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- W4200152306 endingPage "57" @default.
- W4200152306 startingPage "13" @default.
- W4200152306 abstract "The hepatitis C virus (HCV) infects over 75 million individuals worldwide and is a major cause of liver fibrosis, cirrhosis and liver cancer. The first therapy developed to treat HCV was interferon, however, cure rates using interferon therapy were modest and the treatment was frequently accompanied by significant intolerable side effects. Attempts to develop therapies to reduce the use of interferon or eliminate its use completely focused on the discovery of direct-acting antiviral agents targeting key viral proteins critical for the virus' survival. Several of these key viral proteins (nonstructural proteins) were identified as druggable targets. These targets included the NS3/4A viral protease, the NS5A viral replication complex protein and the NS5B viral polymerase. The discovery and development of small molecule drugs against these proteins proved to be effective at dramatically reducing viral titers in clinical studies. Eventually, the combination of these drugs resulted in the development of regimens that cured HCV infected patients after only 8-12 weeks of therapy and without the use of interferon. This chapter describes the drugs that entered clinical trials against each of the key viral targets and what key drug combinations contributed to major progress in the journey toward an HCV cure." @default.
- W4200152306 created "2021-12-31" @default.
- W4200152306 creator A5005886386 @default.
- W4200152306 date "2021-12-03" @default.
- W4200152306 modified "2023-09-26" @default.
- W4200152306 title "Curing Hepatitis C with Direct‐Acting Antiviral Therapy" @default.
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