Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200193313> ?p ?o ?g. }
- W4200193313 abstract "The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration." @default.
- W4200193313 created "2021-12-31" @default.
- W4200193313 creator A5018336428 @default.
- W4200193313 creator A5052430596 @default.
- W4200193313 creator A5061791905 @default.
- W4200193313 creator A5082223385 @default.
- W4200193313 date "2021-12-16" @default.
- W4200193313 modified "2023-09-28" @default.
- W4200193313 title "Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells" @default.
- W4200193313 cites W1508177354 @default.
- W4200193313 cites W1533287311 @default.
- W4200193313 cites W1558100964 @default.
- W4200193313 cites W1570206060 @default.
- W4200193313 cites W1594840853 @default.
- W4200193313 cites W1661544713 @default.
- W4200193313 cites W1776803469 @default.
- W4200193313 cites W1920486352 @default.
- W4200193313 cites W1926141441 @default.
- W4200193313 cites W1966400897 @default.
- W4200193313 cites W1971084572 @default.
- W4200193313 cites W1971405375 @default.
- W4200193313 cites W1983865000 @default.
- W4200193313 cites W1985420026 @default.
- W4200193313 cites W1987062630 @default.
- W4200193313 cites W1989376817 @default.
- W4200193313 cites W1991271525 @default.
- W4200193313 cites W1995692886 @default.
- W4200193313 cites W1997602206 @default.
- W4200193313 cites W1999720993 @default.
- W4200193313 cites W2000365029 @default.
- W4200193313 cites W2008436201 @default.
- W4200193313 cites W2010840514 @default.
- W4200193313 cites W2012136117 @default.
- W4200193313 cites W2015130930 @default.
- W4200193313 cites W2015738975 @default.
- W4200193313 cites W2016224591 @default.
- W4200193313 cites W2017443735 @default.
- W4200193313 cites W2024160645 @default.
- W4200193313 cites W2026409879 @default.
- W4200193313 cites W2029022613 @default.
- W4200193313 cites W2034643457 @default.
- W4200193313 cites W2036716507 @default.
- W4200193313 cites W2040196938 @default.
- W4200193313 cites W2042020095 @default.
- W4200193313 cites W2042906495 @default.
- W4200193313 cites W2043713627 @default.
- W4200193313 cites W2047575104 @default.
- W4200193313 cites W2055132644 @default.
- W4200193313 cites W2056414701 @default.
- W4200193313 cites W2061390876 @default.
- W4200193313 cites W2064208720 @default.
- W4200193313 cites W2069184106 @default.
- W4200193313 cites W2071998818 @default.
- W4200193313 cites W2072032391 @default.
- W4200193313 cites W2081196609 @default.
- W4200193313 cites W2085780740 @default.
- W4200193313 cites W2098745262 @default.
- W4200193313 cites W2101099943 @default.
- W4200193313 cites W2101235551 @default.
- W4200193313 cites W2104082830 @default.
- W4200193313 cites W2107413005 @default.
- W4200193313 cites W2117781731 @default.
- W4200193313 cites W2122828560 @default.
- W4200193313 cites W2127964443 @default.
- W4200193313 cites W2128291544 @default.
- W4200193313 cites W2137481116 @default.
- W4200193313 cites W2138011817 @default.
- W4200193313 cites W2139812868 @default.
- W4200193313 cites W2141570700 @default.
- W4200193313 cites W2143622218 @default.
- W4200193313 cites W2145725478 @default.
- W4200193313 cites W2146355265 @default.
- W4200193313 cites W2149254479 @default.
- W4200193313 cites W2158500407 @default.
- W4200193313 cites W2159193579 @default.
- W4200193313 cites W2166786675 @default.
- W4200193313 cites W2167218320 @default.
- W4200193313 cites W2176490156 @default.
- W4200193313 cites W2261563054 @default.
- W4200193313 cites W2292051166 @default.
- W4200193313 cites W2303653884 @default.
- W4200193313 cites W2338188328 @default.
- W4200193313 cites W2396720780 @default.
- W4200193313 cites W2506243926 @default.
- W4200193313 cites W2507799633 @default.
- W4200193313 cites W2512726762 @default.
- W4200193313 cites W2559713904 @default.
- W4200193313 cites W2562443541 @default.
- W4200193313 cites W2568937021 @default.
- W4200193313 cites W2605014235 @default.
- W4200193313 cites W2606121309 @default.
- W4200193313 cites W2607819139 @default.
- W4200193313 cites W2701106679 @default.
- W4200193313 cites W2758699621 @default.
- W4200193313 cites W2765955845 @default.
- W4200193313 cites W2767292675 @default.
- W4200193313 cites W2770411123 @default.
- W4200193313 cites W2772851675 @default.
- W4200193313 cites W2791291647 @default.
- W4200193313 cites W2796542284 @default.