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- W4200192012 abstract "The risks associated with fetal growth restriction (FGR) and small for gestational age (SGA) neonates are significant, and identifying fetuses at risk for development of FGR and SGA is critical. We examine the association and predictive value of isolated short femur length at 20 week anatomic survey with third trimester FGR and SGA at birth. This is a retrospective cohort study of 7,209 anatomic (76805 and 76811) ultrasounds performed in a single academic center between 1/1/16 and 05/01/21, excluding multiple gestations. These patients were matched with their 28 week and 32 week growth ultrasounds and delivery data. A total of 1,402 women were included with all three ultrasounds. We created ROC curves for the ability of isolated femur length (FL) less than the 5th and 10th percentile at 20 weeks to predict FGR at 28 weeks, 32 weeks, or SGA at delivery (defined as less than 10th percentile on the Fenton curve for newborns). Logistic regression was performed to adjust for confounding variables. FL < 10th percentile was significantly associated with an increased odds of FGR at 28 (OR 72.3 [95% CI 20.37-256.42]) and 32 weeks (OR 30.5 [95% CI 10.54-88.31]). This remained significant when controlling for race. A similar association was found with FL < 5th percentile. FL less than the 10th percentile was also associated with an increased risk of SGA at birth (aOR 4.41 [95% CI 1.91-10.2]). However, neither isolated FL < 5th or 10th percentile at 20 weeks was predictive of FGR at 28 or 32 weeks or SGA, with no single AUC greater than 0.57. Isolated FL < 10th percentile does appear to be associated with FGR at both 28 and 32 week ultrasounds and SGA at birth. However, the predictive value of an isolated short femur length at 20 weeks for third-trimester FGR or SGA is poor, and these data suggest that this finding alone may not be reason to obtain serial growth ultrasounds.View Large Image Figure ViewerDownload Hi-res image Download (PPT)" @default.
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- W4200192012 date "2022-01-01" @default.
- W4200192012 modified "2023-09-27" @default.
- W4200192012 title "Is an isolated short femur an indication for growth ultrasounds?" @default.
- W4200192012 doi "https://doi.org/10.1016/j.ajog.2021.11.809" @default.
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