FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200184435> ?p ?o ?g. }

• W4200184435 endingPage "2545" @default.
• W4200184435 startingPage "2545" @default.
• W4200184435 abstract "SARS-CoV-2 infection in pregnant women can lead to placental damage and transplacental infection transfer, and intrauterine fetal demise is an unpredictable event.A 32-year-old patient in her 38th week of pregnancy reported loss of fetal movements. She overcame mild COVID-19 with positive PCR test 22 days before. A histology of the placenta showed deposition of intervillous fibrinoid, lympho-histiocytic infiltration, scant neutrophils, clumping of villi, and extant infarctions. Immunohistochemistry identified focal SARS-CoV-2 nucleocapsid and spike protein in the syncytiotrophoblast and isolated in situ hybridization of the virus' RNA. Low ACE2 and TMPRSS2 contrasted with strong basigin/CD147 and PDL-1 positivity in the trophoblast. An autopsy of the fetus showed no morphological abnormalities except for lung interstitial infiltrate, with prevalent CD8-positive T-lymphocytes and B-lymphocytes. Immunohistochemistry and in situ hybridization proved the presence of countless dispersed SARS-CoV-2-infected epithelial and endothelial cells in the lung tissue. The potential virus-receptor protein ACE2, TMPRSS2, and CD147 expression was too low to be detected.Over three weeks' persistence of trophoblast viral infection lead to extensive intervillous fibrinoid depositions and placental infarctions. High CD147 expression might serve as the dominant receptor for the virus, and PDL-1 could limit maternal immunity in placental tissue virus clearance. The presented case indicates that the SARS-CoV-2 infection-induced changes in the placenta lead to ischemia and consecutive demise of the fetus. The infection of the fetus was without significant impact on its death. This rare complication of pregnancy can appear independently to the severity of COVID-19's clinical course in the pregnant mother." @default.
• W4200184435 created "2021-12-31" @default.
• W4200184435 creator A5006323252 @default.
• W4200184435 creator A5021454804 @default.
• W4200184435 creator A5037755351 @default.
• W4200184435 creator A5053102900 @default.
• W4200184435 creator A5054560912 @default.
• W4200184435 creator A5057337617 @default.
• W4200184435 creator A5080934987 @default.
• W4200184435 creator A5084784513 @default.
• W4200184435 creator A5085593232 @default.
• W4200184435 date "2021-12-19" @default.
• W4200184435 modified "2023-10-18" @default.
• W4200184435 title "Intrauterine Fetal Demise After Uncomplicated COVID-19: What Can We Learn from the Case?" @default.
• W4200184435 cites W3010182902 @default.
• W4200184435 cites W3010323736 @default.
• W4200184435 cites W3022435472 @default.
• W4200184435 cites W3025423046 @default.
• W4200184435 cites W3036535913 @default.
• W4200184435 cites W3041567674 @default.
• W4200184435 cites W3041960287 @default.
• W4200184435 cites W3046727752 @default.
• W4200184435 cites W3049119183 @default.
• W4200184435 cites W3081902484 @default.
• W4200184435 cites W3087697729 @default.
• W4200184435 cites W3090792916 @default.
• W4200184435 cites W3107235131 @default.
• W4200184435 cites W3108906525 @default.
• W4200184435 cites W3113168864 @default.
• W4200184435 cites W3117649460 @default.
• W4200184435 cites W3121669581 @default.
• W4200184435 cites W3126427147 @default.
• W4200184435 cites W3158425414 @default.
• W4200184435 cites W3162447882 @default.
• W4200184435 cites W3164204322 @default.
• W4200184435 cites W3167986932 @default.
• W4200184435 cites W3177835915 @default.
• W4200184435 cites W3188083250 @default.
• W4200184435 cites W3190556842 @default.
• W4200184435 cites W3196267730 @default.
• W4200184435 cites W3211046455 @default.
• W4200184435 cites W4206399221 @default.
• W4200184435 cites W4206812716 @default.
• W4200184435 doi "https://doi.org/10.3390/v13122545" @default.
• W4200184435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34960815" @default.
• W4200184435 hasPublicationYear "2021" @default.
• W4200184435 type Work @default.
• W4200184435 citedByCount "15" @default.
• W4200184435 countsByYear W42001844352022 @default.
• W4200184435 countsByYear W42001844352023 @default.
• W4200184435 crossrefType "journal-article" @default.
• W4200184435 hasAuthorship W4200184435A5006323252 @default.
• W4200184435 hasAuthorship W4200184435A5021454804 @default.
• W4200184435 hasAuthorship W4200184435A5037755351 @default.
• W4200184435 hasAuthorship W4200184435A5053102900 @default.
• W4200184435 hasAuthorship W4200184435A5054560912 @default.
• W4200184435 hasAuthorship W4200184435A5057337617 @default.
• W4200184435 hasAuthorship W4200184435A5080934987 @default.
• W4200184435 hasAuthorship W4200184435A5084784513 @default.
• W4200184435 hasAuthorship W4200184435A5085593232 @default.
• W4200184435 hasBestOaLocation W42001844351 @default.
• W4200184435 hasConcept C104317684 @default.
• W4200184435 hasConcept C126322002 @default.
• W4200184435 hasConcept C142724271 @default.
• W4200184435 hasConcept C150194340 @default.
• W4200184435 hasConcept C16685009 @default.
• W4200184435 hasConcept C172680121 @default.
• W4200184435 hasConcept C203014093 @default.
• W4200184435 hasConcept C204232928 @default.
• W4200184435 hasConcept C2776953305 @default.
• W4200184435 hasConcept C2777495146 @default.
• W4200184435 hasConcept C2777714996 @default.
• W4200184435 hasConcept C2779234561 @default.
• W4200184435 hasConcept C2779315647 @default.
• W4200184435 hasConcept C2779906218 @default.
• W4200184435 hasConcept C2780197806 @default.
• W4200184435 hasConcept C54355233 @default.
• W4200184435 hasConcept C55493867 @default.
• W4200184435 hasConcept C71924100 @default.
• W4200184435 hasConcept C81439078 @default.
• W4200184435 hasConcept C86803240 @default.
• W4200184435 hasConceptScore W4200184435C104317684 @default.
• W4200184435 hasConceptScore W4200184435C126322002 @default.
• W4200184435 hasConceptScore W4200184435C142724271 @default.
• W4200184435 hasConceptScore W4200184435C150194340 @default.
• W4200184435 hasConceptScore W4200184435C16685009 @default.
• W4200184435 hasConceptScore W4200184435C172680121 @default.
• W4200184435 hasConceptScore W4200184435C203014093 @default.
• W4200184435 hasConceptScore W4200184435C204232928 @default.
• W4200184435 hasConceptScore W4200184435C2776953305 @default.
• W4200184435 hasConceptScore W4200184435C2777495146 @default.
• W4200184435 hasConceptScore W4200184435C2777714996 @default.
• W4200184435 hasConceptScore W4200184435C2779234561 @default.
• W4200184435 hasConceptScore W4200184435C2779315647 @default.
• W4200184435 hasConceptScore W4200184435C2779906218 @default.
• W4200184435 hasConceptScore W4200184435C2780197806 @default.
• W4200184435 hasConceptScore W4200184435C54355233 @default.
• W4200184435 hasConceptScore W4200184435C55493867 @default.

• next