Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200180497> ?p ?o ?g. }
- W4200180497 abstract "Abstract The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has now reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness." @default.
- W4200180497 created "2021-12-31" @default.
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- W4200180497 date "2021-12-07" @default.
- W4200180497 modified "2023-10-15" @default.
- W4200180497 title "The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: the case of the spike A222V mutation" @default.
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- W4200180497 doi "https://doi.org/10.1101/2021.12.05.471263" @default.
- W4200180497 hasPublicationYear "2021" @default.