Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200117625> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W4200117625 abstract "New brain atlases with high spatial resolution and whole-brain coverage have rapidly advanced our knowledge of the brain's neural architecture, including the systematic variation of excitatory and inhibitory cell densities across the mammalian cortex. But understanding how the brain's microscale physiology shapes brain dynamics at the macroscale has remained a challenge. While physiologically based mathematical models of brain dynamics are well placed to bridge this explanatory gap, their complexity can form a barrier to providing clear mechanistic interpretation of the dynamics they generate. In this work we develop a neural-mass model of the mouse cortex and show how bifurcation diagrams, which capture local dynamical responses to inputs and their variation across brain regions, can be used to understand the resulting whole-brain dynamics. We show that strong fits to resting-state functional magnetic resonance imaging (fMRI) data can be found in surprisingly simple dynamical regimes (including where all brain regions are confined to a stable fixed point) where regions are able to respond strongly to variations in their inputs, consistent with direct structural connections providing a strong constraint on functional connectivity in the anesthetized mouse. We also use bifurcation diagrams to show how perturbations to local excitatory and inhibitory coupling strengths across the cortex, constrained by cell-density data, provide spatially dependent constraints on resulting cortical activity, and support a greater diversity of coincident dynamical regimes. Our work illustrates methods for visualizing and interpreting model performance in terms of underlying dynamical mechanisms, an approach that is crucial for building explanatory and physiologically grounded models of the dynamical principles that underpin large-scale brain activity." @default.
- W4200117625 created "2021-12-31" @default.
- W4200117625 creator A5020266584 @default.
- W4200117625 creator A5025623322 @default.
- W4200117625 creator A5058499321 @default.
- W4200117625 creator A5076633128 @default.
- W4200117625 creator A5091269081 @default.
- W4200117625 date "2021-12-23" @default.
- W4200117625 modified "2023-10-17" @default.
- W4200117625 title "Extracting dynamical understanding from neural-mass models of mouse cortex" @default.
- W4200117625 doi "https://doi.org/10.1101/2021.12.22.473927" @default.
- W4200117625 hasPublicationYear "2021" @default.
- W4200117625 type Work @default.
- W4200117625 citedByCount "0" @default.
- W4200117625 crossrefType "posted-content" @default.
- W4200117625 hasAuthorship W4200117625A5020266584 @default.
- W4200117625 hasAuthorship W4200117625A5025623322 @default.
- W4200117625 hasAuthorship W4200117625A5058499321 @default.
- W4200117625 hasAuthorship W4200117625A5076633128 @default.
- W4200117625 hasAuthorship W4200117625A5091269081 @default.
- W4200117625 hasBestOaLocation W42001176251 @default.
- W4200117625 hasConcept C121332964 @default.
- W4200117625 hasConcept C154945302 @default.
- W4200117625 hasConcept C169760540 @default.
- W4200117625 hasConcept C186060115 @default.
- W4200117625 hasConcept C2779345533 @default.
- W4200117625 hasConcept C41008148 @default.
- W4200117625 hasConcept C62520636 @default.
- W4200117625 hasConcept C79379906 @default.
- W4200117625 hasConcept C86803240 @default.
- W4200117625 hasConceptScore W4200117625C121332964 @default.
- W4200117625 hasConceptScore W4200117625C154945302 @default.
- W4200117625 hasConceptScore W4200117625C169760540 @default.
- W4200117625 hasConceptScore W4200117625C186060115 @default.
- W4200117625 hasConceptScore W4200117625C2779345533 @default.
- W4200117625 hasConceptScore W4200117625C41008148 @default.
- W4200117625 hasConceptScore W4200117625C62520636 @default.
- W4200117625 hasConceptScore W4200117625C79379906 @default.
- W4200117625 hasConceptScore W4200117625C86803240 @default.
- W4200117625 hasLocation W42001176251 @default.
- W4200117625 hasLocation W42001176252 @default.
- W4200117625 hasOpenAccess W4200117625 @default.
- W4200117625 hasPrimaryLocation W42001176251 @default.
- W4200117625 hasRelatedWork W1989867524 @default.
- W4200117625 hasRelatedWork W2072521404 @default.
- W4200117625 hasRelatedWork W2100171700 @default.
- W4200117625 hasRelatedWork W2113455284 @default.
- W4200117625 hasRelatedWork W2134128872 @default.
- W4200117625 hasRelatedWork W2755568542 @default.
- W4200117625 hasRelatedWork W2773562874 @default.
- W4200117625 hasRelatedWork W2892615779 @default.
- W4200117625 hasRelatedWork W3015888538 @default.
- W4200117625 hasRelatedWork W2188245770 @default.
- W4200117625 isParatext "false" @default.
- W4200117625 isRetracted "false" @default.
- W4200117625 workType "article" @default.