Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200173896> ?p ?o ?g. }
- W4200173896 endingPage "93" @default.
- W4200173896 startingPage "73" @default.
- W4200173896 abstract "In aging males, androgen production by testicular Leydig cells decreases at a rate of approximately 1% per year. Phenolic compounds may enhance testosterone biosynthesis and delay the onset of male hypogonadism. Gigantol is a bibenzyl compound isolated from several types of orchids of the genus Dendrobium. This compound has various biological activities, including antioxidant activity. However, its capacity to regulate gene expression and steroid production in testicular Leydig cells has never been evaluated. We investigated the effect of gigantol on MA-10 Leydig cells' gene expression using an RNA-Seq approach. To further investigate the structure-function relationship of the hydroxy-methoxyphenyl moiety of gigantol, experiments were also performed with ferulic acid and isoferulic acid. According to transcriptomic analysis, all genes coding for cholesterol biosynthesis-related enzymes are increased in response to gigantol treatment, resulting in increased lipid droplets accumulation. Moreover, treatments with 10 μM gigantol increased StAR protein levels and progesterone production from MA-10 Leydig cells. However, neither ferulic acid nor isoferulic acid influenced StAR protein synthesis and progesterone production in MA-10 Leydig cells. Thus, our findings indicate that gigantol improves cholesterol and steroid biosynthesis within testicular Leydig cells." @default.
- W4200173896 created "2021-12-31" @default.
- W4200173896 creator A5006206942 @default.
- W4200173896 creator A5033888044 @default.
- W4200173896 creator A5050483054 @default.
- W4200173896 creator A5077764635 @default.
- W4200173896 date "2021-12-23" @default.
- W4200173896 modified "2023-10-13" @default.
- W4200173896 title "Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells" @default.
- W4200173896 cites W1567604126 @default.
- W4200173896 cites W1910811055 @default.
- W4200173896 cites W1974103027 @default.
- W4200173896 cites W1974917609 @default.
- W4200173896 cites W1979021117 @default.
- W4200173896 cites W1985213868 @default.
- W4200173896 cites W1985937024 @default.
- W4200173896 cites W1986735380 @default.
- W4200173896 cites W1990095295 @default.
- W4200173896 cites W2005542025 @default.
- W4200173896 cites W2007850244 @default.
- W4200173896 cites W2015577182 @default.
- W4200173896 cites W2024375221 @default.
- W4200173896 cites W2027687886 @default.
- W4200173896 cites W2036535656 @default.
- W4200173896 cites W2039490460 @default.
- W4200173896 cites W2046630350 @default.
- W4200173896 cites W2049566660 @default.
- W4200173896 cites W2054033355 @default.
- W4200173896 cites W2054854788 @default.
- W4200173896 cites W2056752882 @default.
- W4200173896 cites W2058645214 @default.
- W4200173896 cites W2060346337 @default.
- W4200173896 cites W2064934206 @default.
- W4200173896 cites W2074919560 @default.
- W4200173896 cites W2075912694 @default.
- W4200173896 cites W2076255703 @default.
- W4200173896 cites W2080023483 @default.
- W4200173896 cites W2081975982 @default.
- W4200173896 cites W2114728551 @default.
- W4200173896 cites W2122809114 @default.
- W4200173896 cites W2128635872 @default.
- W4200173896 cites W2130410032 @default.
- W4200173896 cites W2138207763 @default.
- W4200173896 cites W2151600299 @default.
- W4200173896 cites W2156030059 @default.
- W4200173896 cites W2165101701 @default.
- W4200173896 cites W2169456326 @default.
- W4200173896 cites W2179438025 @default.
- W4200173896 cites W2200701933 @default.
- W4200173896 cites W2231846049 @default.
- W4200173896 cites W2525211835 @default.
- W4200173896 cites W2594293541 @default.
- W4200173896 cites W2609758816 @default.
- W4200173896 cites W2731915316 @default.
- W4200173896 cites W2737852119 @default.
- W4200173896 cites W2754930359 @default.
- W4200173896 cites W2787259202 @default.
- W4200173896 cites W2790186760 @default.
- W4200173896 cites W2806444128 @default.
- W4200173896 cites W2902607016 @default.
- W4200173896 cites W2918086501 @default.
- W4200173896 cites W2944545583 @default.
- W4200173896 cites W2950580762 @default.
- W4200173896 cites W2953462222 @default.
- W4200173896 cites W2965216369 @default.
- W4200173896 cites W3010953141 @default.
- W4200173896 cites W3042842412 @default.
- W4200173896 cites W3137569079 @default.
- W4200173896 cites W3202852931 @default.
- W4200173896 cites W4293247451 @default.
- W4200173896 cites W748304302 @default.
- W4200173896 doi "https://doi.org/10.3390/cimb44010006" @default.
- W4200173896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35723385" @default.
- W4200173896 hasPublicationYear "2021" @default.
- W4200173896 type Work @default.
- W4200173896 citedByCount "6" @default.
- W4200173896 countsByYear W42001738962022 @default.
- W4200173896 countsByYear W42001738962023 @default.
- W4200173896 crossrefType "journal-article" @default.
- W4200173896 hasAuthorship W4200173896A5006206942 @default.
- W4200173896 hasAuthorship W4200173896A5033888044 @default.
- W4200173896 hasAuthorship W4200173896A5050483054 @default.
- W4200173896 hasAuthorship W4200173896A5077764635 @default.
- W4200173896 hasBestOaLocation W42001738961 @default.
- W4200173896 hasConcept C104317684 @default.
- W4200173896 hasConcept C126322002 @default.
- W4200173896 hasConcept C134018914 @default.
- W4200173896 hasConcept C185592680 @default.
- W4200173896 hasConcept C2777736315 @default.
- W4200173896 hasConcept C2778575703 @default.
- W4200173896 hasConcept C2779279991 @default.
- W4200173896 hasConcept C2780213334 @default.
- W4200173896 hasConcept C2780902042 @default.
- W4200173896 hasConcept C3020590458 @default.
- W4200173896 hasConcept C526171541 @default.
- W4200173896 hasConcept C553450214 @default.
- W4200173896 hasConcept C55493867 @default.
- W4200173896 hasConcept C62231903 @default.