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- W4200183749 abstract "Abstract Developing bio-pesticides is an important area of research in agriculture for which viruses are an essential tool. Infection by entomological pathogenic viruses kills agricultural pests, and viral progenies are disseminated to infect more pests, eventually achieving long-term pest control in the field. Of the current virus-based pest control models, Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the most studied. AcMNPV belongs to the family Baculoviridae and can infect many lepidopterans. Although AcMNPV has been previously demonstrated as a potential pest-control tool, its long virus infection cycle has made field application challenging. To overcome this hurdle, we generated a recombinant baculovirus that can express mammalian galectin-1, which is a-galactoside-binding protein that binds to the peritrophic matrix in the midgut of pest lepidopterans and induces perforation of the membrane. Galectin-1 has been shown to affect immune responses in mammals, including humans, but to our knowledge, the effect of galectin-1 on insect immune systems has not been previously reported. Hosts infected with this recombinant virus exhibited reduced appetite and died sooner in both laboratory and small-scale field studies, suggesting that the overexpression of galectin-1 can more efficiently eliminate pest hosts. In addition to disrupting the integrity of the peritrophic matrix, the immune system of hosts infected with recombinant baculovirus carrying the galectin-1 gene was suppressed, making hosts more vulnerable to secondary infection. These results demonstrated that the potential of baculovirus for pest control can be improved by using a recombinant baculovirus that overexpresses mammalian galectin-1 in hosts." @default.
- W4200183749 created "2021-12-31" @default.
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- W4200183749 date "2021-11-16" @default.
- W4200183749 modified "2023-09-26" @default.
- W4200183749 title "Enhancing the Insecticidal Potential of Baculovirus by Overexpressing the Mammalian Β-Galactosyl Binding Protein Galectin-1" @default.
- W4200183749 doi "https://doi.org/10.21203/rs.3.rs-889675/v1" @default.
- W4200183749 hasPublicationYear "2021" @default.
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