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• W4200148425 abstract "Abstract The devastation caused by SARS-CoV-2 has made clear the importance of pandemic preparedness. To address future zoonotic outbreaks due to related viruses in the sarbecovirus subgenus, we identified a human monoclonal antibody, 10-40, that neutralized or bound all sarbecoviruses tested in vitro and protected against SARS-CoV-2 and SARS-CoV in vivo . Comparative studies with other receptor-binding domain (RBD)-directed antibodies showed 10-40 to have the greatest breadth against sarbecoviruses and thus its promise as an agent for pandemic preparedness. Moreover, structural analyses on 10-40 and similar antibodies not only defined an epitope cluster in the inner face of the RBD that is well conserved among sarbecoviruses, but also uncovered a new antibody class with a common CDRH3 motif. Our analyses also suggested that elicitation of this class of antibodies may not be overly difficult, an observation that bodes well for the development of a pan-sarbecovirus vaccine. One sentence summary A monoclonal antibody that neutralizes or binds all sarbecoviruses tested and represents a reproducible antibody class." @default.
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• W4200148425 date "2021-12-14" @default.
• W4200148425 modified "2023-10-16" @default.
• W4200148425 title "Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses" @default.
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• W4200148425 doi "https://doi.org/10.1101/2021.12.11.472236" @default.
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