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- W4200194001 abstract "iNKT cells play a critical role in controlling the strength and character of adaptive and innate immune responses. Their unique functional characteristics are induced by a transcriptional program initiated by positive selection mediated by CD1d expressed by CD4+CD8+ (double positive, DP) thymocytes. Here, using a novel Vα14 TCR transgenic strain bearing greatly expanded numbers of CD24hiCD44loNKT cells, we examined transcriptional events in four immature thymic iNKT cell subsets. A transcriptional regulatory network approach identified transcriptional changes in proximal components of the TCR signalling cascade in DP NKT cells. Subsequently, positive and negative selection, and lineage commitment, occurred at the transition from DP NKT to CD4 NKT. Thus, this study introduces previously unrecognised steps in early NKT cell development, and separates the events associated with modulation of the T cell signalling cascade prior to changes associated with positive selection and lineage commitment." @default.
- W4200194001 created "2021-12-31" @default.
- W4200194001 creator A5000597095 @default.
- W4200194001 creator A5004494145 @default.
- W4200194001 creator A5018163670 @default.
- W4200194001 creator A5027645613 @default.
- W4200194001 creator A5054560533 @default.
- W4200194001 creator A5074555037 @default.
- W4200194001 creator A5078617215 @default.
- W4200194001 creator A5081485875 @default.
- W4200194001 date "2021-12-08" @default.
- W4200194001 modified "2023-10-06" @default.
- W4200194001 title "Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells" @default.
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