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• W4200177639 abstract "The well-known toxic medicine Gelsemium elegans is widely and historically used to treat bone fracture and skin ulcers by the folk people of China. Two new monoterpenoid indole alkaloids, gelselegandines D and E, together with the known analogue gelegamine A were isolated from G. elegans. Their structures were elucidated by means of spectroscopic techniques and quantum chemical calculations. All isolated compounds were tested for the effects on RANKL-induced osteoclast formation. Interestingly, gelselegandine E and gelegamine A, respectively, showed significant promoting and inhibitory activities on osteoclastogenesis, while gelselegandine D had no activity under the same concentration. This work suggested the different configurations for the carbons near the C-19/20 oxygen rings of the isolated compounds may be the key active groups on osteoclast formation and provided the evidence for the rationality as the traditional treatment for bone-related diseases of G. elegans." @default.
• W4200177639 created "2021-12-31" @default.
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• W4200177639 date "2021-12-09" @default.
• W4200177639 modified "2023-09-24" @default.
• W4200177639 title "New Monoterpenoid Indoles with Osteoclast Activities from Gelsemium elegans" @default.
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• W4200177639 doi "https://doi.org/10.3390/molecules26247457" @default.
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