FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200175655> ?p ?o ?g. }

• W4200175655 abstract "During dendritic cell (DC) development, Myc expression in progenitors is replaced by Mycl in mature DCs, but when and how this transition occurs is unknown. We evaluated DC development using reporters for MYC, MYCL, and cell cycle proteins Geminin and CDT1 in wild-type and various mutant mice. For classical type 1 dendritic cells (cDC1s) and plasmacytoid DCs (pDCs), the transition occurred upon their initial specification from common dendritic cell progenitors (CDPs) or common lymphoid progenitors (CLPs), respectively. This transition required high levels of IRF8 and interaction with PU.1, suggesting the use of EICEs within Mycl enhancers. In pDCs, maximal MYCL induction also required the +41kb Irf8 enhancer that controls pDC IRF8 expression. IRF8 also contributed to repression of MYC. While MYC is expressed only in rapidly dividing DC progenitors, MYCL is most highly expressed in DCs that have exited the cell cycle. Thus, IRF8 levels coordinate the Myc-Mycl transition during DC development." @default.
• W4200175655 created "2021-12-31" @default.
• W4200175655 creator A5036191257 @default.
• W4200175655 creator A5039642882 @default.
• W4200175655 creator A5069223250 @default.
• W4200175655 creator A5090464003 @default.
• W4200175655 date "2021-12-27" @default.
• W4200175655 modified "2023-10-12" @default.
• W4200175655 title "Transition from <i>cMyc</i> to <i>L-Myc</i> during dendritic cell development coordinated by rising levels of IRF8" @default.
• W4200175655 cites W1533862883 @default.
• W4200175655 cites W1742769645 @default.
• W4200175655 cites W1964891290 @default.
• W4200175655 cites W1989461823 @default.
• W4200175655 cites W2001042507 @default.
• W4200175655 cites W2004603629 @default.
• W4200175655 cites W2007037927 @default.
• W4200175655 cites W2008782348 @default.
• W4200175655 cites W2012571305 @default.
• W4200175655 cites W2014035331 @default.
• W4200175655 cites W2021340905 @default.
• W4200175655 cites W2034949556 @default.
• W4200175655 cites W2035041510 @default.
• W4200175655 cites W2037090825 @default.
• W4200175655 cites W2048768497 @default.
• W4200175655 cites W2048793063 @default.
• W4200175655 cites W2051008724 @default.
• W4200175655 cites W2054581136 @default.
• W4200175655 cites W2055192078 @default.
• W4200175655 cites W2056461632 @default.
• W4200175655 cites W2065085347 @default.
• W4200175655 cites W2065391646 @default.
• W4200175655 cites W2083659467 @default.
• W4200175655 cites W2083798679 @default.
• W4200175655 cites W2089500151 @default.
• W4200175655 cites W2094504570 @default.
• W4200175655 cites W2111435630 @default.
• W4200175655 cites W2128936341 @default.
• W4200175655 cites W2139683904 @default.
• W4200175655 cites W2140300773 @default.
• W4200175655 cites W2146996213 @default.
• W4200175655 cites W2151369808 @default.
• W4200175655 cites W2152414109 @default.
• W4200175655 cites W2157009395 @default.
• W4200175655 cites W2172033467 @default.
• W4200175655 cites W2207263671 @default.
• W4200175655 cites W2510595980 @default.
• W4200175655 cites W2519385241 @default.
• W4200175655 cites W2524106150 @default.
• W4200175655 cites W2557697030 @default.
• W4200175655 cites W2611696724 @default.
• W4200175655 cites W2783692764 @default.
• W4200175655 cites W2808957884 @default.
• W4200175655 cites W2949323419 @default.
• W4200175655 cites W2961156677 @default.
• W4200175655 cites W2967647113 @default.
• W4200175655 cites W2968141004 @default.
• W4200175655 cites W2971790873 @default.
• W4200175655 cites W3006682883 @default.
• W4200175655 cites W3018353191 @default.
• W4200175655 cites W3048756957 @default.
• W4200175655 cites W3084001151 @default.
• W4200175655 doi "https://doi.org/10.1084/jem.20211483" @default.
• W4200175655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34958351" @default.
• W4200175655 hasPublicationYear "2021" @default.
• W4200175655 type Work @default.
• W4200175655 citedByCount "10" @default.
• W4200175655 countsByYear W42001756552022 @default.
• W4200175655 countsByYear W42001756552023 @default.
• W4200175655 crossrefType "journal-article" @default.
• W4200175655 hasAuthorship W4200175655A5036191257 @default.
• W4200175655 hasAuthorship W4200175655A5039642882 @default.
• W4200175655 hasAuthorship W4200175655A5069223250 @default.
• W4200175655 hasAuthorship W4200175655A5090464003 @default.
• W4200175655 hasBestOaLocation W42001756551 @default.
• W4200175655 hasConcept C104317684 @default.
• W4200175655 hasConcept C111936080 @default.
• W4200175655 hasConcept C117705580 @default.
• W4200175655 hasConcept C201750760 @default.
• W4200175655 hasConcept C203014093 @default.
• W4200175655 hasConcept C2778170410 @default.
• W4200175655 hasConcept C28328180 @default.
• W4200175655 hasConcept C54355233 @default.
• W4200175655 hasConcept C79904392 @default.
• W4200175655 hasConcept C86339819 @default.
• W4200175655 hasConcept C86803240 @default.
• W4200175655 hasConcept C8891405 @default.
• W4200175655 hasConcept C95444343 @default.
• W4200175655 hasConceptScore W4200175655C104317684 @default.
• W4200175655 hasConceptScore W4200175655C111936080 @default.
• W4200175655 hasConceptScore W4200175655C117705580 @default.
• W4200175655 hasConceptScore W4200175655C201750760 @default.
• W4200175655 hasConceptScore W4200175655C203014093 @default.
• W4200175655 hasConceptScore W4200175655C2778170410 @default.
• W4200175655 hasConceptScore W4200175655C28328180 @default.
• W4200175655 hasConceptScore W4200175655C54355233 @default.
• W4200175655 hasConceptScore W4200175655C79904392 @default.
• W4200175655 hasConceptScore W4200175655C86339819 @default.
• W4200175655 hasConceptScore W4200175655C86803240 @default.
• W4200175655 hasConceptScore W4200175655C8891405 @default.
• W4200175655 hasConceptScore W4200175655C95444343 @default.

• next