FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200126452> ?p ?o ?g. }

• W4200126452 endingPage "190" @default.
• W4200126452 startingPage "176" @default.
• W4200126452 abstract "Background: Among the frequent daily challenges in the practice of gynecology are abnormal uterine bleeding (AUB) beside the distinction of fundamental endometrial lesions that stand behind it .Ki67 is among the excellent markers as the higher proliferation rate is one of the features of cancer cells. Aim: This study aims to clarify the expression of Ki67 in the endometrium of women suffering from abnormal uterine bleeding in Nineveh Province and to correlate its expression with the histological picture. Subjects, Materials, and Methods: This is a case series study that was enrolled analysis of data (retrospectively and prospectively) of 51 females who were presented with history of abnormal uterine bleeding and they were underwent an elective D&C and or hysterectomy after admission in several Hospitals, in Nineveh Province, Northern Iraq from 1st January, 2020 to 30th December, 2020. The selected paraffin blocks (n-=51) were cut into 3-4 micrometers thick sections and mounted on poly-L-lysine glass slides for immunohistochemical staining with using of positive and negative control sections at Unit of Immunohistochemistry in Vin Hospital -Duhok-North of Iraq. Staining was performe using the optimized protocol recommended by the International Ki67 in Breast Cancer Working Group together with Dako Autostainer according to manufacturer instructions. Results: This work revealed that 23(45%)out of 51 cases were aged >50 years.The highest mean of percentage of Ki67expression was in sections of proliferative endometrium.In fact, sections of 3/7 of cases which were exhibited a percentage of Ki67 expression from 76% to 100% aged >50 years, while sections of 3/7 of cases of menopause women showed percentage of Ki67 expression from 26% to 75 %. Further, 12 cases out of 17 showed an intensity of staining score of 2 were aged ˂50 years, while 3 out of 5 cases (which revealed an intensity of 3 ) were aged < 50 years. Five cases out of 17 which showed an intensity of staining score of 2 were aged >50 years, while 2 out of 5 cases which exhibited an intensity score of 3 were aged > 50 years. The current study showed that 11/16 cases of benign conditions presented with percentage of Ki67 expression of less than 25%,while 14/15 cases of endometrial hyperplasia presented with Ki67 expression of <25%.In contrary, 8 cases out of 20 ofcases of endometrial adenocarcinomashowedKi67 expression of >25%. Further,the intensity ofKi67 immunostaining of more than 2 was shown in 4 cases of endometrial adenocarcinoma. Regarding cases of endometrial hyperplasia, the current work revealed that 7 cases (46%) out of 15 cases were aged more than 50 years. About 4 cases (26%) of them are of atypical type withno significant differences between the percentage and intensity of Ki67 expression in cases of endometrial hyperplasia. In fact, 15 cases (75%) of endometrial adenocarcinoma were aged more than 50 years. Four (20%) of them were of grade 3, while six cases (30%) of them were of grade 2.According to the grade of endometrial adenocarcinoma, sections of 2 out of 5 cases of grade one (well differentiation) endometrial adenocarcinoma showed the percentage of Ki67 expression of more than 15%, while 5 out of 10 cases of grade 2 (Moderately differentiation) endometrial adenocarcinoma showed the percentage of Ki67 expression of more than 15%. Finally, 3 out of 5 cases of grade 3 (poorly differentiation) endometrial adenocarcinoma showed the percentage of Ki67 expression of more than 15%. About 5 cases out of 16 with Ki67 expression of more than 25%.Finally, 8 cases out of 20 cases of endometrial adenocarcinoma showed the Ki67 expression of more than 25%. Conclusion: Analysis of immunohistochemical expression of Ki67 in sections of women presented with AUB revealed that there is a relation with the age of patients. A significant association between expression of the Ki67 and poor tumor characteristics was conclude. Significant differences was shown between the expression of the Ki67 in sections of proliferative phase and those of endometrial hyperplasia ,while significant differences was found between the expression of the Ki67 in sections of endometrial hyperplasia and those of endometrial carcinoma. Using of Ki67 as diagnostic and prognostic tool in endometrial carcinoma may be conclude." @default.
• W4200126452 created "2021-12-31" @default.
• W4200126452 creator A5044987712 @default.
• W4200126452 creator A5060367450 @default.
• W4200126452 creator A5075952823 @default.
• W4200126452 date "2021-12-01" @default.
• W4200126452 modified "2023-10-18" @default.
• W4200126452 title "Clarification of Ki67 Expression in Association with the Histological Picture of Endometrium in Cases with Abnormal Uterine Bleeding in Nineveh Province" @default.
• W4200126452 doi "https://doi.org/10.33899/mmed.2021.131088.1106" @default.
• W4200126452 hasPublicationYear "2021" @default.
• W4200126452 type Work @default.
• W4200126452 citedByCount "0" @default.
• W4200126452 crossrefType "journal-article" @default.
• W4200126452 hasAuthorship W4200126452A5044987712 @default.
• W4200126452 hasAuthorship W4200126452A5060367450 @default.
• W4200126452 hasAuthorship W4200126452A5075952823 @default.
• W4200126452 hasBestOaLocation W42001264521 @default.
• W4200126452 hasConcept C121608353 @default.
• W4200126452 hasConcept C126322002 @default.
• W4200126452 hasConcept C131872663 @default.
• W4200126452 hasConcept C142724271 @default.
• W4200126452 hasConcept C204232928 @default.
• W4200126452 hasConcept C2777088508 @default.
• W4200126452 hasConcept C2779494336 @default.
• W4200126452 hasConcept C2779742232 @default.
• W4200126452 hasConcept C29456083 @default.
• W4200126452 hasConcept C2993353421 @default.
• W4200126452 hasConcept C71924100 @default.
• W4200126452 hasConceptScore W4200126452C121608353 @default.
• W4200126452 hasConceptScore W4200126452C126322002 @default.
• W4200126452 hasConceptScore W4200126452C131872663 @default.
• W4200126452 hasConceptScore W4200126452C142724271 @default.
• W4200126452 hasConceptScore W4200126452C204232928 @default.
• W4200126452 hasConceptScore W4200126452C2777088508 @default.
• W4200126452 hasConceptScore W4200126452C2779494336 @default.
• W4200126452 hasConceptScore W4200126452C2779742232 @default.
• W4200126452 hasConceptScore W4200126452C29456083 @default.
• W4200126452 hasConceptScore W4200126452C2993353421 @default.
• W4200126452 hasConceptScore W4200126452C71924100 @default.
• W4200126452 hasIssue "2" @default.
• W4200126452 hasLocation W42001264521 @default.
• W4200126452 hasOpenAccess W4200126452 @default.
• W4200126452 hasPrimaryLocation W42001264521 @default.
• W4200126452 hasRelatedWork W1968084067 @default.
• W4200126452 hasRelatedWork W2058489011 @default.
• W4200126452 hasRelatedWork W2085301701 @default.
• W4200126452 hasRelatedWork W2392009179 @default.
• W4200126452 hasRelatedWork W2495848194 @default.
• W4200126452 hasRelatedWork W2734526255 @default.
• W4200126452 hasRelatedWork W3011096206 @default.
• W4200126452 hasRelatedWork W4285198341 @default.
• W4200126452 hasRelatedWork W7717921 @default.
• W4200126452 hasRelatedWork W95134475 @default.
• W4200126452 hasVolume "43" @default.
• W4200126452 isParatext "false" @default.
• W4200126452 isRetracted "false" @default.
• W4200126452 workType "article" @default.