4200115131 cites W3135736296 @default.
• W4200115131 cites W3157708182 @default.
• W4200115131 cites W1964184380 @default.
• W4200115131 doi "https://doi.org/10.14670/hh-18-408" @default.
• W4200115131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34908156" @default.
• W4200115131 hasPublicationYear "2022" @default.
• W4200115131 type Work @default.
• W4200115131 citedByCount "3" @default.
• W4200115131 countsByYear W42001151312023 @default.
• W4200115131 crossrefType "journal-article" @default.
• W4200115131 hasAuthorship W4200115131A5000030352 @default.
• W4200115131 hasAuthorship W4200115131A5011877804 @default.
• W4200115131 hasAuthorship W4200115131A5014859545 @default.
• W4200115131 hasAuthorship W4200115131A5016894561 @default.
• W4200115131 hasAuthorship W4200115131A5023519598 @default.
• W4200115131 hasAuthorship W4200115131A5049686066 @default.
• W4200115131 hasAuthorship W4200115131A5080058462 @default.
• W4200115131 hasConcept C104317684 @default.
• W4200115131 hasConcept C121608353 @default.
• W4200115131 hasConcept C127561419 @default.
• W4200115131 hasConcept C173396325 @default.
• W4200115131 hasConcept C185592680 @default.
• W4200115131 hasConcept C190283241 @default.
• W4200115131 hasConcept C29537977 @default.
• W4200115131 hasConcept C502942594 @default.
• W4200115131 hasConcept C54355233 @default.
• W4200115131 hasConcept C55493867 @default.
• W4200115131 hasConcept C555283112 @default.
• W4200115131 hasConcept C57074206 @default.
• W4200115131 hasConcept C62112901 @default.
• W4200115131 hasConcept C62478195 @default.
• W4200115131 hasConcept C86803240 @default.
• W4200115131 hasConcept C95444343 @default.
• W4200115131 hasConceptScore W4200115131C104317684 @default.
• W4200115131 hasConceptScore W4200115131C121608353 @default.
• W4200115131 hasConceptScore W4200115131C127561419 @default.

• next