Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200141981> ?p ?o ?g. }
- W4200141981 endingPage "1527" @default.
- W4200141981 startingPage "1527" @default.
- W4200141981 abstract "Carbapenem resistance among Klebsiella pneumoniae isolates is often related to carbapenemase genes, located in genetic transmissible elements, particularly the blaKPC gene, which variants are spread in several countries. Recently, reports of K. pneumoniae isolates harboring the blaNDM gene have increased dramatically along with the dissemination of epidemic high-risk clones (HRCs). In the present study, we report the multiclonal spread of New Delhi metallo-beta-lactamase (NDM)-producing K. pneumoniae in different healthcare institutions in the state of Pará, Northern Brazil. A total of 23 NDM-producing isolates were tested regarding antimicrobial susceptibility testing features, screening of carbapenemase genes, and genotyping by multilocus sequencing typing (MLST). All K. pneumoniae isolates were determined as multidrug-resistant (MDR), being mainly resistant to carbapenems, cephalosporins, and fluoroquinolones. The blaNDM-7 (60.9%—14/23) and blaNDM-1 (34.8%—8/23) variants were detected. MLST genotyping revealed the predomination of HRCs, including ST11/CC258, ST340/CC258, ST15/CC15, ST392/CC147, among others. To conclude, the present study reveals the contribution of HRCs and non-HRCs in the spread of NDM-1 and NDM-7-producing K. pneumoniae isolates in Northern (Amazon region) Brazil, along with the first detection of NDM-7 variant in Latin America and Brazil, highlighting the need for surveillance and control of strains that may negatively impact healthcare and antimicrobial resistance." @default.
- W4200141981 created "2021-12-31" @default.
- W4200141981 creator A5010924675 @default.
- W4200141981 creator A5014092465 @default.
- W4200141981 creator A5040433236 @default.
- W4200141981 creator A5044887003 @default.
- W4200141981 creator A5091685112 @default.
- W4200141981 date "2021-12-14" @default.
- W4200141981 modified "2023-10-10" @default.
- W4200141981 title "The Spread of NDM-1 and NDM-7-Producing Klebsiella pneumoniae Is Driven by Multiclonal Expansion of High-Risk Clones in Healthcare Institutions in the State of Pará, Brazilian Amazon Region" @default.
- W4200141981 cites W1898605557 @default.
- W4200141981 cites W1978441703 @default.
- W4200141981 cites W1996457165 @default.
- W4200141981 cites W2069513631 @default.
- W4200141981 cites W2078043965 @default.
- W4200141981 cites W2078863586 @default.
- W4200141981 cites W2080211832 @default.
- W4200141981 cites W2088298366 @default.
- W4200141981 cites W2088527369 @default.
- W4200141981 cites W2100475906 @default.
- W4200141981 cites W2111203035 @default.
- W4200141981 cites W2120195055 @default.
- W4200141981 cites W2122500600 @default.
- W4200141981 cites W2141973118 @default.
- W4200141981 cites W2142182807 @default.
- W4200141981 cites W2142343447 @default.
- W4200141981 cites W2145111808 @default.
- W4200141981 cites W2152413896 @default.
- W4200141981 cites W2153679512 @default.
- W4200141981 cites W2155344369 @default.
- W4200141981 cites W2191549327 @default.
- W4200141981 cites W2243622740 @default.
- W4200141981 cites W2335719312 @default.
- W4200141981 cites W2419220498 @default.
- W4200141981 cites W2483236535 @default.
- W4200141981 cites W2538077101 @default.
- W4200141981 cites W2545140005 @default.
- W4200141981 cites W2586977263 @default.
- W4200141981 cites W2624971140 @default.
- W4200141981 cites W2719956794 @default.
- W4200141981 cites W2732541891 @default.
- W4200141981 cites W2764144168 @default.
- W4200141981 cites W2769899821 @default.
- W4200141981 cites W2770826029 @default.
- W4200141981 cites W2773390269 @default.
- W4200141981 cites W2784170655 @default.
- W4200141981 cites W2901222459 @default.
- W4200141981 cites W2903017774 @default.
- W4200141981 cites W2912612396 @default.
- W4200141981 cites W2913241047 @default.
- W4200141981 cites W2915092071 @default.
- W4200141981 cites W2918082491 @default.
- W4200141981 cites W2939265616 @default.
- W4200141981 cites W2947607596 @default.
- W4200141981 cites W2951565351 @default.
- W4200141981 cites W2960716087 @default.
- W4200141981 cites W2965957986 @default.
- W4200141981 cites W2972779137 @default.
- W4200141981 cites W2973617749 @default.
- W4200141981 cites W2988960900 @default.
- W4200141981 cites W2997147861 @default.
- W4200141981 cites W3005968613 @default.
- W4200141981 cites W3014640875 @default.
- W4200141981 cites W3015285500 @default.
- W4200141981 cites W3024041655 @default.
- W4200141981 cites W3032890351 @default.
- W4200141981 cites W3039467762 @default.
- W4200141981 cites W3040267688 @default.
- W4200141981 cites W3043558169 @default.
- W4200141981 cites W3047281724 @default.
- W4200141981 cites W3060710023 @default.
- W4200141981 cites W3088048783 @default.
- W4200141981 cites W3091509160 @default.
- W4200141981 cites W3092505639 @default.
- W4200141981 cites W3093882581 @default.
- W4200141981 cites W3106844590 @default.
- W4200141981 cites W3136606681 @default.
- W4200141981 cites W3152642588 @default.
- W4200141981 cites W3164300582 @default.
- W4200141981 cites W3186816492 @default.
- W4200141981 cites W3191874570 @default.
- W4200141981 cites W3195733379 @default.
- W4200141981 cites W3202321333 @default.
- W4200141981 cites W937611577 @default.
- W4200141981 doi "https://doi.org/10.3390/antibiotics10121527" @default.
- W4200141981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34943739" @default.
- W4200141981 hasPublicationYear "2021" @default.
- W4200141981 type Work @default.
- W4200141981 citedByCount "6" @default.
- W4200141981 countsByYear W42001419812022 @default.
- W4200141981 countsByYear W42001419812023 @default.
- W4200141981 crossrefType "journal-article" @default.
- W4200141981 hasAuthorship W4200141981A5010924675 @default.
- W4200141981 hasAuthorship W4200141981A5014092465 @default.
- W4200141981 hasAuthorship W4200141981A5040433236 @default.
- W4200141981 hasAuthorship W4200141981A5044887003 @default.
- W4200141981 hasAuthorship W4200141981A5091685112 @default.
- W4200141981 hasBestOaLocation W42001419811 @default.