FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200156632> ?p ?o ?g. }

• W4200156632 abstract "Objective: To evaluate the effect of PuraStat (2.5% RADA16) administration on postoperative abdominal adhesion formation in an in vivo model. Methods: Anesthetized New Zealand white rabbits underwent cecal sidewall abrasion surgery in which the cecal serosa and juxtaposed parietal peritoneum were abraded after access through an abdominal midline incision. Eight animals were randomized to receive PuraStat administration at the interface of the injured tissues before incision closure, and five animals served as untreated controls. Treated animals received 3-12 ml PuraStat solution per lesion. Animals were sacrificed 14 days after surgery and examined for adhesion formation at the wound site. Results: At study terminus, adhesions were identified in 90% (9/10) of abraded cecum/peritoneal wound sites in untreated controls versus 25% (4/16) of PuraStat-treated sites (p = 0.004). Mean ± SD Total Adhesion Score (average of the values for extent + strength of the adhesion in both defects per animal; maximum score = 14 points) was significantly 76% lower in PuraStat-treated animals (2.0 ± 3.0 points) compared to untreated controls (8.2 ± 1.9 points) (p = 0.029). Mean adhesion coverage area of wound sites was 79% lower in PuraStat-treated animals than controls (p < 0.001), and mean adhesion durability was 72% lower in PuraStat-treated animals versus controls (p = 0.005). Remnant hydrogel was observed at the wound sites of 75% of treated animals at postoperative Day 14. Conclusion: PuraStat treatment has a positive protective effect in the cecal sidewall injury model, and significantly reduces abdominal adhesion formation at the interface of the injured cecum and overlying peritoneal sidewall defect." @default.
• W4200156632 created "2021-12-31" @default.
• W4200156632 creator A5014858881 @default.
• W4200156632 creator A5040732507 @default.
• W4200156632 creator A5061468881 @default.
• W4200156632 date "2021-12-10" @default.
• W4200156632 modified "2023-10-16" @default.
• W4200156632 title "PuraStat RADA16 Self-Assembling Peptide Reduces Postoperative Abdominal Adhesion Formation in a Rabbit Cecal Sidewall Injury Model" @default.
• W4200156632 cites W1912803105 @default.
• W4200156632 cites W1970735384 @default.
• W4200156632 cites W2001311766 @default.
• W4200156632 cites W2007188017 @default.
• W4200156632 cites W2010559822 @default.
• W4200156632 cites W2013753448 @default.
• W4200156632 cites W2019464863 @default.
• W4200156632 cites W2043475639 @default.
• W4200156632 cites W2086744783 @default.
• W4200156632 cites W2087070386 @default.
• W4200156632 cites W2110582342 @default.
• W4200156632 cites W2116980521 @default.
• W4200156632 cites W2132940857 @default.
• W4200156632 cites W2154410358 @default.
• W4200156632 cites W2181686151 @default.
• W4200156632 cites W2317376266 @default.
• W4200156632 cites W2525683625 @default.
• W4200156632 cites W2584847191 @default.
• W4200156632 cites W2609673344 @default.
• W4200156632 cites W2609936827 @default.
• W4200156632 cites W2653365239 @default.
• W4200156632 cites W2726402512 @default.
• W4200156632 cites W2743074371 @default.
• W4200156632 cites W2765194524 @default.
• W4200156632 cites W2768561022 @default.
• W4200156632 cites W2902088406 @default.
• W4200156632 cites W2902282736 @default.
• W4200156632 cites W2922386666 @default.
• W4200156632 cites W2991129078 @default.
• W4200156632 cites W3023270540 @default.
• W4200156632 cites W3043761846 @default.
• W4200156632 cites W3171984534 @default.
• W4200156632 doi "https://doi.org/10.3389/fbioe.2021.782224" @default.
• W4200156632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34957076" @default.
• W4200156632 hasPublicationYear "2021" @default.
• W4200156632 type Work @default.
• W4200156632 citedByCount "4" @default.
• W4200156632 countsByYear W42001566322022 @default.
• W4200156632 countsByYear W42001566322023 @default.
• W4200156632 crossrefType "journal-article" @default.
• W4200156632 hasAuthorship W4200156632A5014858881 @default.
• W4200156632 hasAuthorship W4200156632A5040732507 @default.
• W4200156632 hasAuthorship W4200156632A5061468881 @default.
• W4200156632 hasBestOaLocation W42001566321 @default.
• W4200156632 hasConcept C118231568 @default.
• W4200156632 hasConcept C126322002 @default.
• W4200156632 hasConcept C126894567 @default.
• W4200156632 hasConcept C127413603 @default.
• W4200156632 hasConcept C141071460 @default.
• W4200156632 hasConcept C150903083 @default.
• W4200156632 hasConcept C178790620 @default.
• W4200156632 hasConcept C185592680 @default.
• W4200156632 hasConcept C207001950 @default.
• W4200156632 hasConcept C2776001837 @default.
• W4200156632 hasConcept C2777507495 @default.
• W4200156632 hasConcept C2778754067 @default.
• W4200156632 hasConcept C2779983558 @default.
• W4200156632 hasConcept C2780269544 @default.
• W4200156632 hasConcept C2910641076 @default.
• W4200156632 hasConcept C71924100 @default.
• W4200156632 hasConcept C78519656 @default.
• W4200156632 hasConcept C84416704 @default.
• W4200156632 hasConcept C86803240 @default.
• W4200156632 hasConceptScore W4200156632C118231568 @default.
• W4200156632 hasConceptScore W4200156632C126322002 @default.
• W4200156632 hasConceptScore W4200156632C126894567 @default.
• W4200156632 hasConceptScore W4200156632C127413603 @default.
• W4200156632 hasConceptScore W4200156632C141071460 @default.
• W4200156632 hasConceptScore W4200156632C150903083 @default.
• W4200156632 hasConceptScore W4200156632C178790620 @default.
• W4200156632 hasConceptScore W4200156632C185592680 @default.
• W4200156632 hasConceptScore W4200156632C207001950 @default.
• W4200156632 hasConceptScore W4200156632C2776001837 @default.
• W4200156632 hasConceptScore W4200156632C2777507495 @default.
• W4200156632 hasConceptScore W4200156632C2778754067 @default.
• W4200156632 hasConceptScore W4200156632C2779983558 @default.
• W4200156632 hasConceptScore W4200156632C2780269544 @default.
• W4200156632 hasConceptScore W4200156632C2910641076 @default.
• W4200156632 hasConceptScore W4200156632C71924100 @default.
• W4200156632 hasConceptScore W4200156632C78519656 @default.
• W4200156632 hasConceptScore W4200156632C84416704 @default.
• W4200156632 hasConceptScore W4200156632C86803240 @default.
• W4200156632 hasLocation W42001566321 @default.
• W4200156632 hasLocation W42001566322 @default.
• W4200156632 hasLocation W42001566323 @default.
• W4200156632 hasLocation W42001566324 @default.
• W4200156632 hasOpenAccess W4200156632 @default.
• W4200156632 hasPrimaryLocation W42001566321 @default.
• W4200156632 hasRelatedWork W1576757575 @default.
• W4200156632 hasRelatedWork W1997477933 @default.
• W4200156632 hasRelatedWork W2046744808 @default.
• W4200156632 hasRelatedWork W2069328560 @default.

• next