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- W4200146564 abstract "During metastasis, invading tumor cells and circulating tumor cells (CTC) face multiple mechanical challenges during migration through narrow pores and cell squeezing. However, little is known on the importance and consequences of mechanical stress for tumor progression and success in invading a new organ. Recently, several studies have shown that cell constriction can lead to nuclear envelope rupture (NER) during interphase. This loss of proper nuclear compartmentalization has a profound effect on the genome, being a key driver for the genome evolution needed for tumor progression. More than just being a source of genomic alterations, the transient nuclear envelope collapse can also support metastatic growth by several mechanisms involving the innate immune response cGAS/STING pathway. In this review we will describe the importance of the underestimated role of cellular squeezing in the progression of tumorigenesis. We will describe the complexity and difficulty for tumor cells to reach the metastatic site, detail the genomic aberration diversity due to NER, and highlight the importance of the activation of the innate immune pathway on cell survival. Cellular adaptation and nuclear deformation can be the key to the metastasis success in many unsuspected aspects." @default.
- W4200146564 created "2021-12-31" @default.
- W4200146564 creator A5044446190 @default.
- W4200146564 creator A5073061508 @default.
- W4200146564 creator A5086919061 @default.
- W4200146564 date "2021-12-24" @default.
- W4200146564 modified "2023-09-30" @default.
- W4200146564 title "Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success?" @default.
- W4200146564 cites W1601755300 @default.
- W4200146564 cites W1760215417 @default.
- W4200146564 cites W1976541550 @default.
- W4200146564 cites W1993913242 @default.
- W4200146564 cites W1995816679 @default.
- W4200146564 cites W2008541912 @default.
- W4200146564 cites W2012987872 @default.
- W4200146564 cites W2016661249 @default.
- W4200146564 cites W2019522696 @default.
- W4200146564 cites W2030637965 @default.
- W4200146564 cites W2039354378 @default.
- W4200146564 cites W2048143387 @default.
- W4200146564 cites W2066304642 @default.
- W4200146564 cites W2066907008 @default.
- W4200146564 cites W2067829376 @default.
- W4200146564 cites W2076782790 @default.
- W4200146564 cites W2077145482 @default.
- W4200146564 cites W2082239705 @default.
- W4200146564 cites W2095617425 @default.
- W4200146564 cites W2097988743 @default.
- W4200146564 cites W2099610218 @default.
- W4200146564 cites W2117637900 @default.
- W4200146564 cites W2121961422 @default.
- W4200146564 cites W2124376174 @default.
- W4200146564 cites W2125254652 @default.
- W4200146564 cites W2135745724 @default.
- W4200146564 cites W2171577674 @default.
- W4200146564 cites W2186917099 @default.
- W4200146564 cites W2197269124 @default.
- W4200146564 cites W2303653884 @default.
- W4200146564 cites W2311649981 @default.
- W4200146564 cites W2336248112 @default.
- W4200146564 cites W2395943362 @default.
- W4200146564 cites W2560567639 @default.
- W4200146564 cites W2576308038 @default.
- W4200146564 cites W2580868078 @default.
- W4200146564 cites W2605236266 @default.
- W4200146564 cites W2605283453 @default.
- W4200146564 cites W2606812723 @default.
- W4200146564 cites W2617004827 @default.
- W4200146564 cites W2618634776 @default.
- W4200146564 cites W2619938277 @default.
- W4200146564 cites W2762611634 @default.
- W4200146564 cites W2764186557 @default.
- W4200146564 cites W2775781476 @default.
- W4200146564 cites W2783667606 @default.
- W4200146564 cites W2792338542 @default.
- W4200146564 cites W2800075133 @default.
- W4200146564 cites W2800736744 @default.
- W4200146564 cites W2895293517 @default.
- W4200146564 cites W2896737648 @default.
- W4200146564 cites W2902618639 @default.
- W4200146564 cites W2902649319 @default.
- W4200146564 cites W2912696928 @default.
- W4200146564 cites W2914940244 @default.
- W4200146564 cites W2917002600 @default.
- W4200146564 cites W2918490000 @default.
- W4200146564 cites W2920347438 @default.
- W4200146564 cites W2921875691 @default.
- W4200146564 cites W2931582083 @default.
- W4200146564 cites W2944115166 @default.
- W4200146564 cites W2956135855 @default.
- W4200146564 cites W2963344481 @default.
- W4200146564 cites W2969709096 @default.
- W4200146564 cites W2970250038 @default.
- W4200146564 cites W2970593976 @default.
- W4200146564 cites W2977346494 @default.
- W4200146564 cites W2978258146 @default.
- W4200146564 cites W2979620384 @default.
- W4200146564 cites W2981548686 @default.
- W4200146564 cites W2982425966 @default.
- W4200146564 cites W2991771410 @default.
- W4200146564 cites W2994568919 @default.
- W4200146564 cites W2995171541 @default.
- W4200146564 cites W2999990233 @default.
- W4200146564 cites W3000999925 @default.
- W4200146564 cites W3012887203 @default.
- W4200146564 cites W3015203843 @default.
- W4200146564 cites W3015279582 @default.
- W4200146564 cites W3016718031 @default.
- W4200146564 cites W3016907416 @default.
- W4200146564 cites W3022927847 @default.
- W4200146564 cites W3035967781 @default.
- W4200146564 cites W3037469178 @default.
- W4200146564 cites W3040485407 @default.
- W4200146564 cites W3044175205 @default.
- W4200146564 cites W3044343904 @default.
- W4200146564 cites W3051810335 @default.
- W4200146564 cites W3082714866 @default.
- W4200146564 cites W3091643843 @default.