Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200119953> ?p ?o ?g. }
- W4200119953 abstract "Following a cerebral ischemic event, substantial alterations in both cellular and molecular activities occur due to ischemia-induced cerebral pathology. Mounting evidence indicates that the robust recruitment of immune cells plays a central role in the acute stage of stroke. Infiltrating peripheral immune cells and resident microglia mediate neuronal cell death and blood-brain barrier disruption by releasing inflammation-associated molecules. Nevertheless, profound immunological effects in the context of the subacute and chronic recovery phase of stroke have received little attention. Early attempts to curtail the infiltration of immune cells were effective in mitigating brain injury in experimental stroke studies but failed to exert beneficial effects in clinical trials. Neural tissue damage repair processes include angiogenesis, neurogenesis, and synaptic remodeling, etc. Post-stroke inflammatory cells can adopt divergent phenotypes that influence the aforementioned biological processes in both endothelial and neural stem cells by either alleviating acute inflammatory responses or secreting a variety of growth factors, which are substantially involved in the process of angiogenesis and neurogenesis. To better understand the multiple roles of immune cells in neural tissue repair processes post stroke, we review what is known and unknown regarding the role of immune cells in angiogenesis, neurogenesis, and neuronal remodeling. A comprehensive understanding of these inflammatory mechanisms may help identify potential targets for the development of novel immunoregulatory therapeutic strategies that ameliorate complications and improve functional rehabilitation after stroke." @default.
- W4200119953 created "2021-12-31" @default.
- W4200119953 creator A5021483019 @default.
- W4200119953 creator A5023325380 @default.
- W4200119953 creator A5026922421 @default.
- W4200119953 creator A5044246698 @default.
- W4200119953 creator A5076116273 @default.
- W4200119953 date "2021-12-16" @default.
- W4200119953 modified "2023-10-16" @default.
- W4200119953 title "The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown" @default.
- W4200119953 cites W1487852103 @default.
- W4200119953 cites W1518095394 @default.
- W4200119953 cites W1589879174 @default.
- W4200119953 cites W1600153751 @default.
- W4200119953 cites W1657402881 @default.
- W4200119953 cites W1869691464 @default.
- W4200119953 cites W1964730250 @default.
- W4200119953 cites W1966092653 @default.
- W4200119953 cites W1967076681 @default.
- W4200119953 cites W1972442533 @default.
- W4200119953 cites W1981352649 @default.
- W4200119953 cites W1984011020 @default.
- W4200119953 cites W1986677588 @default.
- W4200119953 cites W1995654132 @default.
- W4200119953 cites W1996024251 @default.
- W4200119953 cites W1998670209 @default.
- W4200119953 cites W1999235115 @default.
- W4200119953 cites W2002413415 @default.
- W4200119953 cites W2005215351 @default.
- W4200119953 cites W2008479676 @default.
- W4200119953 cites W2010922413 @default.
- W4200119953 cites W2014604252 @default.
- W4200119953 cites W2021676903 @default.
- W4200119953 cites W2024418424 @default.
- W4200119953 cites W2029473544 @default.
- W4200119953 cites W2030851291 @default.
- W4200119953 cites W2031055913 @default.
- W4200119953 cites W2032196626 @default.
- W4200119953 cites W2032348735 @default.
- W4200119953 cites W2034279215 @default.
- W4200119953 cites W2034861293 @default.
- W4200119953 cites W2035221144 @default.
- W4200119953 cites W2037328262 @default.
- W4200119953 cites W2037788197 @default.
- W4200119953 cites W2040579356 @default.
- W4200119953 cites W2044964887 @default.
- W4200119953 cites W2047153310 @default.
- W4200119953 cites W2047718958 @default.
- W4200119953 cites W2048953929 @default.
- W4200119953 cites W2050070550 @default.
- W4200119953 cites W2053298425 @default.
- W4200119953 cites W2056973477 @default.
- W4200119953 cites W2057422278 @default.
- W4200119953 cites W2064959778 @default.
- W4200119953 cites W2065442531 @default.
- W4200119953 cites W2067028731 @default.
- W4200119953 cites W2071002641 @default.
- W4200119953 cites W2071205488 @default.
- W4200119953 cites W2073472691 @default.
- W4200119953 cites W2076918465 @default.
- W4200119953 cites W2077439063 @default.
- W4200119953 cites W2077720998 @default.
- W4200119953 cites W2079272687 @default.
- W4200119953 cites W2080931209 @default.
- W4200119953 cites W2083796876 @default.
- W4200119953 cites W2084301200 @default.
- W4200119953 cites W2084977288 @default.
- W4200119953 cites W2086680310 @default.
- W4200119953 cites W2089108509 @default.
- W4200119953 cites W2090836465 @default.
- W4200119953 cites W2091646946 @default.
- W4200119953 cites W2091680215 @default.
- W4200119953 cites W2091740143 @default.
- W4200119953 cites W2095315362 @default.
- W4200119953 cites W2103327450 @default.
- W4200119953 cites W2110567194 @default.
- W4200119953 cites W2112094579 @default.
- W4200119953 cites W2115659532 @default.
- W4200119953 cites W2116844587 @default.
- W4200119953 cites W2118200665 @default.
- W4200119953 cites W2125382661 @default.
- W4200119953 cites W2128944765 @default.
- W4200119953 cites W2133397650 @default.
- W4200119953 cites W2144890529 @default.
- W4200119953 cites W2151400960 @default.
- W4200119953 cites W2151551770 @default.
- W4200119953 cites W2157668990 @default.
- W4200119953 cites W2159103481 @default.
- W4200119953 cites W2159560463 @default.
- W4200119953 cites W2161607126 @default.
- W4200119953 cites W2167101174 @default.
- W4200119953 cites W2168176302 @default.
- W4200119953 cites W2168203604 @default.
- W4200119953 cites W2168476587 @default.
- W4200119953 cites W2170899083 @default.
- W4200119953 cites W2172018237 @default.
- W4200119953 cites W2180372668 @default.
- W4200119953 cites W2196906371 @default.
- W4200119953 cites W2216083821 @default.
- W4200119953 cites W2253366929 @default.