Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200194016> ?p ?o ?g. }
- W4200194016 endingPage "464" @default.
- W4200194016 startingPage "450" @default.
- W4200194016 abstract "Right ventricular (RV) dysfunction, pulmonary hypertension, and exercise intolerance have prognostic values, but their interrelation is not fully understood. We investigated how RV function alone and its coupling with pulmonary circulation (RV-PA) predict cardio-respiratory fitness in patients with heart failure and reduced ejection fraction (HFrEF).The Evaluation of Resynchronization Therapy for Heart Failure (EARTH) study included 205 HFrEF patients with narrow (n = 85) and prolonged (n = 120) QRS duration undergoing implantable cardioverter defibrillator implantation. All patients underwent a comprehensive evaluation with exercise tolerance tests and echocardiography. We investigated the correlations at baseline between RV parameters {size, function [tricuspid annular plane systolic excursion (TAPSE), RV fractional area change (RV-FAC), and RV myocardial performance index (RV-MPI)], pulmonary artery systolic pressure (PASP), and tricuspid regurgitation}; left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume index (LVEDVi), and left atrial volume index (LAVi); and cardiopulmonary exercise test (CPET) [peak VO2 , minute ventilation/carbon dioxide production (VE/VCO2 ), 6 min walk distance (6MWD), and submaximal exercise duration (SED)]. We also studied the relationship between RV-PA coupling (TAPSE/PASP ratio) and echocardiographic parameters in patients with both data available. Univariate and multivariate linear regression models were used. Patients enrolled in EARTH (overall population) were mostly male (73.2%), mean age 61.0 ± 9.8 years, New York Heart Association class II-III (87.8%), mean LVEF of 26.6 ± 7.7%, and reduced peak VO2 (15.1 ± 4.6 mL/kg/min). Of these, 100 had both TAPSE and PASP available (TAPSE/PASP population): they exhibited higher BNP, wider QRS duration, larger LVEDVi, with more having tricuspid regurgitation compared with the 105 patients for whom these values were not available (all P < 0.05). RV-FAC (β = 7.5), LAVi (β = -0.1), and sex (female, β = -1.9) predicted peak VO2 in the overall population (all P = 0.01). When available, TAPSE/PASP ratio was the only echocardiographic parameter associated with peak VO2 (β = 6.8; P < 0.01), a threshold ≤0.45 predicting a peak VO2 ≤ 14 mL/kg/min (0.39 for VO2 ≤ 12). RV-MPI was the only echocardiographic parameter associated with ventilatory inefficiency (VE/VCO2 ) and 6MWD (β = 21.9 and β = -69.3, respectively, both P ≤ 0.01) in the overall population. In presence of TAPSE/PASP, it became an important predictor for those two CPET (β = -18.0 and β = 72.4, respectively, both P < 0.01), together with RV-MPI (β = 18.5, P < 0.01) for VE/VCO2 . Tricuspid regurgitation predicted SED (β = -3.2, P = 0.03).Right ventricular function assessed by echocardiography (RV-MPI and RV-FAC) is closely associated with exercise tolerance in patients with HFrEF. When the TAPSE/PASP ratio is available, this marker of RV-PA coupling becomes the stronger echocardiographic predictor of exercise capacity in this population, highlighting its potential role as a screening tool to identify patients with reduced exercise capacity and potentially triage them to formal peak VO2 and/or evaluation for advanced HF therapies." @default.
- W4200194016 created "2021-12-31" @default.
- W4200194016 creator A5015045005 @default.
- W4200194016 creator A5019447425 @default.
- W4200194016 creator A5021650901 @default.
- W4200194016 creator A5029829293 @default.
- W4200194016 creator A5030053531 @default.
- W4200194016 creator A5038307687 @default.
- W4200194016 creator A5057467775 @default.
- W4200194016 creator A5066218815 @default.
- W4200194016 creator A5067625616 @default.
- W4200194016 creator A5078082347 @default.
- W4200194016 creator A5081094721 @default.
- W4200194016 creator A9999999999 @default.
- W4200194016 date "2021-12-24" @default.
- W4200194016 modified "2023-10-13" @default.
- W4200194016 title "Right ventricular function and its coupling to pulmonary circulation predicts exercise tolerance in systolic heart failure" @default.
- W4200194016 cites W1997238737 @default.
- W4200194016 cites W1997811042 @default.
- W4200194016 cites W1998314270 @default.
- W4200194016 cites W2017780955 @default.
- W4200194016 cites W2019683378 @default.
- W4200194016 cites W2028320772 @default.
- W4200194016 cites W2034226929 @default.
- W4200194016 cites W2053715742 @default.
- W4200194016 cites W2056736967 @default.
- W4200194016 cites W2057790401 @default.
- W4200194016 cites W2071250626 @default.
- W4200194016 cites W2079265896 @default.
- W4200194016 cites W2084160023 @default.
- W4200194016 cites W2086266356 @default.
- W4200194016 cites W2092459172 @default.
- W4200194016 cites W2092579552 @default.
- W4200194016 cites W2124624517 @default.
- W4200194016 cites W2138559709 @default.
- W4200194016 cites W2151693299 @default.
- W4200194016 cites W2154473109 @default.
- W4200194016 cites W2170804276 @default.
- W4200194016 cites W2187630416 @default.
- W4200194016 cites W2224893286 @default.
- W4200194016 cites W2279897032 @default.
- W4200194016 cites W2471327176 @default.
- W4200194016 cites W2554277983 @default.
- W4200194016 cites W2607368991 @default.
- W4200194016 cites W2736919826 @default.
- W4200194016 cites W2740356580 @default.
- W4200194016 cites W2801226226 @default.
- W4200194016 cites W2824564930 @default.
- W4200194016 cites W2890408977 @default.
- W4200194016 cites W2890715574 @default.
- W4200194016 cites W2898329641 @default.
- W4200194016 cites W2915910487 @default.
- W4200194016 cites W2943775907 @default.
- W4200194016 cites W2945429853 @default.
- W4200194016 cites W3005615375 @default.
- W4200194016 cites W3022192186 @default.
- W4200194016 cites W4200194016 @default.
- W4200194016 doi "https://doi.org/10.1002/ehf2.13726" @default.
- W4200194016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34953062" @default.
- W4200194016 hasPublicationYear "2021" @default.
- W4200194016 type Work @default.
- W4200194016 citedByCount "12" @default.
- W4200194016 countsByYear W42001940162021 @default.
- W4200194016 countsByYear W42001940162022 @default.
- W4200194016 countsByYear W42001940162023 @default.
- W4200194016 crossrefType "journal-article" @default.
- W4200194016 hasAuthorship W4200194016A5015045005 @default.
- W4200194016 hasAuthorship W4200194016A5019447425 @default.
- W4200194016 hasAuthorship W4200194016A5021650901 @default.
- W4200194016 hasAuthorship W4200194016A5029829293 @default.
- W4200194016 hasAuthorship W4200194016A5030053531 @default.
- W4200194016 hasAuthorship W4200194016A5038307687 @default.
- W4200194016 hasAuthorship W4200194016A5057467775 @default.
- W4200194016 hasAuthorship W4200194016A5066218815 @default.
- W4200194016 hasAuthorship W4200194016A5067625616 @default.
- W4200194016 hasAuthorship W4200194016A5078082347 @default.
- W4200194016 hasAuthorship W4200194016A5081094721 @default.
- W4200194016 hasAuthorship W4200194016A9999999999 @default.
- W4200194016 hasBestOaLocation W42001940161 @default.
- W4200194016 hasConcept C126322002 @default.
- W4200194016 hasConcept C164705383 @default.
- W4200194016 hasConcept C2778198053 @default.
- W4200194016 hasConcept C2778921608 @default.
- W4200194016 hasConcept C2780940725 @default.
- W4200194016 hasConcept C2908647359 @default.
- W4200194016 hasConcept C71924100 @default.
- W4200194016 hasConcept C78085059 @default.
- W4200194016 hasConcept C99454951 @default.
- W4200194016 hasConceptScore W4200194016C126322002 @default.
- W4200194016 hasConceptScore W4200194016C164705383 @default.
- W4200194016 hasConceptScore W4200194016C2778198053 @default.
- W4200194016 hasConceptScore W4200194016C2778921608 @default.
- W4200194016 hasConceptScore W4200194016C2780940725 @default.
- W4200194016 hasConceptScore W4200194016C2908647359 @default.
- W4200194016 hasConceptScore W4200194016C71924100 @default.
- W4200194016 hasConceptScore W4200194016C78085059 @default.
- W4200194016 hasConceptScore W4200194016C99454951 @default.
- W4200194016 hasIssue "1" @default.