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- W4200137667 endingPage "119020" @default.
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- W4200137667 abstract "Amniotic membrane (AM) has been utilized as a wound dressing extensively. Given the importance of oxygen in wound healing, here we have reported the fabrication and characterization of an oxygen-generating wound dressing based on AM. This construct was composed of H2O2-loaded polylactic acid (PLA) microparticles embedded within a chitosan/β-glycerophosphate (β-GP) thermosensitive hydrogel covered with a layer of decellularized human-AM. The microparticles had a diameter of 4.48 ± 1.8 μm, an encapsulation efficiency of 44.172 ± 4.49%, and generated oxygen for at least 7 days. The hybrid construct was formed at 32.4 ± 2 °C, had a porous structure (84.69 ± 8.34%) with a pore size of 46.72 ± 26.21 μm. The hydrogel/dAM extract was non-toxic after 7 days based on our MTT results, and the final composite supported cell growth and adhesion. This sample had the most negligible blood cell adhesion with less than 5% hemolysis. Our results indicate the proposed structure's desirable biological, chemical, and physical properties as an active wound dressing." @default.
- W4200137667 created "2021-12-31" @default.
- W4200137667 creator A5028480614 @default.
- W4200137667 creator A5047508546 @default.
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- W4200137667 date "2022-04-01" @default.
- W4200137667 modified "2023-10-11" @default.
- W4200137667 title "A hybrid oxygen-generating wound dressing based on chitosan thermosensitive hydrogel and decellularized amniotic membrane" @default.
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- W4200137667 doi "https://doi.org/10.1016/j.carbpol.2021.119020" @default.
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