Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200122652> ?p ?o ?g. }
- W4200122652 endingPage "1988" @default.
- W4200122652 startingPage "1988" @default.
- W4200122652 abstract "Glioblastoma remains the deadliest form of brain cancer, largely because these tumors become resistant to standard of care treatment with radiation and chemotherapy. Intracellular production of reactive oxygen species (ROS) is necessary for chemo- and radiotherapy-induced cytotoxicity. Here, we assessed whether antioxidant catalase (CAT) affects glioma cell sensitivity to temozolomide and radiation. Using The Cancer Genome Atlas database, we found that CAT mRNA expression is upregulated in glioma tumor tissue compared with non-tumor tissue, and the level of expression negatively correlates with the overall survival of patients with high-grade glioma. In U251 glioma cells, CAT overexpression substantially decreased the basal level of hydrogen peroxide, enhanced anchorage-independent cell growth, and facilitated resistance to the chemotherapeutic drug temozolomide and ionizing radiation. Importantly, pharmacological inhibition of CAT activity reduced the proliferation of glioma cells isolated from patient biopsy samples. Moreover, U251 cells overexpressing CAT formed neurospheres in neurobasal medium, whereas control cells did not, suggesting that the radio- and chemoresistance conferred by CAT may be due in part to the enrichment of glioma stem cell populations. Finally, CAT overexpression significantly decreased survival in an orthotopic mouse model of glioma. These results demonstrate that CAT regulates chemo- and radioresistance in human glioma." @default.
- W4200122652 created "2021-12-31" @default.
- W4200122652 creator A5021743376 @default.
- W4200122652 creator A5022997720 @default.
- W4200122652 creator A5034153294 @default.
- W4200122652 creator A5046116573 @default.
- W4200122652 creator A5047280804 @default.
- W4200122652 creator A5049837018 @default.
- W4200122652 creator A5074549728 @default.
- W4200122652 creator A5086151080 @default.
- W4200122652 date "2021-12-14" @default.
- W4200122652 modified "2023-09-26" @default.
- W4200122652 title "Catalase Overexpression Drives an Aggressive Phenotype in Glioblastoma" @default.
- W4200122652 cites W1497326317 @default.
- W4200122652 cites W1541324451 @default.
- W4200122652 cites W1963510913 @default.
- W4200122652 cites W1967229412 @default.
- W4200122652 cites W1970972818 @default.
- W4200122652 cites W1975625671 @default.
- W4200122652 cites W1976599392 @default.
- W4200122652 cites W1980387702 @default.
- W4200122652 cites W1985249209 @default.
- W4200122652 cites W1991523385 @default.
- W4200122652 cites W1995199032 @default.
- W4200122652 cites W2000647702 @default.
- W4200122652 cites W2025141680 @default.
- W4200122652 cites W2035979637 @default.
- W4200122652 cites W2036974544 @default.
- W4200122652 cites W2041442332 @default.
- W4200122652 cites W2067819328 @default.
- W4200122652 cites W2076104235 @default.
- W4200122652 cites W2078090935 @default.
- W4200122652 cites W2081260625 @default.
- W4200122652 cites W2089210293 @default.
- W4200122652 cites W2096287682 @default.
- W4200122652 cites W2105100844 @default.
- W4200122652 cites W2105951762 @default.
- W4200122652 cites W2109395671 @default.
- W4200122652 cites W2113710155 @default.
- W4200122652 cites W2131487381 @default.
- W4200122652 cites W2131981377 @default.
- W4200122652 cites W2132834292 @default.
- W4200122652 cites W214449776 @default.
- W4200122652 cites W2167241157 @default.
- W4200122652 cites W2169768109 @default.
- W4200122652 cites W2316210347 @default.
- W4200122652 cites W2319302105 @default.
- W4200122652 cites W2417535489 @default.
- W4200122652 cites W2519786994 @default.
- W4200122652 cites W2524459993 @default.
- W4200122652 cites W2554863679 @default.
- W4200122652 cites W2586020508 @default.
- W4200122652 cites W2587964111 @default.
- W4200122652 cites W2606580606 @default.
- W4200122652 cites W2790757017 @default.
- W4200122652 cites W2792235941 @default.
- W4200122652 cites W2906120852 @default.
- W4200122652 cites W2913964857 @default.
- W4200122652 cites W2950040412 @default.
- W4200122652 cites W2981082293 @default.
- W4200122652 cites W3003357115 @default.
- W4200122652 cites W3005689864 @default.
- W4200122652 cites W3042360629 @default.
- W4200122652 cites W3092206934 @default.
- W4200122652 cites W3124271137 @default.
- W4200122652 cites W3134598995 @default.
- W4200122652 doi "https://doi.org/10.3390/antiox10121988" @default.
- W4200122652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34943091" @default.
- W4200122652 hasPublicationYear "2021" @default.
- W4200122652 type Work @default.
- W4200122652 citedByCount "9" @default.
- W4200122652 countsByYear W42001226522022 @default.
- W4200122652 countsByYear W42001226522023 @default.
- W4200122652 crossrefType "journal-article" @default.
- W4200122652 hasAuthorship W4200122652A5021743376 @default.
- W4200122652 hasAuthorship W4200122652A5022997720 @default.
- W4200122652 hasAuthorship W4200122652A5034153294 @default.
- W4200122652 hasAuthorship W4200122652A5046116573 @default.
- W4200122652 hasAuthorship W4200122652A5047280804 @default.
- W4200122652 hasAuthorship W4200122652A5049837018 @default.
- W4200122652 hasAuthorship W4200122652A5074549728 @default.
- W4200122652 hasAuthorship W4200122652A5086151080 @default.
- W4200122652 hasBestOaLocation W42001226521 @default.
- W4200122652 hasConcept C134018914 @default.
- W4200122652 hasConcept C2776151105 @default.
- W4200122652 hasConcept C2777389519 @default.
- W4200122652 hasConcept C2777658100 @default.
- W4200122652 hasConcept C2778227246 @default.
- W4200122652 hasConcept C2778979269 @default.
- W4200122652 hasConcept C2780964509 @default.
- W4200122652 hasConcept C502942594 @default.
- W4200122652 hasConcept C54355233 @default.
- W4200122652 hasConcept C58962609 @default.
- W4200122652 hasConcept C81885089 @default.
- W4200122652 hasConcept C86803240 @default.
- W4200122652 hasConceptScore W4200122652C134018914 @default.
- W4200122652 hasConceptScore W4200122652C2776151105 @default.
- W4200122652 hasConceptScore W4200122652C2777389519 @default.