Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200183989> ?p ?o ?g. }
- W4200183989 abstract "ABSTRACT Polycomb Repressive Complexes 1 and 2 (PRC1, PRC2) are conserved epigenetic regulators that promote transcriptional silencing. PRC1 and PRC2 converge on shared targets, catalyzing repressive histone modifications. In addition, a subset of PRC1/PRC2 targets engage in long-range interactions whose functions in gene silencing are poorly understood. Using a CRISPR screen in mouse embryonic stem cells, we identified that the cohesin regulator PDS5A links transcriptional silencing by Polycomb and 3D genome organization. PDS5A deletion impairs cohesin unloading and results in derepression of subset of endogenous PRC1/PRC2 target genes. Importantly, derepression is not associated with loss of repressive Polycomb chromatin modifications. Instead, loss of PDS5A leads to aberrant cohesin activity, ectopic insulation sites and specific reduction of ultra-long Polycomb loops. We infer that these loops are important for robust silencing at a subset of Polycomb target genes and that maintenance of cohesin-dependent genome architecture is critical for Polycomb regulation." @default.
- W4200183989 created "2021-12-31" @default.
- W4200183989 creator A5008763267 @default.
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- W4200183989 creator A5034160855 @default.
- W4200183989 creator A5039207382 @default.
- W4200183989 creator A5076096435 @default.
- W4200183989 date "2021-12-16" @default.
- W4200183989 modified "2023-10-16" @default.
- W4200183989 title "Loss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops" @default.
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