Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200133119> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4200133119 endingPage "776" @default.
- W4200133119 startingPage "768" @default.
- W4200133119 abstract "The Federal project “Cancer Control” was launched in 2019. Its main objective is to reduce mortality from malignant neoplasms in Russia.
 The main goal of this research is to develop a methodology for assessment of innovative drugs treatment impact on reducing mortality from neoplasms (including malignant) and testing it in the case of some novel drugs.
 Materials and methods. Firstly, we assessed the number of patients, who annually can start a novel drug treatment. Afterwards we estimated the number of deaths, which could be avoided due to the efficacy differences between innovative drugs compared to the standard of care in terms of overall survival. Obtained results were than correlated to the reduction in malignant mortality ratio needed to achieve annually (comparing to the basis 2020). For the approbation of the model, we chose durvalumab, osimertinib and olaparib, which are indicated for lung and ovarian cancer treatment.
 Results. Annually 6 746 patients can start the treatment: 2 391 with durvalumab, 2 334 with osimertinib, 2 021 with olaparib. In the 2021-2023 frame durvalumab treatment can help to avoid 779 deaths, osimertinib treatment can help to avoid 723 deaths, olaparib treatment can help to avoid 679 deaths (totally 10,8% of reduction in deaths needed to achieve 2021-2023 goals).
 Conclusion. Novel antineoplastic drugs treatment leads to a quantifiable reduction in mortality from malignant neoplasms in Russia." @default.
- W4200133119 created "2021-12-31" @default.
- W4200133119 creator A5033003782 @default.
- W4200133119 creator A5060075550 @default.
- W4200133119 creator A5063459103 @default.
- W4200133119 creator A5065893772 @default.
- W4200133119 date "2021-12-30" @default.
- W4200133119 modified "2023-10-01" @default.
- W4200133119 title "Analysis of novel antineoplastic drugs treatment impact on the federal project «cancer control» goals achievement" @default.
- W4200133119 doi "https://doi.org/10.37469/0507-3758-2021-67-6-768-776" @default.
- W4200133119 hasPublicationYear "2021" @default.
- W4200133119 type Work @default.
- W4200133119 citedByCount "5" @default.
- W4200133119 countsByYear W42001331192022 @default.
- W4200133119 countsByYear W42001331192023 @default.
- W4200133119 crossrefType "journal-article" @default.
- W4200133119 hasAuthorship W4200133119A5033003782 @default.
- W4200133119 hasAuthorship W4200133119A5060075550 @default.
- W4200133119 hasAuthorship W4200133119A5063459103 @default.
- W4200133119 hasAuthorship W4200133119A5065893772 @default.
- W4200133119 hasBestOaLocation W42001331191 @default.
- W4200133119 hasConcept C104317684 @default.
- W4200133119 hasConcept C121608353 @default.
- W4200133119 hasConcept C126322002 @default.
- W4200133119 hasConcept C143998085 @default.
- W4200133119 hasConcept C177713679 @default.
- W4200133119 hasConcept C182979987 @default.
- W4200133119 hasConcept C185592680 @default.
- W4200133119 hasConcept C2777626846 @default.
- W4200133119 hasConcept C2777701055 @default.
- W4200133119 hasConcept C2777742743 @default.
- W4200133119 hasConcept C2779962180 @default.
- W4200133119 hasConcept C2780030458 @default.
- W4200133119 hasConcept C2781187634 @default.
- W4200133119 hasConcept C526805850 @default.
- W4200133119 hasConcept C55493867 @default.
- W4200133119 hasConcept C71924100 @default.
- W4200133119 hasConcept C82381507 @default.
- W4200133119 hasConceptScore W4200133119C104317684 @default.
- W4200133119 hasConceptScore W4200133119C121608353 @default.
- W4200133119 hasConceptScore W4200133119C126322002 @default.
- W4200133119 hasConceptScore W4200133119C143998085 @default.
- W4200133119 hasConceptScore W4200133119C177713679 @default.
- W4200133119 hasConceptScore W4200133119C182979987 @default.
- W4200133119 hasConceptScore W4200133119C185592680 @default.
- W4200133119 hasConceptScore W4200133119C2777626846 @default.
- W4200133119 hasConceptScore W4200133119C2777701055 @default.
- W4200133119 hasConceptScore W4200133119C2777742743 @default.
- W4200133119 hasConceptScore W4200133119C2779962180 @default.
- W4200133119 hasConceptScore W4200133119C2780030458 @default.
- W4200133119 hasConceptScore W4200133119C2781187634 @default.
- W4200133119 hasConceptScore W4200133119C526805850 @default.
- W4200133119 hasConceptScore W4200133119C55493867 @default.
- W4200133119 hasConceptScore W4200133119C71924100 @default.
- W4200133119 hasConceptScore W4200133119C82381507 @default.
- W4200133119 hasIssue "6" @default.
- W4200133119 hasLocation W42001331191 @default.
- W4200133119 hasOpenAccess W4200133119 @default.
- W4200133119 hasPrimaryLocation W42001331191 @default.
- W4200133119 hasRelatedWork W2337507927 @default.
- W4200133119 hasRelatedWork W2912107322 @default.
- W4200133119 hasRelatedWork W2947816590 @default.
- W4200133119 hasRelatedWork W2955997569 @default.
- W4200133119 hasRelatedWork W3103224069 @default.
- W4200133119 hasRelatedWork W3118791001 @default.
- W4200133119 hasRelatedWork W4200133119 @default.
- W4200133119 hasRelatedWork W4310823917 @default.
- W4200133119 hasRelatedWork W4383852775 @default.
- W4200133119 hasRelatedWork W4384522806 @default.
- W4200133119 hasVolume "67" @default.
- W4200133119 isParatext "false" @default.
- W4200133119 isRetracted "false" @default.
- W4200133119 workType "article" @default.