FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200154017> ?p ?o ?g. }

• W4200154017 abstract "Abstract Aims Direct oral anticoagulants (DOACs) are known for lower bleeding risk than vitamin K antagonist (VKA) in patients with atrial fibrillation (AF). To date, it has not been established whether in such population DOAC may offer reduction of bleeding complication in patients undergoing cardiac implantable electronic device (CIED) implant or revision (substitution, upgrade, or downgrade). We evaluated whether DOACs compared to VKAs, decrease bleeding complications at the time of CIED implant in patients with AF, requiring oral anticoagulant therapy. Methods and results We present a monocentric observational retrospective study. Patients undergoing implant, generator replacement, or upgrading/downgrading of an intracardiac device (PM, ICD, or CRT) between January 2015 and March 2021 with AF undergoing DOAC or VKA were included. The comparison of risk of clinically significant pocket hematoma at 30-days follow-up in the two-treatment group [DOAC vs. VKA and DOAC vs. VKA without low molecular weight eparin (LMWH) bridge] was performed. Cox proportional hazards regression analysis including main clinical findings was performed to test the primary endpoint. Propensity score matching analysis was performed, with inversed proportional weighted (IPW) propensity score included in the multivariate analysis. 311 patients were included, 146 (46.9%) treated with DOAC and 165 (53.1%) treated with VKA. The incidence pocket haematoma was significantly reduced in patients treated with DOAC compared with VKA (3.4% vs. 13.3%, respectively, P = 0.002), a finding confirmed on multivariate analysis (HR: 3.02, CI: 1.10–8.29, P = 0.032). The incidence of pocket haematoma in patients on DOAC vs. VKA without LMWH bridge therapy was found to be significantly higher in the latter group of patients (P = 0.033, HR: 2.93, CI: 1.01–8.49, P = 0.48). After adjusting at propensity score with IPW, DOAC use showed decreased risk of pocket haematoma (HR: 0.29, CI: 0.09–0.95, P = 0.42). Conclusions In patients with atrial fibrillation undergoing CIED implant or revision, DOAC therapy appears to be associated with lower risk of event-related pocket haematoma at 30-day follow-up, even in the absence of bridging with LWMH. Such findings are hypothesis-generating." @default.
• W4200154017 created "2021-12-31" @default.
• W4200154017 creator A5000595044 @default.
• W4200154017 creator A5011388124 @default.
• W4200154017 creator A5015075755 @default.
• W4200154017 creator A5026874618 @default.
• W4200154017 creator A5033337882 @default.
• W4200154017 creator A5033373672 @default.
• W4200154017 creator A5074205679 @default.
• W4200154017 creator A5090053039 @default.
• W4200154017 creator A5090804195 @default.
• W4200154017 date "2021-12-01" @default.
• W4200154017 modified "2023-09-27" @default.
• W4200154017 title "286 Incidence of pocket haematoma with different anticoagulation strategies in patients undergoing cardiac implantable device implant or revision" @default.
• W4200154017 doi "https://doi.org/10.1093/eurheartj/suab127.044" @default.
• W4200154017 hasPublicationYear "2021" @default.
• W4200154017 type Work @default.
• W4200154017 citedByCount "0" @default.
• W4200154017 crossrefType "journal-article" @default.
• W4200154017 hasAuthorship W4200154017A5000595044 @default.
• W4200154017 hasAuthorship W4200154017A5011388124 @default.
• W4200154017 hasAuthorship W4200154017A5015075755 @default.
• W4200154017 hasAuthorship W4200154017A5026874618 @default.
• W4200154017 hasAuthorship W4200154017A5033337882 @default.
• W4200154017 hasAuthorship W4200154017A5033373672 @default.
• W4200154017 hasAuthorship W4200154017A5074205679 @default.
• W4200154017 hasAuthorship W4200154017A5090053039 @default.
• W4200154017 hasAuthorship W4200154017A5090804195 @default.
• W4200154017 hasBestOaLocation W42001540171 @default.
• W4200154017 hasConcept C120665830 @default.
• W4200154017 hasConcept C121332964 @default.
• W4200154017 hasConcept C126322002 @default.
• W4200154017 hasConcept C141071460 @default.
• W4200154017 hasConcept C17923572 @default.
• W4200154017 hasConcept C2776301958 @default.
• W4200154017 hasConcept C2776704044 @default.
• W4200154017 hasConcept C2779161974 @default.
• W4200154017 hasConcept C2781411149 @default.
• W4200154017 hasConcept C2908647359 @default.
• W4200154017 hasConcept C50382708 @default.
• W4200154017 hasConcept C61511704 @default.
• W4200154017 hasConcept C71924100 @default.
• W4200154017 hasConcept C99454951 @default.
• W4200154017 hasConceptScore W4200154017C120665830 @default.
• W4200154017 hasConceptScore W4200154017C121332964 @default.
• W4200154017 hasConceptScore W4200154017C126322002 @default.
• W4200154017 hasConceptScore W4200154017C141071460 @default.
• W4200154017 hasConceptScore W4200154017C17923572 @default.
• W4200154017 hasConceptScore W4200154017C2776301958 @default.
• W4200154017 hasConceptScore W4200154017C2776704044 @default.
• W4200154017 hasConceptScore W4200154017C2779161974 @default.
• W4200154017 hasConceptScore W4200154017C2781411149 @default.
• W4200154017 hasConceptScore W4200154017C2908647359 @default.
• W4200154017 hasConceptScore W4200154017C50382708 @default.
• W4200154017 hasConceptScore W4200154017C61511704 @default.
• W4200154017 hasConceptScore W4200154017C71924100 @default.
• W4200154017 hasConceptScore W4200154017C99454951 @default.
• W4200154017 hasIssue "Supplement_G" @default.
• W4200154017 hasLocation W42001540171 @default.
• W4200154017 hasOpenAccess W4200154017 @default.
• W4200154017 hasPrimaryLocation W42001540171 @default.
• W4200154017 hasRelatedWork W2267354991 @default.
• W4200154017 hasRelatedWork W2625135257 @default.
• W4200154017 hasRelatedWork W2759320956 @default.
• W4200154017 hasRelatedWork W2761303495 @default.
• W4200154017 hasRelatedWork W2763816051 @default.
• W4200154017 hasRelatedWork W2981412304 @default.
• W4200154017 hasRelatedWork W2981420901 @default.
• W4200154017 hasRelatedWork W3048684844 @default.
• W4200154017 hasRelatedWork W3175289208 @default.
• W4200154017 hasRelatedWork W4312192837 @default.
• W4200154017 hasVolume "23" @default.
• W4200154017 isParatext "false" @default.
• W4200154017 isRetracted "false" @default.
• W4200154017 workType "article" @default.