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- W4200133056 abstract "Antitumor immunosurveillance is triggered by immune cell recognition of characteristic biochemical signals on the surfaces of cancer cells. Recent data suggest that the mechanical properties of cancer cells influence the strength of these signals, with physically harder target cells (more rigid) eliciting better, faster, and stronger cytotoxic responses against metastasis. Using analogies to a certain electronic music duo, we argue that the biophysical properties of cancer cells and their environment can adjust the volume and tone of the antitumor immune response. We also consider the potential influence of biomechanics-based immunosurveillance in disease progression and posit that targeting the biophysical properties of cancer cells in concert with their biochemical features could increase the efficacy of immunotherapy." @default.
- W4200133056 created "2021-12-31" @default.
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- W4200133056 date "2022-02-01" @default.
- W4200133056 modified "2023-10-14" @default.
- W4200133056 title "Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert" @default.
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- W4200133056 doi "https://doi.org/10.1016/j.it.2021.12.003" @default.
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