FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200155910> ?p ?o ?g. }

• W4200155910 endingPage "e2139558" @default.
• W4200155910 startingPage "e2139558" @default.
• W4200155910 abstract "<h3>Importance</h3> Several meta-analyses of randomized clinical trials (RCTs) have demonstrated the many health benefits of intermittent fasting (IF). However, there has been little synthesis of the strength and quality of this evidence in aggregate to date. <h3>Objective</h3> To grade the evidence from published meta-analyses of RCTs that assessed the associations of IF (zero-calorie alternate-day fasting, modified alternate-day fasting, the 5:2 diet, and time-restricted eating) with obesity-related health outcomes. <h3>Evidence Review</h3> PubMed, Embase, and Cochrane database of systematic reviews were searched from database inception to January 12, 2021. Data analysis was conducted from April 2021 through July 2021. Meta-analyses of RCTs investigating effects of IF in adults were included. The effect sizes of IF were recalculated using a random-effects model. We assessed the quality of evidence per association by applying the GRADE criteria (Grading of Recommendations, Assessment, Development, and Evaluations) as high, moderate, low, and very low. <h3>Findings</h3> A total of 11 meta-analyses comprising 130 RCTs (median [IQR] sample size, 38 [24-69] participants; median [IQR] follow-up period, 3 [2-5] months) were included describing 104 unique associations of different types of IF with obesity-related health outcomes (median [IQR] studies per association, 4 [3-5]). There were 28 statistically significant associations (27%) that demonstrated the beneficial outcomes for body mass index, body weight, fat mass, low-density lipoprotein cholesterol, total cholesterol, triglycerides, fasting plasma glucose, fasting insulin, homeostatic model assessment of insulin resistance, and blood pressure. IF was found to be associated with reduced fat-free mass. One significant association (1%) supported by high-quality evidence was modified alternate-day fasting for 1 to 2 months, which was associated with moderate reduction in body mass index in healthy adults and adults with overweight, obesity, or nonalcoholic fatty liver disease compared with regular diet. Six associations (6%) were supported by moderate quality evidence. The remaining associations found to be significant were supported by very low (75 associations [72%]) to low (22 associations [21%]) quality evidence. <h3>Conclusions and Relevance</h3> In this umbrella review, we found beneficial associations of IF with anthropometric and cardiometabolic outcomes supported by moderate to high quality of evidence, which supports the role of IF, especially modified alternate-day fasting, as a weight loss approach for adults with overweight or obesity. More clinical trials with long-term follow-up are needed to investigate the effects of IF on clinical outcomes such as cardiovascular events and mortality." @default.
• W4200155910 created "2021-12-31" @default.
• W4200155910 creator A5010499946 @default.
• W4200155910 creator A5013349830 @default.
• W4200155910 creator A5021457387 @default.
• W4200155910 creator A5031442144 @default.
• W4200155910 creator A5035159431 @default.
• W4200155910 creator A5038373228 @default.
• W4200155910 creator A5044348871 @default.
• W4200155910 creator A5052777903 @default.
• W4200155910 creator A5060214892 @default.
• W4200155910 date "2021-12-17" @default.
• W4200155910 modified "2023-10-11" @default.
• W4200155910 title "Intermittent Fasting and Obesity-Related Health Outcomes" @default.
• W4200155910 cites W1973914781 @default.
• W4200155910 cites W2004907923 @default.
• W4200155910 cites W2104868442 @default.
• W4200155910 cites W2107328434 @default.
• W4200155910 cites W2108868101 @default.
• W4200155910 cites W2122450633 @default.
• W4200155910 cites W2159654600 @default.
• W4200155910 cites W2410915092 @default.
• W4200155910 cites W2756578555 @default.
• W4200155910 cites W2883468517 @default.
• W4200155910 cites W2890533686 @default.
• W4200155910 cites W2906663197 @default.
• W4200155910 cites W2921359643 @default.
• W4200155910 cites W2931270080 @default.
• W4200155910 cites W2955331731 @default.
• W4200155910 cites W2964919899 @default.
• W4200155910 cites W2970684805 @default.
• W4200155910 cites W2977696925 @default.
• W4200155910 cites W2979922699 @default.
• W4200155910 cites W2980115439 @default.
• W4200155910 cites W2994010505 @default.
• W4200155910 cites W2994761268 @default.
• W4200155910 cites W2998467274 @default.
• W4200155910 cites W3022141775 @default.
• W4200155910 cites W3048326383 @default.
• W4200155910 cites W3094451998 @default.
• W4200155910 cites W3109837550 @default.
• W4200155910 cites W3130998577 @default.
• W4200155910 cites W4237172829 @default.
• W4200155910 cites W4241733303 @default.
• W4200155910 cites W4246521625 @default.
• W4200155910 cites W4250391585 @default.
• W4200155910 cites W78649709 @default.
• W4200155910 doi "https://doi.org/10.1001/jamanetworkopen.2021.39558" @default.
• W4200155910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34919135" @default.
• W4200155910 hasPublicationYear "2021" @default.
• W4200155910 type Work @default.
• W4200155910 citedByCount "75" @default.
• W4200155910 countsByYear W42001559102021 @default.
• W4200155910 countsByYear W42001559102022 @default.
• W4200155910 countsByYear W42001559102023 @default.
• W4200155910 crossrefType "journal-article" @default.
• W4200155910 hasAuthorship W4200155910A5010499946 @default.
• W4200155910 hasAuthorship W4200155910A5013349830 @default.
• W4200155910 hasAuthorship W4200155910A5021457387 @default.
• W4200155910 hasAuthorship W4200155910A5031442144 @default.
• W4200155910 hasAuthorship W4200155910A5035159431 @default.
• W4200155910 hasAuthorship W4200155910A5038373228 @default.
• W4200155910 hasAuthorship W4200155910A5044348871 @default.
• W4200155910 hasAuthorship W4200155910A5052777903 @default.
• W4200155910 hasAuthorship W4200155910A5060214892 @default.
• W4200155910 hasBestOaLocation W42001559101 @default.
• W4200155910 hasConcept C126322002 @default.
• W4200155910 hasConcept C168563851 @default.
• W4200155910 hasConcept C1862650 @default.
• W4200155910 hasConcept C2780221984 @default.
• W4200155910 hasConcept C511355011 @default.
• W4200155910 hasConcept C71924100 @default.
• W4200155910 hasConcept C95190672 @default.
• W4200155910 hasConceptScore W4200155910C126322002 @default.
• W4200155910 hasConceptScore W4200155910C168563851 @default.
• W4200155910 hasConceptScore W4200155910C1862650 @default.
• W4200155910 hasConceptScore W4200155910C2780221984 @default.
• W4200155910 hasConceptScore W4200155910C511355011 @default.
• W4200155910 hasConceptScore W4200155910C71924100 @default.
• W4200155910 hasConceptScore W4200155910C95190672 @default.
• W4200155910 hasIssue "12" @default.
• W4200155910 hasLocation W42001559101 @default.
• W4200155910 hasLocation W42001559102 @default.
• W4200155910 hasLocation W42001559103 @default.
• W4200155910 hasOpenAccess W4200155910 @default.
• W4200155910 hasPrimaryLocation W42001559101 @default.
• W4200155910 hasRelatedWork W1983507420 @default.
• W4200155910 hasRelatedWork W2097660065 @default.
• W4200155910 hasRelatedWork W2112436308 @default.
• W4200155910 hasRelatedWork W2121262108 @default.
• W4200155910 hasRelatedWork W2355769538 @default.
• W4200155910 hasRelatedWork W2373885168 @default.
• W4200155910 hasRelatedWork W2765710158 @default.
• W4200155910 hasRelatedWork W3145687392 @default.
• W4200155910 hasRelatedWork W4353035154 @default.
• W4200155910 hasRelatedWork W911162104 @default.
• W4200155910 hasVolume "4" @default.
• W4200155910 isParatext "false" @default.

• next