Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200165419> ?p ?o ?g. }
- W4200165419 endingPage "476" @default.
- W4200165419 startingPage "465" @default.
- W4200165419 abstract "Autosomal dominant polycystic kidney disease (ADPKD) has phenotypic variability only partially explained by established biomarkers that do not readily assess pathologically important factors of inflammation and kidney fibrosis. We evaluated asymptomatic pyuria (AP), a surrogate marker of inflammation, as a biomarker for disease progression.We performed a retrospective cohort study of adult patients with ADPKD. Patients were divided into AP and no pyuria (NP) groups. We evaluated the effect of pyuria on kidney function and kidney volume. Longitudinal models evaluating kidney function and kidney volume rate of change with respect to incidences of AP were created.There were 687 included patients (347 AP, 340 NP). The AP group had more women (65% versus 49%). Median ages at kidney failure were 86 and 80 years in the NP and AP groups (log rank, P=0.49), respectively, for patients in Mayo Imaging Class (MIC) 1A-1B as compared with 59 and 55 years for patients in MIC 1C-1D-1E (log rank, P=0.02), respectively. Compared with the NP group, the rate of kidney function (ml/min per 1.73 m2 per year) decline shifted significantly after detection of AP in the models, including all patients (-1.48; P<0.001), patients in MIC 1A-1B (-1.79; P<0.001), patients in MIC 1C-1D-1E (-1.18; P<0.001), and patients with PKD1 (-1.04; P<0.001). Models evaluating kidney volume rate of growth showed no change after incidence of AP as compared with the NP group.AP is associated with kidney failure and faster kidney function decline irrespective of the ADPKD gene, cystic burden, and cystic growth. These results support AP as an enriching prognostic biomarker for the rate of disease progression." @default.
- W4200165419 created "2021-12-31" @default.
- W4200165419 creator A5002238355 @default.
- W4200165419 creator A5003304019 @default.
- W4200165419 creator A5008446942 @default.
- W4200165419 creator A5009002878 @default.
- W4200165419 creator A5009364196 @default.
- W4200165419 creator A5016336723 @default.
- W4200165419 creator A5017863972 @default.
- W4200165419 creator A5019773027 @default.
- W4200165419 creator A5021499784 @default.
- W4200165419 creator A5023154228 @default.
- W4200165419 creator A5025388066 @default.
- W4200165419 creator A5035332777 @default.
- W4200165419 creator A5039201232 @default.
- W4200165419 creator A5062219033 @default.
- W4200165419 creator A5070149489 @default.
- W4200165419 creator A5079819181 @default.
- W4200165419 creator A5089567071 @default.
- W4200165419 date "2022-03-31" @default.
- W4200165419 modified "2023-10-10" @default.
- W4200165419 title "Asymptomatic Pyuria as a Prognostic Biomarker in Autosomal Dominant Polycystic Kidney Disease" @default.
- W4200165419 cites W1584313983 @default.
- W4200165419 cites W1612317928 @default.
- W4200165419 cites W1924478590 @default.
- W4200165419 cites W1966368812 @default.
- W4200165419 cites W2001280008 @default.
- W4200165419 cites W2018619594 @default.
- W4200165419 cites W2028464499 @default.
- W4200165419 cites W2029190428 @default.
- W4200165419 cites W2036935323 @default.
- W4200165419 cites W2037756071 @default.
- W4200165419 cites W2053062434 @default.
- W4200165419 cites W2055919784 @default.
- W4200165419 cites W2065928247 @default.
- W4200165419 cites W2078789307 @default.
- W4200165419 cites W2083917318 @default.
- W4200165419 cites W2089154359 @default.
- W4200165419 cites W2096538221 @default.
- W4200165419 cites W2101067234 @default.
- W4200165419 cites W2116811919 @default.
- W4200165419 cites W2130211846 @default.
- W4200165419 cites W2130657993 @default.
- W4200165419 cites W2135053341 @default.
- W4200165419 cites W2140394797 @default.
- W4200165419 cites W2143990369 @default.
- W4200165419 cites W2146668712 @default.
- W4200165419 cites W2155965977 @default.
- W4200165419 cites W2159102199 @default.
- W4200165419 cites W2164628127 @default.
- W4200165419 cites W2168922778 @default.
- W4200165419 cites W2203078370 @default.
- W4200165419 cites W2265659983 @default.
- W4200165419 cites W2339322884 @default.
- W4200165419 cites W2418233049 @default.
- W4200165419 cites W2465919320 @default.
- W4200165419 cites W2592572788 @default.
- W4200165419 cites W2607216118 @default.
- W4200165419 cites W2762737041 @default.
- W4200165419 cites W2801180756 @default.
- W4200165419 cites W2809347302 @default.
- W4200165419 cites W2890311099 @default.
- W4200165419 cites W2890836726 @default.
- W4200165419 cites W2910221823 @default.
- W4200165419 cites W2979752261 @default.
- W4200165419 cites W2980851407 @default.
- W4200165419 cites W2995342647 @default.
- W4200165419 cites W3040659673 @default.
- W4200165419 cites W3102528795 @default.
- W4200165419 cites W3118211008 @default.
- W4200165419 cites W3135355396 @default.
- W4200165419 cites W3147258246 @default.
- W4200165419 cites W3148049993 @default.
- W4200165419 cites W3152017609 @default.
- W4200165419 cites W4248917587 @default.
- W4200165419 doi "https://doi.org/10.34067/kid.0004292021" @default.
- W4200165419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35582184" @default.
- W4200165419 hasPublicationYear "2022" @default.
- W4200165419 type Work @default.
- W4200165419 citedByCount "1" @default.
- W4200165419 countsByYear W42001654192023 @default.
- W4200165419 crossrefType "journal-article" @default.
- W4200165419 hasAuthorship W4200165419A5002238355 @default.
- W4200165419 hasAuthorship W4200165419A5003304019 @default.
- W4200165419 hasAuthorship W4200165419A5008446942 @default.
- W4200165419 hasAuthorship W4200165419A5009002878 @default.
- W4200165419 hasAuthorship W4200165419A5009364196 @default.
- W4200165419 hasAuthorship W4200165419A5016336723 @default.
- W4200165419 hasAuthorship W4200165419A5017863972 @default.
- W4200165419 hasAuthorship W4200165419A5019773027 @default.
- W4200165419 hasAuthorship W4200165419A5021499784 @default.
- W4200165419 hasAuthorship W4200165419A5023154228 @default.
- W4200165419 hasAuthorship W4200165419A5025388066 @default.
- W4200165419 hasAuthorship W4200165419A5035332777 @default.
- W4200165419 hasAuthorship W4200165419A5039201232 @default.
- W4200165419 hasAuthorship W4200165419A5062219033 @default.
- W4200165419 hasAuthorship W4200165419A5070149489 @default.
- W4200165419 hasAuthorship W4200165419A5079819181 @default.