Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200193443> ?p ?o ?g. }
- W4200193443 endingPage "6214" @default.
- W4200193443 startingPage "6214" @default.
- W4200193443 abstract "Cell cycle progression is an elaborate process that requires stringent control for normal cellular function. Defects in cell cycle control, however, contribute to genomic instability and have become a characteristic phenomenon in cancers. Over the years, advancement in the understanding of disrupted cell cycle regulation in tumors has led to the development of powerful anti-cancer drugs. Therefore, an in-depth exploration of cell cycle dysregulation in cancers could provide therapeutic avenues for cancer treatment. The Hippo pathway is an evolutionarily conserved regulator network that controls organ size, and its dysregulation is implicated in various types of cancers. Although the role of the Hippo pathway in oncogenesis has been widely investigated, its role in cell cycle regulation has not been comprehensively scrutinized. Here, we specifically focus on delineating the involvement of the Hippo pathway in cell cycle regulation. To that end, we first compare the structural as well as functional conservation of the core Hippo pathway in yeasts, flies, and mammals. Then, we detail the multi-faceted aspects in which the core components of the mammalian Hippo pathway and their regulators affect the cell cycle, particularly with regard to the regulation of E2F activity, the G1 tetraploidy checkpoint, DNA synthesis, DNA damage checkpoint, centrosome dynamics, and mitosis. Finally, we briefly discuss how a collective understanding of cell cycle regulation and the Hippo pathway could be weaponized in combating cancer." @default.
- W4200193443 created "2021-12-31" @default.
- W4200193443 creator A5027840612 @default.
- W4200193443 creator A5055324310 @default.
- W4200193443 date "2021-12-10" @default.
- W4200193443 modified "2023-10-16" @default.
- W4200193443 title "The Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective" @default.
- W4200193443 cites W1171415056 @default.
- W4200193443 cites W1493317669 @default.
- W4200193443 cites W1494264400 @default.
- W4200193443 cites W1542760571 @default.
- W4200193443 cites W1544564404 @default.
- W4200193443 cites W1633738151 @default.
- W4200193443 cites W1635667563 @default.
- W4200193443 cites W1886278373 @default.
- W4200193443 cites W1923908188 @default.
- W4200193443 cites W1963587413 @default.
- W4200193443 cites W1966928239 @default.
- W4200193443 cites W1967163876 @default.
- W4200193443 cites W1967477749 @default.
- W4200193443 cites W1968050352 @default.
- W4200193443 cites W1971801159 @default.
- W4200193443 cites W1974891320 @default.
- W4200193443 cites W1975489922 @default.
- W4200193443 cites W1976356130 @default.
- W4200193443 cites W1976990850 @default.
- W4200193443 cites W1978173004 @default.
- W4200193443 cites W1980044253 @default.
- W4200193443 cites W1981268203 @default.
- W4200193443 cites W1982474353 @default.
- W4200193443 cites W1983691421 @default.
- W4200193443 cites W1984283750 @default.
- W4200193443 cites W1986406749 @default.
- W4200193443 cites W1990291944 @default.
- W4200193443 cites W1993320949 @default.
- W4200193443 cites W1993341576 @default.
- W4200193443 cites W1993926535 @default.
- W4200193443 cites W1995493961 @default.
- W4200193443 cites W1995940145 @default.
- W4200193443 cites W1995987212 @default.
- W4200193443 cites W1997141458 @default.
- W4200193443 cites W1997719641 @default.
- W4200193443 cites W1998176022 @default.
- W4200193443 cites W1998781040 @default.
- W4200193443 cites W1998807331 @default.
- W4200193443 cites W1999077006 @default.
- W4200193443 cites W1999349518 @default.
- W4200193443 cites W2000662094 @default.
- W4200193443 cites W2002344928 @default.
- W4200193443 cites W2003044806 @default.
- W4200193443 cites W2004468028 @default.
- W4200193443 cites W2005073257 @default.
- W4200193443 cites W2006113261 @default.
- W4200193443 cites W2006763255 @default.
- W4200193443 cites W2008308460 @default.
- W4200193443 cites W2008920883 @default.
- W4200193443 cites W2009512217 @default.
- W4200193443 cites W2010050096 @default.
- W4200193443 cites W2010960430 @default.
- W4200193443 cites W2011188977 @default.
- W4200193443 cites W2013507063 @default.
- W4200193443 cites W2014601473 @default.
- W4200193443 cites W2015141765 @default.
- W4200193443 cites W2016672123 @default.
- W4200193443 cites W2018172401 @default.
- W4200193443 cites W2022423243 @default.
- W4200193443 cites W2023004298 @default.
- W4200193443 cites W2025190086 @default.
- W4200193443 cites W2029714022 @default.
- W4200193443 cites W2031198628 @default.
- W4200193443 cites W2032173458 @default.
- W4200193443 cites W2034059681 @default.
- W4200193443 cites W2036540085 @default.
- W4200193443 cites W2038441458 @default.
- W4200193443 cites W2040504060 @default.
- W4200193443 cites W2043051103 @default.
- W4200193443 cites W2046510113 @default.
- W4200193443 cites W2047521557 @default.
- W4200193443 cites W2047640173 @default.
- W4200193443 cites W2049651125 @default.
- W4200193443 cites W2051200214 @default.
- W4200193443 cites W2051420187 @default.
- W4200193443 cites W2053313103 @default.
- W4200193443 cites W2054699746 @default.
- W4200193443 cites W2054715006 @default.
- W4200193443 cites W2056102163 @default.
- W4200193443 cites W2056400898 @default.
- W4200193443 cites W2057355058 @default.
- W4200193443 cites W2057682511 @default.
- W4200193443 cites W2057825938 @default.
- W4200193443 cites W2058045448 @default.
- W4200193443 cites W2058376796 @default.
- W4200193443 cites W2058800151 @default.
- W4200193443 cites W2058813601 @default.
- W4200193443 cites W2060702837 @default.
- W4200193443 cites W2062184380 @default.
- W4200193443 cites W2062312677 @default.
- W4200193443 cites W2065398225 @default.