FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200179014> ?p ?o ?g. }

• W4200179014 abstract "Renal cell carcinoma (RCC) represents 2.2% of all cancer incidences; however, prognostic or predictive RCC biomarkers at protein level are largely missing. To support proteomics research of localized and metastatic RCC, we introduce a new library of targeted mass spectrometry assays for accurate protein quantification in malignant and normal kidney tissue. Aliquots of 86 initially localized RCC, 75 metastatic RCC and 17 adjacent non-cancerous fresh frozen tissue lysates were trypsin digested, pooled, and fractionated using hydrophilic chromatography. The fractions were analyzed using LC-MS/MS on QExactive HF-X mass spectrometer in data-dependent acquisition (DDA) mode. A resulting spectral library contains 77,817 peptides representing 7960 protein groups (FDR = 1%). Further, we confirm applicability of this library on four RCC datasets measured in data-independent acquisition (DIA) mode, demonstrating a specific quantification of a substantially increased part of RCC proteome, depending on LC-MS/MS instrumentation. Impact of sample specificity of the library on the results of targeted DIA data extraction was demonstrated by parallel analyses of two datasets by two pan human libraries. The new RCC specific library has potential to contribute to better understanding the RCC development at molecular level, leading to new diagnostic and therapeutic targets." @default.
• W4200179014 created "2021-12-31" @default.
• W4200179014 creator A5006324943 @default.
• W4200179014 creator A5008870382 @default.
• W4200179014 creator A5011327653 @default.
• W4200179014 creator A5017254781 @default.
• W4200179014 creator A5017367590 @default.
• W4200179014 creator A5069592985 @default.
• W4200179014 creator A5072614457 @default.
• W4200179014 creator A5082994579 @default.
• W4200179014 creator A5088540019 @default.
• W4200179014 date "2021-12-22" @default.
• W4200179014 modified "2023-10-06" @default.
• W4200179014 title "A large‐scale assay library for targeted protein quantification in renal cell carcinoma tissues" @default.
• W4200179014 cites W1509042831 @default.
• W4200179014 cites W1896930635 @default.
• W4200179014 cites W2027222148 @default.
• W4200179014 cites W2033047611 @default.
• W4200179014 cites W2045117578 @default.
• W4200179014 cites W2058206747 @default.
• W4200179014 cites W2069480574 @default.
• W4200179014 cites W2098364431 @default.
• W4200179014 cites W2099752220 @default.
• W4200179014 cites W2100584122 @default.
• W4200179014 cites W2115927224 @default.
• W4200179014 cites W2143813821 @default.
• W4200179014 cites W2314894294 @default.
• W4200179014 cites W2478131123 @default.
• W4200179014 cites W2580819151 @default.
• W4200179014 cites W2581896965 @default.
• W4200179014 cites W2745376284 @default.
• W4200179014 cites W2887294942 @default.
• W4200179014 cites W2914074147 @default.
• W4200179014 cites W2957606438 @default.
• W4200179014 cites W2984906251 @default.
• W4200179014 cites W3015356575 @default.
• W4200179014 cites W3048365909 @default.
• W4200179014 cites W3128646645 @default.
• W4200179014 cites W3196816601 @default.
• W4200179014 cites W4255387133 @default.
• W4200179014 doi "https://doi.org/10.1002/pmic.202100228" @default.
• W4200179014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34902229" @default.
• W4200179014 hasPublicationYear "2021" @default.
• W4200179014 type Work @default.
• W4200179014 citedByCount "0" @default.
• W4200179014 crossrefType "journal-article" @default.
• W4200179014 hasAuthorship W4200179014A5006324943 @default.
• W4200179014 hasAuthorship W4200179014A5008870382 @default.
• W4200179014 hasAuthorship W4200179014A5011327653 @default.
• W4200179014 hasAuthorship W4200179014A5017254781 @default.
• W4200179014 hasAuthorship W4200179014A5017367590 @default.
• W4200179014 hasAuthorship W4200179014A5069592985 @default.
• W4200179014 hasAuthorship W4200179014A5072614457 @default.
• W4200179014 hasAuthorship W4200179014A5082994579 @default.
• W4200179014 hasAuthorship W4200179014A5088540019 @default.
• W4200179014 hasBestOaLocation W42001790142 @default.
• W4200179014 hasConcept C104317684 @default.
• W4200179014 hasConcept C104397665 @default.
• W4200179014 hasConcept C143998085 @default.
• W4200179014 hasConcept C162356407 @default.
• W4200179014 hasConcept C185592680 @default.
• W4200179014 hasConcept C2777472916 @default.
• W4200179014 hasConcept C43617362 @default.
• W4200179014 hasConcept C46111723 @default.
• W4200179014 hasConcept C55493867 @default.
• W4200179014 hasConcept C60644358 @default.
• W4200179014 hasConcept C70721500 @default.
• W4200179014 hasConcept C71924100 @default.
• W4200179014 hasConcept C86803240 @default.
• W4200179014 hasConceptScore W4200179014C104317684 @default.
• W4200179014 hasConceptScore W4200179014C104397665 @default.
• W4200179014 hasConceptScore W4200179014C143998085 @default.
• W4200179014 hasConceptScore W4200179014C162356407 @default.
• W4200179014 hasConceptScore W4200179014C185592680 @default.
• W4200179014 hasConceptScore W4200179014C2777472916 @default.
• W4200179014 hasConceptScore W4200179014C43617362 @default.
• W4200179014 hasConceptScore W4200179014C46111723 @default.
• W4200179014 hasConceptScore W4200179014C55493867 @default.
• W4200179014 hasConceptScore W4200179014C60644358 @default.
• W4200179014 hasConceptScore W4200179014C70721500 @default.
• W4200179014 hasConceptScore W4200179014C71924100 @default.
• W4200179014 hasConceptScore W4200179014C86803240 @default.
• W4200179014 hasIssue "7" @default.
• W4200179014 hasLocation W42001790141 @default.
• W4200179014 hasLocation W42001790142 @default.
• W4200179014 hasLocation W42001790143 @default.
• W4200179014 hasOpenAccess W4200179014 @default.
• W4200179014 hasPrimaryLocation W42001790141 @default.
• W4200179014 hasRelatedWork W1614434693 @default.
• W4200179014 hasRelatedWork W2050333409 @default.
• W4200179014 hasRelatedWork W2080856312 @default.
• W4200179014 hasRelatedWork W2086860678 @default.
• W4200179014 hasRelatedWork W2088324202 @default.
• W4200179014 hasRelatedWork W2109364024 @default.
• W4200179014 hasRelatedWork W2122805769 @default.
• W4200179014 hasRelatedWork W2165553666 @default.
• W4200179014 hasRelatedWork W2337002289 @default.
• W4200179014 hasRelatedWork W3187594710 @default.
• W4200179014 hasVolume "22" @default.
• W4200179014 isParatext "false" @default.

• next