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- W4200156776 endingPage "61" @default.
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- W4200156776 abstract "Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydrase inhibitor. Ethoxzolamide displayed an MIC50, against a panel of N. gonorrhoeae isolates, of 0.125 µg/mL, 16-fold more potent than acetazolamide, although both molecules exhibited almost similar potency against the gonococcal carbonic anhydrase enzyme (NgCA) in vitro. Acetazolamide displayed an inhibition constant (Ki) versus NgCA of 74 nM, while Ethoxzolamide's Ki was estimated to 94 nM. Therefore, the increased anti-gonococcal potency of ethoxzolamide was attributed to its increased permeability in N. gonorrhoeae as compared to that of acetazolamide. Both drugs demonstrated bacteriostatic activity against N. gonorrhoeae, exhibited post-antibiotic effects up to 10 hours, and resistance was not observed against both. Taken together, these results indicate that acetazolamide and ethoxzolamide warrant further investigation for translation into effective anti-N. gonorrhoeae agents." @default.
- W4200156776 created "2021-12-31" @default.
- W4200156776 creator A5016212469 @default.
- W4200156776 creator A5018378636 @default.
- W4200156776 creator A5026553668 @default.
- W4200156776 creator A5035013697 @default.
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- W4200156776 creator A5062624986 @default.
- W4200156776 creator A5068814682 @default.
- W4200156776 creator A5072597579 @default.
- W4200156776 creator A5076248949 @default.
- W4200156776 date "2021-12-11" @default.
- W4200156776 modified "2023-10-15" @default.
- W4200156776 title "Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of <i>Neisseria gonorrhoeae</i>" @default.
- W4200156776 cites W165181801 @default.
- W4200156776 cites W1783811381 @default.
- W4200156776 cites W1958799813 @default.
- W4200156776 cites W1964570752 @default.
- W4200156776 cites W1967139925 @default.
- W4200156776 cites W1974896920 @default.
- W4200156776 cites W1994449629 @default.
- W4200156776 cites W1994813225 @default.
- W4200156776 cites W1996045987 @default.
- W4200156776 cites W1997607664 @default.
- W4200156776 cites W1998555394 @default.
- W4200156776 cites W2002242769 @default.
- W4200156776 cites W2005153032 @default.
- W4200156776 cites W2014651956 @default.
- W4200156776 cites W2014994582 @default.
- W4200156776 cites W2016993708 @default.
- W4200156776 cites W2018537342 @default.
- W4200156776 cites W2025322665 @default.
- W4200156776 cites W2029953061 @default.
- W4200156776 cites W2031557942 @default.
- W4200156776 cites W2039932426 @default.
- W4200156776 cites W2047178318 @default.
- W4200156776 cites W2047925977 @default.
- W4200156776 cites W2048518725 @default.
- W4200156776 cites W2057334695 @default.
- W4200156776 cites W2062941476 @default.
- W4200156776 cites W2063909420 @default.
- W4200156776 cites W2074631079 @default.
- W4200156776 cites W2082205147 @default.
- W4200156776 cites W2083065597 @default.
- W4200156776 cites W2093313266 @default.
- W4200156776 cites W2124911476 @default.
- W4200156776 cites W2134201523 @default.
- W4200156776 cites W2135632920 @default.
- W4200156776 cites W2152009601 @default.
- W4200156776 cites W2158394863 @default.
- W4200156776 cites W2160592803 @default.
- W4200156776 cites W2166836200 @default.
- W4200156776 cites W2170133841 @default.
- W4200156776 cites W2176091836 @default.
- W4200156776 cites W2192116738 @default.
- W4200156776 cites W2202521614 @default.
- W4200156776 cites W2229363841 @default.
- W4200156776 cites W2300453592 @default.
- W4200156776 cites W2321970843 @default.
- W4200156776 cites W2322777826 @default.
- W4200156776 cites W2328355973 @default.
- W4200156776 cites W2424820092 @default.
- W4200156776 cites W2464932009 @default.
- W4200156776 cites W2529034339 @default.
- W4200156776 cites W2550348268 @default.
- W4200156776 cites W2562299499 @default.
- W4200156776 cites W2613613983 @default.
- W4200156776 cites W2725319213 @default.
- W4200156776 cites W2767759051 @default.
- W4200156776 cites W2790516073 @default.
- W4200156776 cites W2792262995 @default.
- W4200156776 cites W2796466342 @default.
- W4200156776 cites W2810380367 @default.
- W4200156776 cites W2920302906 @default.
- W4200156776 cites W2967273195 @default.
- W4200156776 cites W2973974748 @default.
- W4200156776 cites W2978418147 @default.
- W4200156776 cites W2980250486 @default.
- W4200156776 cites W2983601658 @default.
- W4200156776 cites W3013024294 @default.
- W4200156776 cites W3014161470 @default.
- W4200156776 cites W3017267081 @default.
- W4200156776 cites W3017340976 @default.
- W4200156776 cites W3021368001 @default.
- W4200156776 cites W3023266079 @default.
- W4200156776 cites W3038123490 @default.
- W4200156776 cites W3046074753 @default.
- W4200156776 cites W3047007341 @default.
- W4200156776 cites W3075820966 @default.
- W4200156776 cites W3079552435 @default.
- W4200156776 cites W3082442725 @default.
- W4200156776 cites W3088245433 @default.
- W4200156776 cites W3099353297 @default.
- W4200156776 cites W3111151712 @default.
- W4200156776 cites W3119390643 @default.
- W4200156776 cites W3122048911 @default.
- W4200156776 cites W3130289473 @default.
- W4200156776 cites W3137647537 @default.