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• W4200153986 abstract "The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the biological microenvironment by filling the injured cavity area and increasing neuronal differentiation of neural stem cells (NSCs) to repair SCI. However, the method is characterized by several challenges including irregular wounds, and mechanical and electrical mismatch of the material-tissue interface. In the current study, a unique and facile agarose/gelatin/polypyrrole (Aga/Gel/PPy, AGP3) hydrogel with similar conductivity and modulus as the spinal cord was developed by altering the concentration of Aga and PPy. The gelation occurred through non-covalent interactions, and the physically crosslinked features made the AGP3 hydrogels injectable. In vitro cultures showed that AGP3 hydrogel exhibited excellent biocompatibility, and promoted differentiation of NSCs toward neurons whereas it inhibited over-proliferation of astrocytes. The in vivo implanted AGP3 hydrogel completely covered the tissue defects and reduced injured cavity areas. In vivo studies further showed that the AGP3 hydrogel provided a biocompatible microenvironment for promoting endogenous neurogenesis rather than glial fibrosis formation, resulting in significant functional recovery. RNA sequencing analysis further indicated that AGP3 hydrogel significantly modulated expression of neurogenesis-related genes through intracellular Ca2+ signaling cascades. Overall, this supramolecular strategy produces AGP3 hydrogel that can be used as favorable biomaterials for SCI repair by filling the cavity and imitating the physiological properties of the spinal cord." @default.
• W4200153986 created "2021-12-31" @default.
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• W4200153986 date "2022-09-01" @default.
• W4200153986 modified "2023-10-14" @default.
• W4200153986 title "A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair" @default.
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• W4200153986 cites W2076156211 @default.
• W4200153986 cites W2098737512 @default.
• W4200153986 cites W2275546541 @default.
• W4200153986 cites W2329509796 @default.
• W4200153986 cites W2512536240 @default.
• W4200153986 cites W2513457468 @default.
• W4200153986 cites W2527719646 @default.
• W4200153986 cites W2594567835 @default.
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• W4200153986 cites W2611604513 @default.
• W4200153986 cites W2658281240 @default.
• W4200153986 cites W2754420233 @default.
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• W4200153986 cites W2904837629 @default.
• W4200153986 cites W2908359749 @default.
• W4200153986 cites W2909670723 @default.
• W4200153986 cites W2914271953 @default.
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• W4200153986 cites W2948721026 @default.
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• W4200153986 cites W2993640846 @default.
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• W4200153986 cites W3008581914 @default.
• W4200153986 cites W3010171238 @default.
• W4200153986 cites W3010421836 @default.
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• W4200153986 cites W3029684493 @default.
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• W4200153986 cites W3049381890 @default.
• W4200153986 cites W3083296311 @default.
• W4200153986 cites W3084404495 @default.
• W4200153986 cites W3084807264 @default.
• W4200153986 cites W3087270057 @default.
• W4200153986 cites W3089369228 @default.
• W4200153986 cites W3094553171 @default.
• W4200153986 cites W3105722743 @default.
• W4200153986 cites W3106992221 @default.
• W4200153986 cites W3109885735 @default.
• W4200153986 cites W3112169826 @default.
• W4200153986 cites W3127915764 @default.
• W4200153986 cites W3128127189 @default.
• W4200153986 cites W3157466197 @default.
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• W4200153986 cites W3167880361 @default.
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• W4200153986 doi "https://doi.org/10.1016/j.bioactmat.2021.11.032" @default.
• W4200153986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35386356" @default.
• W4200153986 hasPublicationYear "2022" @default.
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